ENG (endoglin) - Rat Genome Database

Name: ENG
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: ENG (endoglin) Canis lupus familiaris

Analyze

Symbol:

ENG

Name:

endoglin

RGD ID:

12248301

Description:

ENCODES a protein that exhibits BMP binding (ortholog); type II transforming growth factor beta receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); bone development (ortholog); cardiac jelly development (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); arteriovenous malformation (ortholog); arteriovenous malformations of the brain (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

endoglin (Osler-Rendu-Weber syndrome 1)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ENG (endoglin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Eng (endoglin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Eng (endoglin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Eng (endoglin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ENG (endoglin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Eng (endoglin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ENG (endoglin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ENG (endoglin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Eng (endoglin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	55,558,246 - 55,590,081 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	55,558,305 - 55,589,064 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	54,752,221 - 54,783,620 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	56,480,195 - 56,511,601 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	56,480,054 - 56,511,589 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	55,240,157 - 55,271,556 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	55,554,890 - 55,586,290 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	55,646,354 - 55,677,713 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

arteriovenous malformation (ISO)

arteriovenous malformations of the brain (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

clear cell renal cell carcinoma (ISO)

congenital disorder of glycosylation Iu (ISO)

congestive heart failure (ISO)

coronary artery disease (ISO)

cystic fibrosis (ISO)

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 31A (ISO)

Diabetic Nephropathies (ISO)

diabetic retinopathy (ISO)

early infantile epileptic encephalopathy (ISO)

Epistaxis (ISO)

Experimental Radiation Injuries (ISO)

Galloway-Mowat syndrome 1 (ISO)

genetic disease (ISO)

GNE myopathy (ISO)

hepatocellular carcinoma (ISO)

hereditary hemorrhagic telangiectasia (ISO)

Hereditary Hemorrhagic Telangiectasia, Type 1 (ISO)

Hereditary Hemorrhagic Telangiectasia, Type 2 (ISO)

Hypercholesterolemia (ISO)

hypertension (ISO)

interstitial lung disease (ISO)

intracranial aneurysm (ISO)

juvenile polyposis syndrome (ISO)

Kidney Reperfusion Injury (ISO)

Leber congenital amaurosis (ISO)

lymphoid leukemia (ISO)

melanoma (ISO)

middle cerebral artery infarction (ISO)

Moyamoya Disease 2 (ISO)

multiple myeloma (ISO)

pre-eclampsia (ISO)

Pregnancy in Diabetics (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Primary Pulmonary Hypertension, 1 (ISO)

prostate cancer (ISO)

Pulmonary Arterial Hypertension (ISO)

Pulmonary Arterial Hypertension, Hereditary Hemorrhagic Telangiectasia-Related (ISO)

pulmonary hypertension (ISO)

renal fibrosis (ISO)

Right Ventricular Hypertrophy (ISO)

secondary hyperparathyroidism (ISO)

Stress Fractures (ISO)

systemic lupus erythematosus (ISO)

Wounds and Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA,ISO)

artery morphogenesis (IEA)

atrial cardiac muscle tissue morphogenesis (IEA)

atrioventricular canal morphogenesis (IEA)

bone development (ISO)

branching involved in blood vessel morphogenesis (IEA)

cardiac atrium morphogenesis (IEA)

cardiac jelly development (ISO)

cardiac ventricle morphogenesis (IEA)

cell chemotaxis (ISO)

cell migration (IBA,IEA)

cell migration involved in endocardial cushion formation (IEA,ISO)

cell motility (ISO)

cellular response to mechanical stimulus (ISO)

central nervous system vasculogenesis (IEA)

detection of hypoxia (ISO)

dorsal aorta morphogenesis (IEA)

endocardial cushion morphogenesis (IEA)

endocardial cushion to mesenchymal transition (ISO)

epithelial to mesenchymal transition (IBA,IEA)

epithelial to mesenchymal transition involved in endocardial cushion formation (IEA)

extracellular matrix constituent secretion (ISO)

extracellular matrix disassembly (ISO)

heart development (IEA,ISO)

heart looping (IEA)

negative regulation of cell migration (IEA)

negative regulation of endothelial cell proliferation (ISO)

negative regulation of gene expression (IEA)

negative regulation of transcription by RNA polymerase II (ISO)

outflow tract septum morphogenesis (IEA)

positive regulation of angiogenesis (IEA,ISO)

positive regulation of BMP signaling pathway (IEA)

positive regulation of collagen biosynthetic process (ISO)

positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation (IEA)

positive regulation of gene expression (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

positive regulation of protein phosphorylation (ISO)

positive regulation of SMAD protein signal transduction (IEA)

positive regulation of systemic arterial blood pressure (ISO)

positive regulation of transcription by RNA polymerase II (IEA)

positive regulation of vascular associated smooth muscle cell differentiation (IEA)

regulation of cardiac muscle cell apoptotic process (ISO)

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis (ISO)

regulation of cell proliferation involved in heart morphogenesis (ISO)

regulation of DNA-templated transcription (IEA)

regulation of transforming growth factor beta receptor signaling pathway (IBA,IEA,ISO)

response to hypoxia (ISO)

response to transforming growth factor beta (ISO)

response to xenobiotic stimulus (ISO)

smooth muscle tissue development (IEA)

sprouting angiogenesis (ISO)

transforming growth factor beta receptor signaling pathway (IBA,IEA,ISO)

vascular associated smooth muscle cell development (IEA)

vasculogenesis (IBA,IEA,ISO)

venous blood vessel morphogenesis (IEA)

ventricular trabecula myocardium morphogenesis (IEA)

wound healing (ISO)

Cellular Component

cell surface (IEA,ISO)

endothelial microparticle (IEA)

external side of plasma membrane (IEA)

extracellular space (IEA,ISO)

membrane (IEA)

nuclear body (IEA)

plasma membrane (IEA)

receptor complex (IEA)

Molecular Function

BMP binding (IEA,ISO)

coreceptor activity (IEA)

galactose binding (IEA)

glycosaminoglycan binding (IBA,IEA)

identical protein binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

signaling receptor activator activity (IEA)

transforming growth factor beta binding (IBA,IEA)

transforming growth factor beta receptor activity (IBA,IEA)

type I transforming growth factor beta receptor binding (IEA)

type II transforming growth factor beta receptor binding (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

ENG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	55,558,246 - 55,590,081 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	55,558,305 - 55,589,064 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	54,752,221 - 54,783,620 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	56,480,195 - 56,511,601 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	56,480,054 - 56,511,589 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	55,240,157 - 55,271,556 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	55,554,890 - 55,586,290 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	55,646,354 - 55,677,713 (+)	NCBI		UU_Cfam_GSD_1.0

ENG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	127,815,016 - 127,854,658 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	127,815,013 - 127,854,658 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	130,577,291 - 130,617,052 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	129,617,115 - 129,656,805 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	127,656,849 - 127,696,538	NCBI
Celera	9	101,228,133 - 101,267,888 (-)	NCBI		Celera
Cytogenetic Map	9	q34.11	NCBI
HuRef	9	100,194,111 - 100,234,515 (-)	NCBI		HuRef
CHM1_1	9	130,728,823 - 130,768,983 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	140,022,435 - 140,062,072 (-)	NCBI		T2T-CHM13v2.0

Eng
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	32,536,607 - 32,572,681 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	32,536,607 - 32,572,681 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	32,646,595 - 32,682,669 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	32,646,595 - 32,682,669 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	32,502,115 - 32,538,189 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	32,468,604 - 32,504,127 (+)	NCBI		MGSCv36	mm8
Celera	2	32,353,177 - 32,389,276 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	22.09	NCBI

Eng
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	36,332,190 - 36,370,324 (+)	NCBI		GRCr8
mRatBN7.2	3	15,934,566 - 15,972,618 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	15,934,518 - 15,973,230 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	19,003,353 - 19,041,237 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	27,588,363 - 27,626,245 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	25,839,360 - 25,877,319 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	11,679,530 - 11,717,486 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	11,679,530 - 11,717,485 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	17,021,673 - 17,058,548 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	3	10,675,660 - 10,713,537 (+)	NCBI		Celera
Cytogenetic Map	3	p11	NCBI

Eng
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	818,932 - 852,694 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	818,797 - 853,319 (+)	NCBI	ChiLan1.0	ChiLan1.0

ENG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	11,500,636 - 11,540,554 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	11,502,983 - 11,542,901 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	98,934,080 - 98,973,862 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	127,605,608 - 127,644,641 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	127,605,608 - 127,644,641 (-)	Ensembl	panpan1.1		panPan2

Eng
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	195,698,638 - 195,730,666 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	15,467,835 - 15,477,488 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	15,467,165 - 15,499,180 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	268,309,400 - 268,343,783 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	268,309,379 - 268,343,861 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	302,232,063 - 302,266,139 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ENG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	10,274,705 - 10,315,715 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	10,275,064 - 10,315,040 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666079	5,905,669 - 5,949,288 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eng
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	7,703,820 - 7,734,457 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	7,703,979 - 7,735,636 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ENG
395 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	3	5	18	6	6	6	5	6	2		10	6
Low	2		4				1		10	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005625330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038487337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038549266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038613209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LC536032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LC536033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000046384 ⟹ ENSCAFP00000041587

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	55,558,305 - 55,589,064 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845009485 ⟹ ENSCAFP00845007415

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	56,480,054 - 56,511,589 (+)	Ensembl

RefSeq Acc Id:

XM_005625330 ⟹ XP_005625387

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	55,558,246 - 55,590,081 (+)	NCBI
Dog10K_Boxer_Tasha	9	54,752,221 - 54,783,620 (+)	NCBI

Sequence:

show sequence

TGCCTCCCAGGCCGGCCTGGATGAGCCCGGAGCTCCCCACCGCTGCCTGTCAGACCCCCCAGCC
TCCAGCTGCATCCCCAGGCCCGGACCTGCCGCTGCCGCCTCCGCCTCCACCGCCCCAGGCCCCG
GCACCCCCGCCCTGCTCATCCTCTGGCCGTGACCCCCGGCCGGCCCGGCGCCCCTGTGCCCACT
TCTCCTGACCCCTCCGCCGCCACCTCAGAAGGCTGGAGCGGGGACGCCGTCGCTCCGGCCGCCT
GTTCCCCTCGGGTCCCCGCTCGCGCCCACGCCGGCCCCCACACCCACCCGCAGCCCTGCCCCTG
GACACCGGATAAGGCCCCGTGCGCAGACCCCCTGGTGGACCGCATGGACCGCACCGCGCTTCCC
CTGGTCGTCGCCCTACTCCTGGCCATCTGCAGCCTCAGACATACAGGTCTTGCAGAAACAATCC
ATTGTGACTTACAGCCTGTGGACGCCGAGGTGACATACATTACAAGTCAGGTTTCTGAGGGCTG
CGTGGCTCAGGTCCCCAATGCTACCGTGGAAGTTCATATTCTCTTCCTGGAATCCTCAAGGGAG
CTGTCAGAGCTGGAGCTGACTATCCAGAAGTCCAAGCAAAATGGCACTCGGCCCCGAGAGGTGT
TCCTGGTCCTCAGTGCAAAGAAGAATGTGCTTCTGCAGTTGCAGGCCCCAGGAATCCCACTCTA
CCTGGCCTTCAACCCCAAACTGATCTTCCAAGGGCACCCAGGAGTCAACACCACGGAACTGCCA
TCCTTCACCACCAAGAGCCAGCTCCTCGCCTGGGCGGATACCAAGGGCTCCATTGCGTCTATCG
CTGAGCTGAATGACCCTCAAAGCATCCTCCTCCGTCTGGACCAAGCCCCGAAATCACCGTCCTT
CTGCAATCTGGAACCCCTCGTGGACATGGGCCACACACTTGAGTGGAGCCCGCTCACCCGGGCC
TCTGTCCGGGGCTGCCGTTTGGAAGGCGTGCCTGGCCACAAGGAAGCGCACATCGTGAGGGTCC
TACCAGGCCCGGAGGCCGGGCCCCGGACAGTGACCGTGAAGGTGGAGCTGCGCTGTGCTTCCGG
TGATCCCGAAGCTGTGCTTATCCTGCAAGGTCCATCCCATGTGTCCTGGCTCATCGACGCCAAC
CACAACATGCAGATCTGGACCACTGGTGAATACTCCTTCAAGATCTTTCCAGAGAAGAACATCC
GTGGCTTTGTGCTCCCAGATACACCCCAAGGCCTGCTGGGGGAGGCCCGGAGACTCAACGCCAG
CATGGTAGCATCCTTCGTGGAGCTCCCCCTGGCCAGTGTCGTCTCGCTGCAGGCCCACAGCTGC
GGTGGTGGTGGGCTGCAGACCTCTCCCCCACCTGTCCAGACCACCCCTCCTCCCACGGAGAGCT
GCAACCAAGAGCTGCTCCTGTCCCTGATCCAGCCCAAGTGCTCTGAAGACGTCATGACTGTGGT
GCTCAAGAAAGACCTCATCTCGACACTGCGGTGCACCATCATGAGCCTGACCTTCTCAGACCCC
AGCTGCCAGGCTGAGGACAGAGATGACCAGTTTGTCCTGCGCAGCACTTACTCCAGCTGTGGCA
TGGCAGTGACAGAAAACGTGGTCAGTAATGAGGTGGTCGTCAACCTCTTCCCAAGCTCTTCACT
GCAGTGGAAGAAGGTTCACTGCATCAACATGGAGAGCCTCTCCTTCCAGCTGGGCCTGTACCTC
AGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCTGGGGCAGCAGGGCTTTGTGCAGGTGA
GCATGACCCCATCGATCCCAGAGCTCACGCTGCAGCTAGACAGCTGCCAACTGGATTTGGGGCC
TGAGGGAGACACCGTGGAACTCATCCAGAGCCAGACAGCTAAGGGCAGCTGTGTAAGCCTACTG
TCCCCAGGCCCTGGTGGTGATGTGCGCTTCAGCTTCCTCCTCCGTGGCTACATGGTGCCCACAC
CCACAACTGGCACCCTTACCTGCACCGTAGCCCTGCGTTCGAGGAGTCTGTCACCGGAAACCCA
CAGAACTATCTCCATGCGTCTGAACATCGTCAGCCCTGGCCTGCCTGACAAAGGCCTTGTCCTG
CCCGCTGTGCTGGGTATCACCTTTGGCGCCTTCCTCATTGGGGCCCTGCTCACTGCTGCACTCT
GGTACATCTACTCGCACACGCGTCCCCCTGGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCC
GGCCTCCTCAGAGAGCAGTAGCACCAACCACAGCATCGGGAGCACCCAGAGCACCCCCTGCTCC
ACCAGCAGCATGGCGTAGCACCCGGCCCGGAGACCTGGGGGCCCCCCAGCCAGCCCTCGCCCAG
CAGGAGAGACTGAGCAGCCACCAGCTGGGAACCACTGGCCATGAACTTATCCCGGGACCCCAAC
CCCTCCACTCGACCAAGGATGGACCATGCCCTCTGCGCCCACCCCTCCTGCCTCCCTCTCAGAG
GCCTGCTGCCAGCGGGGGCACCAGCTTGGAACACCTTGGGGTCCCCCCACCCCACCCCCTAGAA
CCTGCAAACCCAGTGGGCCTGGAATATGACTGCCCAGGACCACGGAGAGAGAGACCACTGCCCT
ATAAGTCCACACTATTGTAGAAACCAAGTTCTTGTCATTTTAACCTGGATCCAGCACTTGGTGA
CCTGGGCTGGGTGGGAGGGGAGAATTCAAAACAGACTCACCCAGCCCACCCAGGCCTCCTCCAA
GGAAACAGAAGAAGGCTAGCCCAGAGCCCCCTGGACCTGCTCCCTTCACACCCGGACTGGCACG
ACTTTGGCAAGGGAAACAGAAGCCTAGGGGTGCCCAGCCTGAGAACAGGAGAGCCTAGCTCCTC
TCTACAACTGTCACATGGAGACCCCAAGGCAGGCATCAGCTGGGAAGTGGCCTGTCTGGCCTGG
ACCCACCCCTATATACTCACCACCAATAAATCAGACCATGAAATCAGTGCTGGGCTGGGCCAGA
AGAAAGAATGGGAAGCCTAAAATGGGTGGGGAGGTGACAGCTCTGGGTTCAAATCCTGAAGCTG
CTGCATAATTGGCTGTGTGACTGTGGGCAGGTTCCATGGCTTCTTGAAACCAGCCAGTTGCCTC
AGTTGGAACAAGGTCTCTGTGGGGAGGTCTACAAAGCAATGCCTGGCCTGAGGCCAACAGACAT
TAGTCCACGGTTCTCATTTCAGACAGGCCTCCTGAGACTTGGGAGGAGGGGCTCCCACCGAGTC
CAGTTCCTGTGCCAGCTGCAGCCCTCACCCTACCGTGTGCTAAGGGCGCTAGGGATCAAGAGTC
GATCAAACTTT

hide sequence

RefSeq Acc Id:

XM_038487337 ⟹ XP_038343265

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	55,240,157 - 55,271,556 (+)	NCBI

RefSeq Acc Id:

XM_038549266 ⟹ XP_038405194

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	9	55,646,354 - 55,677,713 (+)	NCBI

RefSeq Acc Id:

XM_038613209 ⟹ XP_038469137

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	55,554,890 - 55,586,290 (+)	NCBI

RefSeq Acc Id:

XM_038678496 ⟹ XP_038534424

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	56,480,195 - 56,511,601 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005625387	(Get FASTA)	NCBI Sequence Viewer
	XP_038343265	(Get FASTA)	NCBI Sequence Viewer
	XP_038405194	(Get FASTA)	NCBI Sequence Viewer
	XP_038469137	(Get FASTA)	NCBI Sequence Viewer
	XP_038534424	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BCD44937	(Get FASTA)	NCBI Sequence Viewer
	BCD44938	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000041587.1
	ENSCAFP00000070379.1
	ENSCAFP00000074873.1
	ENSCAFP00030018822.1
	ENSCAFP00030018915.1
	ENSCAFP00040026350.1
	ENSCAFP00040026414.1
	ENSCAFP00040026513.1
	ENSCAFP00845007415
	ENSCAFP00845007415.1

RefSeq Acc Id:

XP_005625387 ⟸ XM_005625330

- UniProtKB:

J9P7F0 (UniProtKB/TrEMBL), A0A8C0KVA4 (UniProtKB/TrEMBL), A0A8C0N817 (UniProtKB/TrEMBL), A0A8C0SW25 (UniProtKB/TrEMBL), A0A8P0PSA0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDRTALPLVVALLLAICSLRHTGLAETIHCDLQPVDAEVTYITSQVSEGCVAQVPNATVEVHIL
FLESSRELSELELTIQKSKQNGTRPREVFLVLSAKKNVLLQLQAPGIPLYLAFNPKLIFQGHPG
VNTTELPSFTTKSQLLAWADTKGSIASIAELNDPQSILLRLDQAPKSPSFCNLEPLVDMGHTLE
WSPLTRASVRGCRLEGVPGHKEAHIVRVLPGPEAGPRTVTVKVELRCASGDPEAVLILQGPSHV
SWLIDANHNMQIWTTGEYSFKIFPEKNIRGFVLPDTPQGLLGEARRLNASMVASFVELPLASVV
SLQAHSCGGGGLQTSPPPVQTTPPPTESCNQELLLSLIQPKCSEDVMTVVLKKDLISTLRCTIM
SLTFSDPSCQAEDRDDQFVLRSTYSSCGMAVTENVVSNEVVVNLFPSSSLQWKKVHCINMESLS
FQLGLYLSPHFLQASNTIELGQQGFVQVSMTPSIPELTLQLDSCQLDLGPEGDTVELIQSQTAK
GSCVSLLSPGPGGDVRFSFLLRGYMVPTPTTGTLTCTVALRSRSLSPETHRTISMRLNIVSPGL
PDKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRPPGKREPVVAVAAPASSESSSTNHSIGS
TQSTPCSTSSMA

hide sequence

RefSeq Acc Id:

ENSCAFP00000041587 ⟸ ENSCAFT00000046384

RefSeq Acc Id:

XP_038343265 ⟸ XM_038487337

RefSeq Acc Id:

XP_038469137 ⟸ XM_038613209

RefSeq Acc Id:	XP_038534424 ⟸ XM_038678496
- UniProtKB:	A0A8C0KVA4 (UniProtKB/TrEMBL), A0A8C0N817 (UniProtKB/TrEMBL), J9P7F0 (UniProtKB/TrEMBL), A0A8C0SW25 (UniProtKB/TrEMBL), A0A8P0PSA0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038405194 ⟸ XM_038549266
- UniProtKB:	A0A8C0KVA4 (UniProtKB/TrEMBL), A0A8C0N817 (UniProtKB/TrEMBL), A0A8C0SW25 (UniProtKB/TrEMBL), A0A8P0PSA0 (UniProtKB/TrEMBL), J9P7F0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845007415 ⟸ ENSCAFT00845009485

Protein Domains

Promoters

RGD ID:

13684830

Promoter ID:

EPDNEW_C2898

Type:

multiple initiation site

Name:

ENG_1

Description:

endoglin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	55,558,238 - 55,558,298	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000020106	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030011679	UniProtKB/TrEMBL
	ENSCAFG00040016438	UniProtKB/TrEMBL
	ENSCAFG00845005326	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000046384.4	UniProtKB/TrEMBL
	ENSCAFT00000097453.1	UniProtKB/TrEMBL
	ENSCAFT00000104021.1	UniProtKB/TrEMBL
	ENSCAFT00030021590.1	UniProtKB/TrEMBL
	ENSCAFT00030021696.1	UniProtKB/TrEMBL
	ENSCAFT00040030322.1	UniProtKB/TrEMBL
	ENSCAFT00040030395.1	UniProtKB/TrEMBL
	ENSCAFT00040030504.1	UniProtKB/TrEMBL
	ENSCAFT00845009485	ENTREZGENE
	ENSCAFT00845009485.1	UniProtKB/TrEMBL
Gene3D-CATH	Zona pellucida, ZP-N domain	UniProtKB/TrEMBL
InterPro	ZP_dom	UniProtKB/TrEMBL
KEGG Report	cfa:609166	UniProtKB/TrEMBL
NCBI Gene	ENG	ENTREZGENE
PANTHER	ENDOGLIN	UniProtKB/TrEMBL
	ENDOGLIN/TGF-BETA RECEPTOR TYPE III	UniProtKB/TrEMBL
Pfam	Zona_pellucida	UniProtKB/TrEMBL
UniProt	A0A8C0KVA4	ENTREZGENE
	A0A8C0N817	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0SW25	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0YZZ3_CANLF	UniProtKB/TrEMBL
	A0A8P0PSA0	ENTREZGENE
	J9P7F0	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A8P0PK16	UniProtKB/TrEMBL
	A0A8P0PSA0	UniProtKB/TrEMBL
VGNC ID	VGNC:40362	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)