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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of natural killer cell mediated cytotoxicity
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Accession:GO:0045953 term browser browse the term
Definition:Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
Synonyms:exact_synonym: down regulation of natural killer cell mediated cytotoxicity;   downregulation of natural killer cell mediated cytotoxicity;   negative regulation of NK cell mediated cell death;   negative regulation of NK cell mediated cell killing;   negative regulation of NK cell mediated cytotoxicity;   negative regulation of natural killer cell mediated cell death;   negative regulation of natural killer cell mediated cell killing
 narrow_synonym: inhibition of natural killer cell mediated cytotoxicity
 related_synonym: negative regulation of NK cell mediated cytolysis;   negative regulation of natural killer cell mediated cytolysis


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negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Clec12b C-type lectin domain family 12, member B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:129,352,476...129,404,597
Ensembl chr 6:129,352,478...129,362,837 		JBrowse link
G Crk v-crk avian sarcoma virus CT10 oncogene homolog involved_in ISO RGD
MGI		 PMID:18835194 GO_REF:0000096 MGI:4417868 RGD:11568650 NCBI chr11:75,570,020...75,599,254
Ensembl chr11:75,570,085...75,597,734 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration involved_in ISO RGD
MGI		 PMID:9021955 GO_REF:0000096 MGI:4417868 RGD:9685777 NCBI chr17:24,912,164...24,915,065
Ensembl chr17:24,912,161...24,915,503 		JBrowse link
G Gm7030 predicted gene 7030 involved_in ISO (PMID:24018270) UniProt PMID:24018270 NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317 		JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 involved_in ISO (PMID:12874224)
(PMID:10190900)		 UniProt PMID:10190900 PMID:12874224 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 involved_in ISO (PMID:10799855), (PMID:17179229), (PMID:23335510), (PMID:9486650) UniProt PMID:9486650 PMID:10799855 PMID:17179229 PMID:23335510 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G Igf2 insulin-like growth factor 2 involved_in ISO RGD
MGI		 PMID:9021955 GO_REF:0000096 MGI:4417868 RGD:9685777 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Klrb1b killer cell lectin-like receptor subfamily B member 1B acts_upstream_of_or_within IGI
IDA		 (PMID:19535641)
(PMID:10229823), (PMID:10229828), (PMID:12858173), (PMID:14990792)		 MGI PMID:10229823 PMID:10229828 PMID:12858173 PMID:14990792 PMID:19535641 NCBI chr 6:128,790,669...128,803,278
Ensembl chr 6:128,790,669...128,803,294 		JBrowse link
G Klrc1 killer cell lectin-like receptor subfamily C, member 1 involved_in ISO (PMID:9485206), (PMID:9486650) UniProt PMID:9485206 PMID:9486650 NCBI chr 6:129,642,978...129,659,815
Ensembl chr 6:129,642,978...129,655,936 		JBrowse link
G Klrd1 killer cell lectin-like receptor, subfamily D, member 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:129,565,055...129,575,738
Ensembl chr 6:129,568,745...129,575,738 		JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772 		JBrowse link
G Sh2d1b1 SH2 domain containing 1B1 acts_upstream_of_or_within IMP (PMID:16127454) MGI PMID:16127454 NCBI chr 1:170,104,887...170,114,338
Ensembl chr 1:170,104,889...170,114,338 		JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 acts_upstream_of_or_within IMP (PMID:16127454) MGI PMID:16127454 NCBI chr 1:170,060,440...170,079,156
Ensembl chr 1:170,060,318...170,081,177 		JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gm7030 predicted gene 7030 involved_in ISO (PMID:24018270) UniProt PMID:24018270 NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317 		JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 involved_in IMP (MGI:5491117|PMID:23408620) UniProt PMID:23408620 MGI:5491117 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772 		JBrowse link
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in IMP (MGI:5512785|PMID:23696226) UniProt PMID:23696226 MGI:5512785 NCBI chr 7:25,161,127...25,177,072
Ensembl chr 7:25,161,132...25,177,028 		JBrowse link
G Clec2m C-type lectin domain family 2, member m ISO RGD PMID:12782717 RGD:1299590 NCBI chr 6:129,299,128...129,308,770
Ensembl chr 6:129,299,127...129,308,759 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in IMP (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Klre1 killer cell lectin-like receptor family E member 1 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 6:129,536,329...129,562,790
Ensembl chr 6:129,554,868...129,562,790 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec2d C-type lectin domain family 2, member d acts_upstream_of_or_within IDA
IGI		 (PMID:12858173), (PMID:14990792)
(PMID:19535641)		 MGI PMID:12858173 PMID:14990792 PMID:19535641 NCBI chr 6:129,157,578...129,163,498
Ensembl chr 6:129,157,578...129,163,497 		JBrowse link
G H2-Bl histocompatibility 2, blastocyst acts_upstream_of_or_within IDA (PMID:12902470) MGI PMID:12902470 NCBI chr17:36,391,002...36,395,141
Ensembl chr17:36,391,007...36,395,115 		JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 involved_in ISO (PMID:18502829), (PMID:2784569), (PMID:8046333) UniProt PMID:2784569 PMID:8046333 PMID:18502829 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443 		JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 involved_in ISO (PMID:11290782) UniProt PMID:11290782 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 NOT|involved_in ISO (PMID:18502829)
(PMID:18502829), (PMID:8839770)		 UniProt PMID:8839770 PMID:18502829 NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 involved_in ISO (PMID:25631937), (PMID:9754572) UniProt PMID:9754572 PMID:25631937 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A involved_in ISO (PMID:21857942) UniProt PMID:21857942 NCBI chr 1:106,973,317...106,980,033
Ensembl chr 1:106,973,317...106,980,033 		JBrowse link
G Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:33,181,044...33,201,938
Ensembl chr13:33,187,233...33,201,940 		JBrowse link
G Serpinb9b serine (or cysteine) peptidase inhibitor, clade B, member 9b involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:33,211,397...33,224,571
Ensembl chr13:33,211,399...33,225,867 		JBrowse link
G Serpinb9c serine (or cysteine) peptidase inhibitor, clade B, member 9c involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:33,333,258...33,343,737
Ensembl chr13:33,333,258...33,343,725 		JBrowse link
G Serpinb9d serine (or cysteine) peptidase inhibitor, clade B, member 9d involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:33,376,938...33,387,964
Ensembl chr13:33,376,942...33,387,112 		JBrowse link
G Serpinb9e serine (or cysteine) peptidase inhibitor, clade B, member 9e involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:33,433,591...33,444,833
Ensembl chr13:33,433,595...33,444,833 		JBrowse link
G Serpinb9f serine (or cysteine) peptidase inhibitor, clade B, member 9f involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:33,508,060...33,519,353
Ensembl chr13:33,508,060...33,519,353 		JBrowse link
G Serpinb9g serine (or cysteine) peptidase inhibitor, clade B, member 9g involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:33,668,773...33,679,985
Ensembl chr13:33,668,773...33,679,987 		JBrowse link
G Serpinb9h serine (or cysteine) peptidase inhibitor, clade B, member 9h involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:33,579,656...33,589,128
Ensembl chr13:33,579,744...33,589,268 		JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) involved_in ISO RGD
MGI		 PMID:8120379 GO_REF:0000096 MGI:4417868 RGD:2312378 NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199 		JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) involved_in ISO RGD
MGI		 PMID:8120379 GO_REF:0000096 MGI:4417868 RGD:2312378 NCBI chr17:34,423,453...34,435,295
Ensembl chr17:34,422,501...34,435,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28577
    cellular process 17497
      negative regulation of cellular process 5530
        negative regulation of cell killing 48
          negative regulation of leukocyte mediated cytotoxicity 40
            negative regulation of natural killer cell mediated cytotoxicity 34
              negative regulation of natural killer cell degranulation 2
              negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 5
              protection from natural killer cell mediated cytotoxicity 17
Path 2
Term Annotations click to browse term
  biological_process 28577
    response to stimulus 10767
      response to external stimulus 2932
        response to external biotic stimulus 2016
          response to other organism 2013
            defense response to other organism 1411
              defense response to symbiont 1281
                innate immune response 1079
                  natural killer cell mediated immunity 100
                    regulation of natural killer cell mediated immunity 74
                      negative regulation of natural killer cell mediated immunity 35
                        negative regulation of natural killer cell mediated cytotoxicity 34
                          negative regulation of natural killer cell degranulation 2
                          negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 5
                          protection from natural killer cell mediated cytotoxicity 17
paths to the root