RGD Reference Report - Characterization of the rat INSL3 receptor. - Rat Genome Database

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Characterization of the rat INSL3 receptor.

Authors: Scott, DJ  Fu, P  Shen, PJ  Gundlach, A  Layfield, S  Riesewijk, A  Tomiyama, H  Hutson, JM  Tregear, GW  Bathgate, RA 
Citation: Scott DJ, etal., Ann N Y Acad Sci. 2005 May;1041:13-6.
RGD ID: 1600172
Pubmed: PMID:15956681   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1282.003   (Journal Full-text)

Human LGR8, initially discovered as a low-affinity relaxin receptor, has now been characterized as the INSL3 receptor. To investigate LGR8 function in the rat, an LGR8 ortholog was identified in the rat genome, and the full-length sequence was cloned and expressed. Rat LGR8 bound INSL3 with high affinity, clearly demonstrating that it is the rat INSL3 receptor. Interestingly, native rat relaxin did not activate rat LGR8, indicating that relaxin is not an endogenous ligand for rat LGR8. LGR8 mRNA expression was demonstrated in the gubernaculum at the time of testis descent and in the testis associated with germ cells.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of cAMP-mediated signaling  IDA 1600172 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
peptide hormone binding  IPIINSL3 (Homo sapiens)1600172 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rxfp2  (relaxin family peptide receptor 2)


Additional Information