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ONTOLOGY REPORT - ANNOTATIONS

Term:heart looping
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Accession:GO:0001947 term browser browse the term
Definition:The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceding septation.
Synonyms:exact_synonym: cardiac looping


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heart looping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in ISO (MGI:5584055|PMID:23603510) BHF-UCL PMID:23603510 MGI:5584055 NCBI chr18:38,878,621...38,882,280
Ensembl chr18:38,878,947...38,886,206 		JBrowse link
G ARL13B ADP ribosylation factor like GTPase 13B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22554696) Ensembl
MGI		 PMID:22554696 GO_REF:0000107 NCBI chr33:1,698,360...1,762,846
Ensembl chr33:1,698,363...1,761,641 		JBrowse link
G ASB2 ankyrin repeat and SOCS box containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:63,008,206...63,051,809
Ensembl chr 8:63,008,575...63,051,581 		JBrowse link
G C2CD3 C2 domain containing 3 centriole elongation regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:24,127,390...24,272,473
Ensembl chr21:24,127,598...24,272,657 		JBrowse link
G CCDC103 coiled-coil domain containing 103 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:18,581,544...18,585,939
Ensembl chr 9:18,582,468...18,584,612 		JBrowse link
G CCDC39 coiled-coil domain 39 molecular ruler complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:13,915,763...13,959,574
Ensembl chr34:13,905,434...13,959,340 		JBrowse link
G CCDC40 coiled-coil domain 40 molecular ruler complex subunit involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:1,616,029...1,656,043
Ensembl chr 9:1,601,121...1,656,597 		JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15750185) Ensembl
MGI		 PMID:15750185 GO_REF:0000107 NCBI chr 1:31,522,911...31,525,342
Ensembl chr 1:31,523,799...31,524,995 		JBrowse link
G CLUAP1 clusterin associated protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23742838) Ensembl
MGI		 PMID:23742838 GO_REF:0000107 NCBI chr 6:37,708,258...37,746,361
Ensembl chr 6:37,708,089...37,746,398 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 involved_in ISO (MGI:2661305|PMID:12730124) BHF-UCL PMID:12730124 MGI:2661305 NCBI chr12:72,265,078...72,272,347
Ensembl chr12:72,265,682...72,272,348 		JBrowse link
G DNAAF1 dynein axonemal assembly factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:68,184,532...68,205,651
Ensembl chr 5:68,184,532...68,205,656 		JBrowse link
G DVL1 dishevelled segment polarity protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:56,507,803...56,519,382
Ensembl chr 5:56,507,739...56,519,491 		JBrowse link
G DVL2 dishevelled segment polarity protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,194,326...32,201,922
Ensembl chr 5:32,194,313...32,201,857 		JBrowse link
G ENG endoglin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064 		JBrowse link
G FGF8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10411502) Ensembl
MGI		 PMID:10411502 GO_REF:0000107 NCBI chr28:14,362,407...14,367,109
Ensembl chr28:14,362,109...14,367,468 		JBrowse link
G FOXH1 forkhead box H1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,883,554...37,887,324
Ensembl chr13:37,882,687...37,885,319 		JBrowse link
G GATA4 GATA binding protein 4 involved_in ISO (MGI:3052615|PMID:15310850) BHF-UCL PMID:15310850 MGI:3052615 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9486664) Ensembl
MGI		 PMID:9486664 GO_REF:0000107 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G HAND1 heart and neural crest derivatives expressed 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9500551) Ensembl
MGI		 PMID:9500551 GO_REF:0000107 NCBI chr 4:55,231,061...55,234,640
Ensembl chr 4:55,231,481...55,234,265 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9171826) Ensembl
MGI		 PMID:9171826 GO_REF:0000107 NCBI chr25:24,140,496...24,143,143
Ensembl chr25:24,141,243...24,152,958 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14659802) Ensembl
MGI		 PMID:14659802 GO_REF:0000107 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692 		JBrowse link
G IFT172 intraflagellar transport 172 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18930042) Ensembl
MGI		 PMID:18930042 GO_REF:0000107 NCBI chr17:21,389,462...21,426,970
Ensembl chr17:21,389,482...21,426,796 		JBrowse link
G IFT52 intraflagellar transport 52 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15930098) Ensembl
MGI		 PMID:15930098 GO_REF:0000107 NCBI chr24:31,295,987...31,334,825
Ensembl chr24:31,296,015...31,334,808 		JBrowse link
G IFT57 intraflagellar transport 57 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17027958) Ensembl
MGI		 PMID:17027958 GO_REF:0000107 NCBI chr33:13,432,902...13,486,692
Ensembl chr33:13,410,544...13,486,612 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,616,942...25,622,989 JBrowse link
G KDM2A lysine demethylase 2A acts_upstream_of_or_within ISO (PMID:25463925) MGI PMID:25463925 NCBI chr18:50,178,511...50,294,097
Ensembl chr18:50,181,024...50,291,127 		JBrowse link
G KIF3A kinesin family member 3A acts_upstream_of_or_within ISO (PMID:10330409) MGI PMID:10330409 NCBI chr11:20,988,516...21,044,151
Ensembl chr11:20,928,655...21,044,090 		JBrowse link
G LBX1 ladybird homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12522123) Ensembl
MGI		 PMID:12522123 GO_REF:0000107 NCBI chr28:13,872,846...13,875,521
Ensembl chr28:13,873,727...13,875,486 		JBrowse link
G LOC609557 cryptic protein acts_upstream_of_or_within ISO (PMID:10521397) MGI PMID:10521397 NCBI chr19:20,318,937...20,384,369 JBrowse link
G LOC609612 folate receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:25,944,350...25,951,010 JBrowse link
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:19795512) MGI PMID:19795512 NCBI chr27:34,003,334...34,166,334
Ensembl chr27:34,003,539...34,161,437 		JBrowse link
G MEF2C myocyte enhancer factor 2C involved_in ISO (MGI:3830899|PMID:16680724) UniProt PMID:16680724 MGI:3830899 NCBI chr 3:19,778,997...19,948,203
Ensembl chr 3:19,779,007...19,943,852 		JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,738,333...52,739,962
Ensembl chr 3:52,738,366...52,739,755 		JBrowse link
G MIB1 MIB E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16000382) Ensembl
MGI		 PMID:16000382 GO_REF:0000107 NCBI chr 7:66,173,414...66,289,477
Ensembl chr 7:66,178,594...66,289,491 		JBrowse link
G NKX2-5 NK2 homeobox 5 acts_upstream_of_or_within ISO (PMID:16510504)
(PMID:7628699), (PMID:9192865)		 MGI PMID:7628699 PMID:9192865 PMID:16510504 NCBI chr 4:39,240,755...39,254,585
Ensembl chr 4:39,244,286...39,247,592 		JBrowse link
G NODAL nodal growth differentiation factor acts_upstream_of_or_within ISO (PMID:16496285) MGI PMID:16496285 NCBI chr 4:21,366,828...21,374,623
Ensembl chr 4:21,367,583...21,375,151 		JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G NOTCH2 notch receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:56,854,825...57,020,157
Ensembl chr17:56,860,429...57,020,857 		JBrowse link
G NOTO notochord homeobox acts_upstream_of_or_within ISO (PMID:17884984) MGI PMID:17884984
G NPHP3 nephrocystin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:29,662,486...29,703,629
Ensembl chr23:29,645,641...29,703,805 		JBrowse link
G OVOL2 ovo like zinc finger 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17573777) Ensembl
MGI		 PMID:17573777 GO_REF:0000107 NCBI chr24:5,020,608...5,050,487
Ensembl chr24:5,020,813...5,050,309 		JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:11,383,441...11,437,603
Ensembl chr32:11,383,424...11,435,438 		JBrowse link
G PSEN1 presenilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10557208) Ensembl
MGI		 PMID:10557208 GO_REF:0000107 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10411502), (PMID:10500184) Ensembl
MGI		 PMID:10411502 PMID:10500184 GO_REF:0000107 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903 		JBrowse link
G SMAD3 SMAD family member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15183723) Ensembl
MGI		 PMID:15183723 GO_REF:0000107 NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337 		JBrowse link
G SMO smoothened, frizzled class receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033 		JBrowse link
G SOX17 SRY-box transcription factor 17 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17610846) Ensembl
MGI		 PMID:17610846 GO_REF:0000107 NCBI chr29:5,979,092...5,981,504
Ensembl chr29:5,979,261...5,981,124 		JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15929941) Ensembl
MGI		 PMID:15929941 GO_REF:0000107 NCBI chr12:11,664,441...11,673,846
Ensembl chr12:11,664,527...11,671,533 		JBrowse link
G STIL STIL centriolar assembly protein acts_upstream_of_or_within ISO (PMID:10385121) MGI PMID:10385121 NCBI chr15:13,369,292...13,431,677
Ensembl chr15:13,371,925...13,430,951 		JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16155214) Ensembl
MGI		 PMID:16155214 GO_REF:0000107 NCBI chr28:14,992,989...15,115,499
Ensembl chr28:14,992,618...15,112,389 		JBrowse link
G TBX2 T-box transcription factor 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:35,237,323...35,245,066
Ensembl chr 9:35,235,649...35,245,736 		JBrowse link
G TBX20 T-box transcription factor 20 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15843407)
(PMID:15901664)		 Ensembl
MGI
TreeGrafter		 PMID:15843407 PMID:15901664 GO_REF:0000107 GO_REF:0000118 NCBI chr14:46,891,706...46,946,899
Ensembl chr14:46,896,228...46,947,507 		JBrowse link
G TBX3 T-box transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18723448)
(PMID:17460765)		 Ensembl
MGI		 PMID:17460765 PMID:18723448 GO_REF:0000107 NCBI chr26:11,694,885...11,709,594
Ensembl chr26:11,696,565...11,708,918 		JBrowse link
G TBX6 T-box transcription factor 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:18,093,201...18,098,592
Ensembl chr 6:18,093,189...18,097,636 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636 		JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (PMID:20178780) MGI PMID:20178780 NCBI chr26:6,039,046...6,047,490
Ensembl chr26:6,039,405...6,047,459 		JBrowse link
G UCP3 uncoupling protein 3 acts_upstream_of_or_within ISO (PMID:19004860) MGI PMID:19004860 NCBI chr21:24,272,522...24,290,304
Ensembl chr21:24,277,896...24,288,639 		JBrowse link
G VANGL2 VANGL planar cell polarity protein 2 involved_in ISO (MGI:2157686|PMID:11440971) UniProt PMID:11440971 MGI:2157686 NCBI chr38:21,822,873...21,824,537 JBrowse link
G WNT3A Wnt family member 3A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16291790) Ensembl
MGI		 PMID:16291790 GO_REF:0000107 NCBI chr14:864,393...899,698
Ensembl chr14:863,424...896,412 		JBrowse link
G WNT5A Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19795512) Ensembl
MGI		 PMID:19795512 GO_REF:0000107 NCBI chr20:34,756,430...34,790,937
Ensembl chr20:34,769,930...34,786,673 		JBrowse link
G ZIC3 Zic family member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16496285)
(PMID:15384171)		 Ensembl
MGI		 PMID:15384171 PMID:16496285 GO_REF:0000107 NCBI chr  X:107,822,002...107,833,582
Ensembl chr  X:107,821,948...107,833,597 		JBrowse link
negative regulation of heart looping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TBX2 T-box transcription factor 2 involved_in ISO (MGI:3039059|PMID:15042700) BHF-UCL PMID:15042700 MGI:3039059 NCBI chr 9:35,237,323...35,245,066
Ensembl chr 9:35,235,649...35,245,736 		JBrowse link
regulation of heart looping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RNF207 ring finger protein 207 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:60,105,200...60,119,902
Ensembl chr 5:60,106,297...60,118,670 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    developmental process 6840
      anatomical structure morphogenesis 3003
        embryonic morphogenesis 702
          embryonic heart tube morphogenesis 69
            heart looping 62
              negative regulation of heart looping 1
              positive regulation of heart looping 0
              regulation of heart looping + 2
Path 2
Term Annotations click to browse term
  biological_process 17925
    developmental process 6840
      anatomical structure development 6424
        multicellular organism development 5184
          system development 4514
            circulatory system development 1359
              heart development 737
                embryonic heart tube development 94
                  embryonic heart tube morphogenesis 69
                    heart looping 62
                      negative regulation of heart looping 1
                      positive regulation of heart looping 0
                      regulation of heart looping + 2
paths to the root