negative regulation of CD8-positive, alpha-beta T cell differentiation - Ontology Report

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Term:	negative regulation of CD8-positive, alpha-beta T cell differentiation	go back to main search page
Accession:	GO:0043377	browse the term
Definition:	Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.
Comment:	Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:	exact_synonym:	down regulation of CD8-positive, alpha-beta T cell differentiation; downregulation of CD8-positive, alpha-beta T cell differentiation; negative regulation of CD8-positive T lymphocyte differentiation; negative regulation of CD8-positive T-cell differentiation; negative regulation of CD8-positive, alpha beta T lymphocyte differentiation
	narrow_synonym:	inhibition of CD8-positive, alpha-beta T cell differentiation
	related_synonym:	negative regulation of CD8-positive, alpha-beta T cell development

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Rat (3) Mouse (3) Human (3) Chinchilla (3) Bonobo (3) Dog (3) Squirrel (3) Pig (3) Green Monkey (3) Naked Mole-rat (3) All
Genes (3)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Slc4a2

solute carrier family 4 member 2

involved_in

GO_REF:0000024
(MGI:6840447|PMID:24515893)

GO_REF:0000024 MGI:6840447

NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965

suppressor of cytokine signaling 1

involved_in

GO_REF:0000107
GO_REF:0000024
(MGI:6140589|PMID:24880459)

GO_REF:0000024 GO_REF:0000107 MGI:6140589

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

zinc finger and BTB domain containing 7B

involved_in

(MGI:5446998|PMID:22730529), (MGI:6140589|PMID:24880459)

NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236

Term paths to the root

Path 1
Term	Annotations
biological_process	19692
immune system process	2822
leukocyte activation	1032
lymphocyte activation	837
T cell activation	591
alpha-beta T cell activation	200
CD8-positive, alpha-beta T cell activation	35
CD8-positive, alpha-beta T cell differentiation	20
negative regulation of CD8-positive, alpha-beta T cell differentiation	3
Path 2
Term	Annotations
biological_process	19692
cellular process	18168
cellular developmental process	4695
cell differentiation	4694
cell development	3269
hemopoiesis	1061
leukocyte differentiation	674
mononuclear cell differentiation	544
lymphocyte differentiation	447
T cell differentiation	324
alpha-beta T cell differentiation	141
CD8-positive, alpha-beta T cell differentiation	20
regulation of CD8-positive, alpha-beta T cell differentiation	8
negative regulation of CD8-positive, alpha-beta T cell differentiation	3

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