Gene: Tph2 (tryptophan hydroxylase 2) Rattus norvegicus
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Symbol: Tph2
Name: tryptophan hydroxylase 2
Description: ENCODES a protein that exhibits tryptophan 5-monooxygenase activity (ortholog); INVOLVED IN cellular response to lithium ion; circadian rhythm; response to activity; PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH Attention Deficit Disorder with Hyperactivity (ortholog); attention deficit hyperactivity disorder (ortholog); Autistic Disorder (ortholog); FOUND IN neuron projection (ortholog); INTERACTS WITH 17beta-estradiol; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: neuronal tryptophan hydroxylase; Ntph; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2
Orthologs:
Homo sapiens (human) : TPH2 (tryptophan hydroxylase 2)  HGNC  AGR
Mus musculus (house mouse) : Tph2 (tryptophan hydroxylase 2)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Tph2 (tryptophan hydroxylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TPH2 (tryptophan hydroxylase 2)
Canis lupus familiaris (dog) : TPH2 (tryptophan hydroxylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tph2 (tryptophan hydroxylase 2)
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Allele / Splice: Tph2em2Mcwi   Tph2em3Mcwi  
Genetic Models: DA-Tph2em3Mcwi DA-Tph2em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0758,042,279 - 58,149,220 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0758,053,268 - 58,157,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4754,321,033 - 54,430,706 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1754,341,665 - 54,451,339 (-)NCBI
Celera747,478,282 - 47,582,240 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tph2
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631332
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE