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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:melancholic depression
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Accession:DOID:1595 term browser browse the term
Definition:A major depressive disorder characterized by near-complete absence of pleasure. (DO)
Synonyms:exact_synonym: clinical depression;   endogenous depression;   endogenous depressions;   major depressive disorder with melancholic features;   melancholia;   melancholias
 alt_id: DOID:2848
 xref: EFO:1002014;   NCI:C34532;   NCI:C34812;   NCI:C35094
For additional species annotation, visit the Alliance of Genome Resources.


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melancholic depression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disc1 DISC1 scaffold protein ISS OMIM:608516 MouseDO NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778 		JBrowse link
G Hap1 huntingtin-associated protein 1 ISS OMIM:608516 MouseDO NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Morc1 MORC family CW-type zinc finger 1 ISS OMIM:608516 MouseDO NCBI chr11:52,178,769...52,384,255
Ensembl chr11:52,178,769...52,384,255 		JBrowse link
G Tph2 tryptophan hydroxylase 2 ISS OMIM:608516 MouseDO NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424 		JBrowse link
postpartum depression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabrd gamma-aminobutyric acid type A receptor subunit delta ISS MouseDO NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411 		JBrowse link
G Il10 interleukin 10 IEP RGD PMID:17033197 RGD:1598630 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:15544576 RGD:1580465 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      nervous system disease 14059
        central nervous system disease 12398
          brain disease 11633
            disease of mental health 8300
              cognitive disorder 2300
                mood disorder 289
                  depressive disorder 200
                    major depressive disorder 63
                      melancholic depression 7
                        postpartum depression 3
paths to the root