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ONTOLOGY REPORT - ANNOTATIONS

Term:damaged DNA binding
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Accession:GO:0003684 term browser browse the term
Definition:Binding to damaged DNA.
Synonyms:related_synonym: DNA repair enzyme;   DNA repair protein

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damaged DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO (PMID:12524539), (PMID:14706345), (PMID:24703901) BHF-UCL PMID:12524539 PMID:14706345 PMID:24703901 NCBI chr29:20,978,878...20,981,393 JBrowse link
G APTX aprataxin enables IEA Ensembl GO_REF:0000107 NCBI chr12:47,239,094...47,346,528
Ensembl chr12:47,258,798...47,287,102 		JBrowse link
G AUNIP aurora kinase A and ninein interacting protein enables ISO (PMID:29042561) UniProt PMID:29042561 NCBI chr20:106,912,338...106,936,183
Ensembl chr20:106,912,431...106,939,583 		JBrowse link
G BRCA1 BRCA1 DNA repair associated enables ISO (PMID:11934988) MGI PMID:11934988 NCBI chr16:63,162,827...63,243,928 JBrowse link
G BRME1 break repair meiotic recombinase recruitment factor 1 enables ISO (PMID:32345962), (PMID:32460033), (PMID:32463460) MGI PMID:32345962 PMID:32460033 PMID:32463460 NCBI chr 6:12,543,242...12,567,863
Ensembl chr 6:12,543,141...12,556,423 		JBrowse link
G CREBBP CREB binding protein enables ISO (PMID:24939902) UniProt PMID:24939902 NCBI chr 5:3,415,548...3,570,030
Ensembl chr 5:3,415,412...3,540,943 		JBrowse link
G CRY2 cryptochrome circadian regulator 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:19,459,734...19,498,807
Ensembl chr 1:19,472,231...19,498,790 		JBrowse link
G CUL4B cullin 4B contributes_to ISO (PMID:22334663) UniProt PMID:22334663
G DCLRE1A DNA cross-link repair 1A enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:106,713,857...106,735,268
Ensembl chr 9:106,713,895...106,731,999 		JBrowse link
G DCLRE1B DNA cross-link repair 1B enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:19,750,106...19,757,190
Ensembl chr20:19,748,898...19,756,901 		JBrowse link
G DCLRE1C DNA cross-link repair 1C enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:14,929,221...14,974,791
Ensembl chr 9:14,929,317...14,965,443 		JBrowse link
G DDB1 damage specific DNA binding protein 1 enables
contributes_to		 ISO
IEA		 (PMID:22334663) RGD
Ensembl
UniProt		 PMID:12145536 PMID:22334663 GO_REF:0000107 RGD:632554 NCBI chr 1:12,508,712...12,543,127
Ensembl chr 1:12,508,443...12,544,913 		JBrowse link
G DDB2 damage specific DNA binding protein 2 contributes_to
enables		 ISO
IEA		 (PMID:22334663) UniProt
TreeGrafter
InterPro
Ensembl		 PMID:22334663 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:18,071,011...18,096,660
Ensembl chr 1:18,071,383...18,096,595 		JBrowse link
G EP300 E1A binding protein p300 enables IEA Ensembl GO_REF:0000107 NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:38,857,067...38,900,177
Ensembl chr 6:38,854,803...38,872,967 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit enables IEA TreeGrafter GO_REF:0000118 NCBI chr 6:38,804,296...38,823,229
Ensembl chr 6:38,801,423...38,823,073 		JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit enables IEA TreeGrafter GO_REF:0000118 NCBI chr 5:13,378,282...13,410,307
Ensembl chr 5:13,378,401...13,406,541 		JBrowse link
G ERCC5 ERCC excision repair 5, endonuclease enables ISO (PMID:32821917) UniProt PMID:32821917 NCBI chr 3:81,406,103...81,441,422
Ensembl chr 3:81,405,872...81,436,040 		JBrowse link
G H2AFX histone H2AX enables ISO (PMID:11934988) MGI PMID:11934988 NCBI chr 1:110,466,692...110,468,776
Ensembl chr 1:110,467,775...110,468,206 		JBrowse link
G HMGB1 high mobility group box 1 enables ISO (PMID:17803946) UniProt PMID:17803946 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G HMGB2 high mobility group box 2 enables ISO (PMID:8226934) UniProt PMID:8226934 NCBI chr 7:119,440,089...119,442,806
Ensembl chr 7:119,440,468...119,443,578 		JBrowse link
G LOC103248265 lysine-specific demethylase 4D enables ISO (PMID:24550317) MGI PMID:24550317 NCBI chr 1:86,190,515...86,215,061
Ensembl chr 1:86,212,761...86,214,490 		JBrowse link
G MSH2 mutS homolog 2 enables IEA Ensembl GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819 		JBrowse link
G MSH3 mutS homolog 3 enables ISO (PMID:10545954) MGI PMID:10545954 NCBI chr 4:74,811,181...75,032,067
Ensembl chr 4:74,811,198...75,032,005 		JBrowse link
G MSH6 mutS homolog 6 enables IEA Ensembl GO_REF:0000107 NCBI chr14:59,375,602...59,400,252
Ensembl chr14:59,375,691...59,400,174 		JBrowse link
G NBN nibrin enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:85,017,807...85,069,219
Ensembl chr 8:85,015,752...85,069,028 		JBrowse link
G NEIL1 nei like DNA glycosylase 1 enables IEA InterPro GO_REF:0000002 NCBI chr26:8,074,706...8,082,437
Ensembl chr26:8,074,310...8,082,123 		JBrowse link
G NEIL2 nei like DNA glycosylase 2 enables IEA InterPro GO_REF:0000002 NCBI chr 8:7,319,721...7,338,683
Ensembl chr 8:7,319,585...7,338,602 		JBrowse link
G NEIL3 nei like DNA glycosylase 3 enables IEA InterPro GO_REF:0000002 NCBI chr 7:123,408,582...123,462,475
Ensembl chr 7:123,409,363...123,462,411 		JBrowse link
G NTHL1 nth like DNA glycosylase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:1,936,415...1,946,468
Ensembl chr 5:1,936,524...1,946,434 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables ISO (PMID:14706345) UniProt
RGD		 PMID:9801319 PMID:14706345 RGD:729091 NCBI chr22:45,757,414...45,763,690 JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables IEA InterPro GO_REF:0000002 Ensembl chr22:45,758,626...45,763,779 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 enables ISO (PMID:22683995), (PMID:26626479), (PMID:26626480), (PMID:27568560), (PMID:30675909), (PMID:32241924), (PMID:32358582), (PMID:37823600) UniProt PMID:22683995 PMID:26626479 PMID:26626480 PMID:27568560 PMID:30675909 More... NCBI chr25:3,350,798...3,405,040 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 enables IEA Ensembl GO_REF:0000107 Ensembl chr25:3,350,821...3,388,826 JBrowse link
G PARP2 poly(ADP-ribose) polymerase 2 enables ISO (PMID:34108479) UniProt PMID:34108479 NCBI chr29:20,862,787...20,877,752
Ensembl chr29:20,863,380...20,877,644 		JBrowse link
G PCNA proliferating cell nuclear antigen enables IEA Ensembl GO_REF:0000107 NCBI chr 2:32,936,600...32,953,635
Ensembl chr 2:32,948,196...32,953,991 		JBrowse link
G POLB DNA polymerase beta ISO RGD PMID:12388548 RGD:633643 NCBI chr 8:40,332,165...40,368,065
Ensembl chr 8:40,332,208...40,372,582 		JBrowse link
G POLH DNA polymerase eta enables IEA InterPro GO_REF:0000002 NCBI chr17:28,548,454...28,585,232
Ensembl chr17:28,549,623...28,585,206 		JBrowse link
G POLI DNA polymerase iota enables IEA InterPro GO_REF:0000002 NCBI chr18:26,644,901...26,670,911
Ensembl chr18:26,641,245...26,670,893 		JBrowse link
G POLK DNA polymerase kappa enables IEA InterPro GO_REF:0000002 NCBI chr 4:69,842,887...69,948,285
Ensembl chr 4:69,872,752...69,948,249 		JBrowse link
G RAD23A RAD23 homolog A, nucleotide excision repair protein enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr 6:11,625,464...11,633,922
Ensembl chr 6:11,625,458...11,637,419 		JBrowse link
G RAD23B RAD23 homolog B, nucleotide excision repair protein enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr12:32,203,501...32,250,555
Ensembl chr12:32,204,893...32,250,570 		JBrowse link
G RBBP8 RB binding protein 8, endonuclease enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr18:57,501,070...57,617,301
Ensembl chr18:57,501,271...57,597,670 		JBrowse link
G RBBP8NL RBBP8 N-terminal like enables IEA TreeGrafter GO_REF:0000118 NCBI chr 2:1,801,775...1,820,209
Ensembl chr 2:1,811,379...1,819,724 		JBrowse link
G REV1 REV1 DNA directed polymerase enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr14:3,128,824...3,218,894
Ensembl chr14:3,129,529...3,218,866 		JBrowse link
G RPA1 replication protein A1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:1,470,375...1,537,603
Ensembl chr16:1,470,474...1,539,246 		JBrowse link
G RPA2 replication protein A2 enables ISO (PMID:27723717), (PMID:27723720), (PMID:7700386) UniProt PMID:7700386 PMID:27723717 PMID:27723720 NCBI chr20:104,882,739...104,904,612 JBrowse link
G RPA2 replication protein A2 enables IEA Ensembl GO_REF:0000107 Ensembl chr20:104,883,027...104,904,951 JBrowse link
G RPA3 replication protein A3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr21:50,570,027...50,574,270
Ensembl chr21:50,570,751...50,574,216 		JBrowse link
G RPS3 ribosomal protein S3 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:66,629,895...66,636,462
Ensembl chr 1:66,629,954...66,635,344 		JBrowse link
G SDE2 SDE2 telomere maintenance homolog enables IEA Ensembl GO_REF:0000107 NCBI chr25:3,779,561...3,793,496
Ensembl chr25:3,779,560...3,795,893 		JBrowse link
G SIRT6 sirtuin 6 enables ISO (PMID:31995034), (PMID:32538779) UniProt PMID:31995034 PMID:32538779 NCBI chr 6:3,924,230...3,932,583
Ensembl chr 6:3,924,230...3,932,590 		JBrowse link
G SMC6 structural maintenance of chromosomes 6 enables IEA TreeGrafter GO_REF:0000118 NCBI chr14:89,917,621...90,005,604
Ensembl chr14:89,917,518...90,000,088 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chr26:39,489,925...39,595,096
Ensembl chr26:39,508,600...39,594,927 		JBrowse link
G TP63 tumor protein p63 enables ISO (PMID:17122775) MGI PMID:17122775 NCBI chr15:83,861,489...84,126,675 JBrowse link
G TP63 tumor protein p63 enables IEA Ensembl GO_REF:0000107 Ensembl chr15:84,093,957...84,123,905 JBrowse link
G UNG uracil DNA glycosylase enables ISO (PMID:18973764) UniProt PMID:18973764 NCBI chr11:104,302,507...104,325,160 JBrowse link
G XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like enables IEA InterPro GO_REF:0000002 NCBI chr 1:63,096,260...63,132,158 JBrowse link
G XPA XPA, DNA damage recognition and repair factor enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr12:41,711,872...41,735,024
Ensembl chr12:41,711,943...41,725,698 		JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr22:50,088,019...50,121,584
Ensembl chr22:50,085,353...50,121,542 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 enables IEA InterPro GO_REF:0000002 NCBI chr 6:37,062,149...37,095,138
Ensembl chr 6:37,060,439...37,095,094 		JBrowse link
G XRCC5 X-ray repair cross complementing 5 enables IEA InterPro GO_REF:0000002 NCBI chr10:101,952,909...102,051,059
Ensembl chr10:101,953,067...102,049,964 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 enables IEA InterPro GO_REF:0000002 NCBI chr19:24,160,459...24,204,237
Ensembl chr19:24,160,483...24,206,320 		JBrowse link
G ZNF432 zinc finger protein 432 enables ISO (PMID:37823600) UniProt PMID:37823600 NCBI chr 6:44,849,946...44,864,224
Ensembl chr 6:44,847,333...44,858,408 		JBrowse link
8-hydroxy-2'-deoxyguanosine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLM BLM RecQ like helicase enables ISO (PMID:19734539) BHF-UCL PMID:19734539 NCBI chr29:9,046,485...9,152,320
Ensembl chr29:9,045,373...9,152,254 		JBrowse link
G POT1 protection of telomeres 1 enables ISO (PMID:19734539) BHF-UCL PMID:19734539 NCBI chr21:93,572,139...93,688,374
Ensembl chr21:93,571,272...93,655,869 		JBrowse link
G WRN WRN RecQ like helicase enables ISO (PMID:19734539) BHF-UCL PMID:19734539 NCBI chr 8:29,150,256...29,288,830
Ensembl chr 8:29,174,229...29,289,129 		JBrowse link
DNA-(abasic site) binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO (PMID:9804798) UniProt PMID:9804798 NCBI chr29:20,978,878...20,981,393 JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific enables ISO (PMID:30554877), (PMID:31235913), (PMID:32492421), (PMID:35450882), (PMID:36608669) UniProt PMID:30554877 PMID:31235913 PMID:32492421 PMID:35450882 PMID:36608669 NCBI chr22:51,759,776...51,785,902
Ensembl chr22:51,759,715...51,785,987 		JBrowse link
oxidized DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XRCC1 X-ray repair cross complementing 1 enables ISO (PMID:28002403) UniProt PMID:28002403 NCBI chr 6:37,062,149...37,095,138
Ensembl chr 6:37,060,439...37,095,094 		JBrowse link
oxidized purine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MSH2 mutS homolog 2 contributes_to
enables		 ISO
IEA		 (PMID:11756455), (PMID:11801590) HGNC
Ensembl		 PMID:11756455 PMID:11801590 GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819 		JBrowse link
G MSH3 mutS homolog 3 NOT|contributes_to ISO (PMID:11756455) HGNC PMID:11756455 NCBI chr 4:74,811,181...75,032,067
Ensembl chr 4:74,811,198...75,032,005 		JBrowse link
G MSH6 mutS homolog 6 contributes_to
enables		 ISO
IEA		 (PMID:11756455), (PMID:11801590) HGNC
Ensembl		 PMID:11756455 PMID:11801590 GO_REF:0000107 NCBI chr14:59,375,602...59,400,252
Ensembl chr14:59,375,691...59,400,174 		JBrowse link
G MUTYH mutY DNA glycosylase enables IEA TreeGrafter GO_REF:0000118 NCBI chr20:87,449,480...87,462,329
Ensembl chr20:87,448,986...87,462,265 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables ISO (PMID:14706345) UniProt PMID:14706345 NCBI chr22:45,757,414...45,763,690 JBrowse link
G RECQL4 RecQ like helicase 4 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:138,725,494...138,732,286
Ensembl chr 8:138,725,633...138,732,096 		JBrowse link
G RPS3 ribosomal protein S3 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:66,629,895...66,636,462
Ensembl chr 1:66,629,954...66,635,344 		JBrowse link
oxidized pyrimidine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPS3 ribosomal protein S3 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:66,629,895...66,636,462
Ensembl chr 1:66,629,954...66,635,344 		JBrowse link
single-strand break-containing DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APTX aprataxin enables IEA TreeGrafter GO_REF:0000118 NCBI chr12:47,239,094...47,346,528
Ensembl chr12:47,258,798...47,287,102 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18050
    binding 16493
      organic cyclic compound binding 5330
        nucleic acid binding 3385
          DNA binding 2176
            damaged DNA binding 70
              DNA-(abasic site) binding 2
              alkylated DNA binding + 0
              oxidized DNA binding + 11
              single-strand break-containing DNA binding 1
paths to the root