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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellularly glycine-gated chloride channel activity
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Accession:GO:0016934 term browser browse the term
Definition:Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Synonyms:exact_synonym: extracellular-glycine-gated chloride channel activity
 broad_synonym: glycine receptor
 related_synonym: glycine-inhibited chloride channel activity
 alt_id: GO:0004891
 xref: reactome:R-HSA-975389 "GLRA:GLRB:Gly transports extracellular Cl- to cytosol"

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extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glra1 glycine receptor alpha 1 enables ISO (PMID:16144831), (PMID:2155780), (PMID:8137830)
(MGI:5707576|PMID:24801766)
(PMID:7920629)
(PMID:8062927)
(PMID:16672662)		 RGD
UniProt
MGI		 PMID:2155780 PMID:7920629 PMID:8062927 PMID:8137830 PMID:12223345 More... MGI:5707576 RGD:625689 NCBI chrNW_004955408:6,236,092...6,333,166
Ensembl chrNW_004955408:6,236,092...6,333,166 		JBrowse link
G Glra2 glycine receptor alpha 2 enables ISO (PMID:2155780) UniProt PMID:2155780 NCBI chrNW_004955519:3,492,313...3,682,028
Ensembl chrNW_004955519:3,492,305...3,682,087 		JBrowse link
G Glra3 glycine receptor alpha 3 enables ISO PMID:23895467
(PMID:26416729)		 RGD
UniProt		 PMID:2176214 PMID:23895467 PMID:26416729 RGD:11035333 RGD:728440 NCBI chrNW_004955403:32,304,178...32,445,135
Ensembl chrNW_004955403:32,304,178...32,445,135 		JBrowse link
G Glra4 glycine receptor alpha 4 enables ISO (MGI:5751681|PMID:10762330) UniProt PMID:10762330 MGI:5751681 NCBI chrNW_004955548:712,257...736,279
Ensembl chrNW_004955548:712,257...736,327 		JBrowse link
G Glrb glycine receptor beta contributes_to
enables		 ISO (PMID:8717357)
(PMID:12809985), (PMID:16672662)		 UniProtKB
MGI		 PMID:8717357 PMID:12809985 PMID:16672662 NCBI chrNW_004955471:10,153,197...10,238,052
Ensembl chrNW_004955471:10,152,156...10,238,832 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14225
    transporter activity 869
      transmembrane transporter activity 794
        monoatomic ion transmembrane transporter activity 555
          monoatomic anion transmembrane transporter activity 117
            monoatomic anion channel activity 79
              chloride channel activity 66
                extracellularly glycine-gated chloride channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 14225
    transporter activity 869
      transmembrane transporter activity 794
        passive transmembrane transporter activity 391
          channel activity 391
            gated channel activity 253
              ligand-gated channel activity 158
                ligand-gated monoatomic ion channel activity 154
                  extracellular ligand-gated monoatomic ion channel activity 64
                    excitatory extracellular ligand-gated monoatomic ion channel activity 35
                      extracellularly glycine-gated ion channel activity 5
                        extracellularly glycine-gated chloride channel activity 5
paths to the root