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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellularly glycine-gated chloride channel activity
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Accession:GO:0016934 term browser browse the term
Definition:Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Synonyms:exact_synonym: extracellular-glycine-gated chloride channel activity
 broad_synonym: glycine receptor
 related_synonym: glycine-inhibited chloride channel activity
 alt_id: GO:0004891
 xref: reactome:R-HSA-975389 "GLRA:GLRB:Gly transports extracellular Cl- to cytosol"


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extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLRA1 glycine receptor alpha 1 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:12223345 GO_REF:0000002 GO_REF:0000107 RGD:625689 NCBI chr 5:147,245,741...147,348,555
Ensembl chr 5:153,248,488...153,350,567 		JBrowse link
G GLRA2 glycine receptor alpha 2 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr  X:7,145,794...7,349,911
Ensembl chr  X:14,430,441...14,634,973 		JBrowse link
G GLRA3 glycine receptor alpha 3 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:2176214 GO_REF:0000002 GO_REF:0000107 RGD:728440 NCBI chr 4:166,865,061...167,045,844
Ensembl chr 4:179,083,211...179,279,232 		JBrowse link
G GLRA4 glycine receptor alpha 4 enables IEA Ensembl GO_REF:0000107 NCBI chr  X:92,933,694...92,957,714
Ensembl chr  X:103,317,486...103,338,910 		JBrowse link
G GLRB glycine receptor beta contributes_to
enables		 ISO
IEA		 (PMID:8717357) UniProtKB
TreeGrafter
Ensembl
InterPro		 PMID:8717357 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:149,422,654...149,518,669
Ensembl chr 4:161,236,610...161,333,035 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17494
    transporter activity 1158
      transmembrane transporter activity 1070
        monoatomic ion transmembrane transporter activity 716
          monoatomic anion transmembrane transporter activity 143
            monoatomic anion channel activity 93
              chloride channel activity 78
                extracellularly glycine-gated chloride channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 17494
    transporter activity 1158
      transmembrane transporter activity 1070
        passive transmembrane transporter activity 497
          channel activity 497
            gated channel activity 320
              ligand-gated channel activity 189
                ligand-gated monoatomic ion channel activity 185
                  extracellular ligand-gated monoatomic ion channel activity 74
                    excitatory extracellular ligand-gated monoatomic ion channel activity 42
                      extracellularly glycine-gated ion channel activity 5
                        extracellularly glycine-gated chloride channel activity 5
paths to the root