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ONTOLOGY REPORT - ANNOTATIONS

Term:cAMP-mediated signaling
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Accession:GO:0019933 term browser browse the term
Definition:An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell.
Synonyms:exact_synonym: 3',5' cAMP-mediated signaling;   3',5' cAMP-mediated signalling;   adenosine 3',5'-cyclophosphate-mediated signaling;   adenosine 3',5'-cyclophosphate-mediated signalling;   cAMP signaling;   cAMP signalling;   cAMP-mediated signal transduction;   cAMP-mediated signalling;   cyclic AMP-mediated signaling;   cyclic AMP-mediated signalling


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cAMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY1 adenylate cyclase 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116 		JBrowse link
G ADCY2 adenylate cyclase 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 5:7,396,138...7,830,081
Ensembl chr 5:7,396,138...7,830,081 		JBrowse link
G ADCY8 adenylate cyclase 8 ISO RGD PMID:8163524 RGD:69741 NCBI chr 8:130,780,301...131,040,909
Ensembl chr 8:130,780,301...131,040,909 		JBrowse link
G ADCYAP1 adenylate cyclase activating polypeptide 1 involved_in IMP (PMID:23800469) UniProt PMID:23800469 NCBI chr18:904,411...912,172
Ensembl chr18:904,871...912,172 		JBrowse link
G ADCYAP1R1 ADCYAP receptor type I involved_in ISO
IEA		 RGD
Ensembl		 PMID:8396727 GO_REF:0000107 RGD:631732 NCBI chr 7:31,052,308...31,111,474
Ensembl chr 7:31,052,308...31,111,474 		JBrowse link
G ADGRG6 adhesion G protein-coupled receptor G6 involved_in ISS
IMP		 (PMID:24227709) UniProt PMID:24227709 GO_REF:0000024 NCBI chr 6:142,302,007...142,446,261
Ensembl chr 6:142,301,854...142,446,266 		JBrowse link
G ADM adrenomedullin involved_in ISO
IEA		 RGD
Ensembl		 PMID:12193565 GO_REF:0000107 RGD:628358 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397 		JBrowse link
G AHR aryl hydrocarbon receptor involved_in IDA (PMID:17329248) UniProt PMID:17329248 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G ATF1 activating transcription factor 1 involved_in IDA (PMID:25644539) MGI PMID:25644539 NCBI chr12:50,763,459...50,821,162
Ensembl chr12:50,763,710...50,821,162 		JBrowse link
G CAP1 cyclase associated actin cytoskeleton regulatory protein 1 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:40,040,240...40,072,648
Ensembl chr 1:40,040,233...40,072,649 		JBrowse link
G CAP2 cyclase associated actin cytoskeleton regulatory protein 2 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:17,393,595...17,557,780
Ensembl chr 6:17,393,595...17,557,780 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IEA
IDA		 (PMID:23258413), (PMID:24077100), (PMID:28738408), (PMID:30007416) Ensembl
UniProt		 PMID:23258413 PMID:24077100 PMID:28738408 PMID:30007416 GO_REF:0000107 NCBI chr 6:73,423,711...73,452,297
Ensembl chr 6:73,413,515...73,452,297 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 involved_in IDA (PMID:25644539) MGI PMID:25644539 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G DGKQ diacylglycerol kinase theta involved_in IDA (PMID:17664281) UniProt PMID:17664281 NCBI chr 4:958,887...973,569
Ensembl chr 4:958,887...986,895 		JBrowse link
G EPHA5 EPH receptor A5 involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:65,319,567...65,670,489
Ensembl chr 4:65,319,563...65,670,495 		JBrowse link
G GAL galanin and GMAP prepropeptide involved_in IDA (PMID:17982695) UniProt PMID:17982695 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:28258188 RGD:13792662 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374 		JBrowse link
G GHRHR growth hormone releasing hormone receptor ISO RGD PMID:10465288 RGD:1624951 NCBI chr 7:30,963,953...30,979,528
Ensembl chr 7:30,938,669...30,993,254 		JBrowse link
G GLP1R glucagon like peptide 1 receptor involved_in ISO
IDA		 (PMID:7589461) RGD
UniProt		 PMID:7589461 PMID:10446905 RGD:1598448 NCBI chr 6:39,048,781...39,091,303
Ensembl chr 6:39,048,781...39,091,303 		JBrowse link
G KSR1 kinase suppressor of ras 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:27,456,448...27,626,435
Ensembl chr17:27,456,448...27,626,438 		JBrowse link
G PDE10A phosphodiesterase 10A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117 		JBrowse link
G PDE11A phosphodiesterase 11A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:177,623,244...178,108,339
Ensembl chr 2:177,623,244...178,108,339 		JBrowse link
G PDE1A phosphodiesterase 1A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:182,140,041...182,716,797
Ensembl chr 2:182,139,968...182,523,359 		JBrowse link
G PDE1B phosphodiesterase 1B involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:54,549,601...54,579,239
Ensembl chr12:54,549,601...54,579,239 		JBrowse link
G PDE1C phosphodiesterase 1C involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:31,616,777...32,428,224
Ensembl chr 7:31,751,179...32,428,131 		JBrowse link
G PDE2A phosphodiesterase 2A involved_in IMP
IBA
IEA		 (PMID:17704206) UniProt
GO_Central
TreeGrafter		 PMID:17704206 GO_REF:0000033 GO_REF:0000118 NCBI chr11:72,576,141...72,674,422
Ensembl chr11:72,576,141...72,674,591 		JBrowse link
G PDE3A phosphodiesterase 3A involved_in IMP
IBA		 (PMID:17704206) UniProt
GO_Central		 PMID:17704206 GO_REF:0000033 NCBI chr12:20,368,537...20,688,583
Ensembl chr12:20,368,537...20,688,583 		JBrowse link
G PDE3B phosphodiesterase 3B involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:14,643,804...14,872,044
NCBI chr11:14,887,823...14,899,321
Ensembl chr11:14,643,804...14,872,044 		JBrowse link
G PDE4A phosphodiesterase 4A involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:10,416,773...10,469,631
Ensembl chr19:10,416,773...10,469,630 		JBrowse link
G PDE4B phosphodiesterase 4B involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579 		JBrowse link
G PDE4C phosphodiesterase 4C involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:18,207,965...18,255,362
Ensembl chr19:18,207,965...18,248,200
Ensembl chr19:18,207,965...18,248,200 		JBrowse link
G PDE4D phosphodiesterase 4D involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120 		JBrowse link
G PDE5A phosphodiesterase 5A involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804 		JBrowse link
G PDE6A phosphodiesterase 6A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:149,857,953...149,944,793
Ensembl chr 5:149,857,953...149,944,793 		JBrowse link
G PDE6B phosphodiesterase 6B involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:625,573...670,782
Ensembl chr 4:625,573...670,782 		JBrowse link
G PDE6C phosphodiesterase 6C involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:93,612,537...93,666,010
Ensembl chr10:93,612,537...93,666,010 		JBrowse link
G PDE7A phosphodiesterase 7A involved_in ISO
IDA
IEA
IBA		 (PMID:9195912) RGD
UniProt
Ensembl
GO_Central		 PMID:9195912 PMID:11304758 GO_REF:0000033 GO_REF:0000107 RGD:731232 NCBI chr 8:65,714,334...65,842,064
Ensembl chr 8:65,714,334...65,842,322 		JBrowse link
G PDE7B phosphodiesterase 7B involved_in IDA
IEA
IBA		 (PMID:10814504), (PMID:10872825) UniProt
TreeGrafter
GO_Central		 PMID:10814504 PMID:10872825 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:135,851,701...136,195,574
Ensembl chr 6:135,851,701...136,195,574 		JBrowse link
G PDE8A phosphodiesterase 8A involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:84,980,467...85,139,142
Ensembl chr15:84,980,440...85,139,145 		JBrowse link
G PDE8B phosphodiesterase 8B involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:77,086,715...77,428,256
Ensembl chr 5:77,210,449...77,428,256
Ensembl chr 5:77,210,449...77,428,256 		JBrowse link
G PDE9A phosphodiesterase 9A involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr21:42,653,621...42,775,509
Ensembl chr21:42,653,621...42,775,509 		JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 involved_in NAS
IDA		 (PMID:10934204)
(PMID:23800469)		 UniProt PMID:10934204 PMID:23800469 NCBI chr 4:159,103,079...159,360,173
Ensembl chr 4:159,103,013...159,360,174 		JBrowse link
G SOX9 SRY-box transcription factor 9 involved_in IDA
IEA		 (PMID:10805756) UniProt
Ensembl		 PMID:10805756 GO_REF:0000107 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416 		JBrowse link
G TGM2 transglutaminase 2 involved_in TAS (PMID:11013236) UniProt PMID:11013236 NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578 		JBrowse link
negative regulation of cAMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in IMP
IEA
IBA		 (PMID:25639753) UniProt
Ensembl
GO_Central		 PMID:25639753 GO_REF:0000033 GO_REF:0000107 NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,250 		JBrowse link
G CDC34 cell division cycle 34, ubiqiutin conjugating enzyme involved_in IDA (PMID:10373550) UniProt PMID:10373550 NCBI chr19:531,760...542,087
Ensembl chr19:531,760...542,092 		JBrowse link
G LPAR1 lysophosphatidic acid receptor 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:12139919 GO_REF:0000107 RGD:727395 NCBI chr 9:110,873,263...111,038,998
Ensembl chr 9:110,873,263...111,038,470 		JBrowse link
G MGRN1 mahogunin ring finger 1 involved_in IDA
IBA		 (PMID:19737927) UniProt
GO_Central		 PMID:19737927 GO_REF:0000033 NCBI chr16:4,624,826...4,690,972
Ensembl chr16:4,616,493...4,690,974 		JBrowse link
G NPY2R neuropeptide Y receptor Y2 ISO RGD PMID:11408607 RGD:633494 NCBI chr 4:155,173,723...155,217,076
Ensembl chr 4:155,208,636...155,217,078 		JBrowse link
G NUCB2 nucleobindin 2 ISO RGD PMID:22486620 RGD:9831186 NCBI chr11:17,276,739...17,349,980
Ensembl chr11:17,208,153...17,349,980 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:16019191 GO_REF:0000107 RGD:9835005 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643 		JBrowse link
G OPRM1 opioid receptor mu 1 involved_in IDA (PMID:20525224) UniProt PMID:20525224 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PDE10A phosphodiesterase 10A ISO RGD PMID:10583409 RGD:68285 NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117 		JBrowse link
G PDE11A phosphodiesterase 11A involved_in ISO
IBA
IEA		 RGD
GO_Central
TreeGrafter		 PMID:11502204 GO_REF:0000033 GO_REF:0000118 RGD:633590 NCBI chr 2:177,623,244...178,108,339
Ensembl chr 2:177,623,244...178,108,339 		JBrowse link
G PDE2A phosphodiesterase 2A involved_in ISO
IBA
IEA		 RGD
GO_Central
TreeGrafter		 PMID:12107056 GO_REF:0000033 GO_REF:0000118 RGD:625635 NCBI chr11:72,576,141...72,674,422
Ensembl chr11:72,576,141...72,674,591 		JBrowse link
G PDE3A phosphodiesterase 3A involved_in ISO
IEA		 RGD
Ensembl		 PMID:9884079 GO_REF:0000107 RGD:2312525 NCBI chr12:20,368,537...20,688,583
Ensembl chr12:20,368,537...20,688,583 		JBrowse link
G PDE3B phosphodiesterase 3B ISO RGD PMID:9884079 RGD:2312525 NCBI chr11:14,643,804...14,872,044
NCBI chr11:14,887,823...14,899,321
Ensembl chr11:14,643,804...14,872,044 		JBrowse link
G PDE4D phosphodiesterase 4D involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120 		JBrowse link
G UBE2B ubiquitin conjugating enzyme E2 B involved_in IDA (PMID:10373550) UniProt PMID:10373550 NCBI chr 5:134,371,569...134,392,108
Ensembl chr 5:134,371,184...134,392,108 		JBrowse link
positive regulation of cAMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 ISO RGD PMID:17901570 RGD:2325275 NCBI chr18:904,411...912,172
Ensembl chr18:904,871...912,172 		JBrowse link
G ADCYAP1R1 ADCYAP receptor type I involved_in ISO
IEA		 hop2 splice variant RGD
Ensembl		 PMID:16905223 GO_REF:0000107 RGD:2315974 NCBI chr 7:31,052,308...31,111,474
Ensembl chr 7:31,052,308...31,111,474 		JBrowse link
G ADORA2B adenosine A2b receptor ISO RGD PMID:8012696 PMID:11882603 RGD:2316150 RGD:631750 NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746 		JBrowse link
G CHGA chromogranin A ISO RGD PMID:22459152 RGD:6906968 NCBI chr14:92,922,664...92,935,285
Ensembl chr14:92,923,150...92,935,285 		JBrowse link
G CRH corticotropin releasing hormone involved_in ISO
IEA		 RGD
Ensembl		 PMID:7477349 GO_REF:0000107 RGD:70047 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO RGD PMID:20682782 RGD:5491010 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:16005543 PMID:20682782 PMID:21277852 RGD:5131269 RGD:5491003 RGD:5491010 NCBI chr 7:30,651,942...30,700,103
Ensembl chr 7:30,651,942...30,700,129 		JBrowse link
G ECE1 endothelin converting enzyme 1 ISO RGD PMID:22881710 RGD:7243859 NCBI chr 1:21,217,250...21,345,504
Ensembl chr 1:21,217,247...21,345,572 		JBrowse link
G GHRH growth hormone releasing hormone ISO RGD PMID:10579333 RGD:1624957 NCBI chr20:37,251,086...37,261,814
Ensembl chr20:37,251,086...37,261,819 		JBrowse link
G GIP gastric inhibitory polypeptide involved_in ISO
IEA		 RGD
Ensembl		 PMID:8958204 GO_REF:0000107 RGD:2312537 NCBI chr17:48,958,554...48,968,596
Ensembl chr17:48,958,554...48,968,596 		JBrowse link
G GIPR gastric inhibitory polypeptide receptor involved_in ISO
IEA		 RGD
Ensembl		 PMID:11014226 GO_REF:0000107 RGD:2312607 NCBI chr19:45,668,221...45,683,722
Ensembl chr19:45,668,221...45,683,722 		JBrowse link
G GPR3 G protein-coupled receptor 3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:12220620 GO_REF:0000107 RGD:632931 NCBI chr 1:27,392,622...27,395,814
Ensembl chr 1:27,392,622...27,395,814 		JBrowse link
G INSL3 insulin like 3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:12114498 GO_REF:0000107 RGD:633070 NCBI chr19:17,816,512...17,821,519
Ensembl chr19:17,816,512...17,821,574 		JBrowse link
G OPRM1 opioid receptor mu 1 involved_in IDA (PMID:20214800) UniProt PMID:20214800 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PEBP1 phosphatidylethanolamine binding protein 1 ISO RGD PMID:14654844 RGD:2302817 NCBI chr12:118,136,124...118,145,584
Ensembl chr12:118,136,124...118,145,584 		JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:11278900 RGD:10003101 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,816 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:11278900 RGD:10003101 NCBI chr 5:40,679,915...40,746,800
Ensembl chr 5:40,679,915...40,693,735 		JBrowse link
G RXFP2 relaxin family peptide receptor 2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15956681 GO_REF:0000107 RGD:1600172 NCBI chr13:31,739,526...31,803,389
Ensembl chr13:31,739,526...31,803,389 		JBrowse link
G SCT secretin involved_in ISO
IEA		 RGD
Ensembl		 PMID:12403838 GO_REF:0000107 RGD:9590237 NCBI chr11:626,309...627,181
Ensembl chr11:626,309...627,181 		JBrowse link
G SCTR secretin receptor ISO RGD PMID:12403838 RGD:9590237 NCBI chr 2:119,439,843...119,524,483
Ensembl chr 2:119,439,843...119,525,301 		JBrowse link
G TAAR1 trace amine associated receptor 1 ISO RGD PMID:26372541 RGD:11531774 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,643,312...132,659,182 		JBrowse link
G TOR2A torsin family 2 member A involved_in IDA (PMID:12910263) UniProt PMID:12910263 NCBI chr 9:127,731,524...127,735,294
Ensembl chr 9:127,731,524...127,735,313 		JBrowse link
G UCN urocortin involved_in ISO
IEA		 RGD
Ensembl		 PMID:7477349 GO_REF:0000107 RGD:70047 NCBI chr 2:27,307,400...27,308,445
Ensembl chr 2:27,307,400...27,308,445 		JBrowse link
regulation of cAMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAI1 G protein subunit alpha i1 involved_in ISS UniProt GO_REF:0000024 NCBI chr 7:80,134,831...80,226,181
Ensembl chr 7:79,768,028...80,226,181 		JBrowse link
G PDE2A phosphodiesterase 2A involved_in IMP (PMID:15938621) UniProt PMID:15938621 NCBI chr11:72,576,141...72,674,422
Ensembl chr11:72,576,141...72,674,591 		JBrowse link
G PDE4D phosphodiesterase 4D ISO RGD PMID:18073242 RGD:2312596 NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120 		JBrowse link
G PEX5L peroxisomal biogenesis factor 5 like involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:179,794,958...180,036,937
Ensembl chr 3:179,794,958...180,037,053 		JBrowse link
G RASD2 RASD family member 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr22:35,532,806...35,553,999
Ensembl chr22:35,540,831...35,553,999 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19613
    cellular process 18233
      signal transduction 6566
        intracellular signal transduction 2993
          intracellular signaling cassette 2123
            cAMP-mediated signaling 76
              negative regulation of cAMP-mediated signaling 15
              positive regulation of cAMP-mediated signaling 23
              regulation of cAMP-mediated signaling + 40
Path 2
Term Annotations click to browse term
  biological_process 19613
    biological regulation 13363
      regulation of biological process 12979
        signaling 7170
          signal transduction 6566
            intracellular signal transduction 2993
              intracellular signaling cassette 2123
                cAMP-mediated signaling 76
                  negative regulation of cAMP-mediated signaling 15
                  positive regulation of cAMP-mediated signaling 23
                  regulation of cAMP-mediated signaling + 40
paths to the root