Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Acute Coronary Syndrome
go back to main search page
Accession:DOID:9001686 term browser browse the term
Definition:An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
Synonyms:exact_synonym: acute coronary syndromes
 related_synonym: factor XII polymorphism
 primary_id: MESH:D054058
 xref: EFO:0005672

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
Acute Coronary Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actg1 actin gamma 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955506:1,546,678...1,549,611
Ensembl chrNW_004955506:1,546,678...1,552,105 		JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO protein:increased expression:serum (human) RGD PMID:21663912 RGD:5508825 NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479 		JBrowse link
G Alb albumin treatment ISO RGD PMID:20716836 RGD:11036086 NCBI chrNW_004955447:9,327...21,212 JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955413:11,670,889...11,688,357
Ensembl chrNW_004955413:11,670,687...11,688,611 		JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955452:34,454...168,514
Ensembl chrNW_004955452:30,589...169,693 		JBrowse link
G Ccn1 cellular communication network factor 1 susceptibility ISO DNA:SNP,haplotypes:5'utr: (rs6576776) (human) RGD PMID:33906697 RGD:329845569 NCBI chrNW_004955423:8,416,498...8,419,029
Ensembl chrNW_004955423:8,413,725...8,419,166 		JBrowse link
G Cd40 CD40 molecule ISO DNA:SNP:5' utr:rs1883832 (human) RGD PMID:21091218 RGD:5490523 NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093 		JBrowse link
G Cd40lg CD40 ligand treatment ISO associated with Anxiety Disorders;protein:increased expression:serum RGD PMID:20170788 PMID:31624788 RGD:21081509 RGD:5490548 NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746 		JBrowse link
G Ckb creatine kinase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:15966572 NCBI chrNW_004955538:2,379,868...2,380,771 JBrowse link
G Ckm creatine kinase, M-type ISO CTD Direct Evidence: marker/mechanism CTD PMID:15966572 NCBI chrNW_004955555:2,318,072...2,330,733
Ensembl chrNW_004955555:2,318,072...2,336,811 		JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955486:4,275,371...4,287,152
Ensembl chrNW_004955486:4,274,238...4,289,809 		JBrowse link
G F12 coagulation factor XII ISO ClinVar Annotator: match by term: FACTOR XII POLYMORPHISM ClinVar PMID:9490684 PMID:11843842 PMID:20303064 PMID:24033266 PMID:25741868 NCBI chrNW_004955408:29,644,279...29,665,161
Ensembl chrNW_004955408:29,642,096...29,650,950 		JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:21496882 RGD:5147784 NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517 		JBrowse link
G Fasn fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23305094 NCBI chrNW_004955506:1,063,002...1,079,939
Ensembl chrNW_004955506:1,063,002...1,079,939 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase susceptibility ISO DNA:SNP: :rs17817449 (human) RGD PMID:20362563 RGD:329813083 NCBI chrNW_004955433:11,424,069...11,834,955
Ensembl chrNW_004955433:11,424,176...11,813,771 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955413:4,162,467...4,166,783
Ensembl chrNW_004955413:4,162,467...4,166,783 		JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO DNa:SNP: :rs3783637 (human) RGD PMID:26232608 RGD:329961571 NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO mRNA, protein:increased expression:blood, plasma RGD PMID:28298473 RGD:401827171 NCBI chrNW_004955532:1,298,336...1,298,830 JBrowse link
G Gpx3 glutathione peroxidase 3 ISO mRNA, protein:increased expression:blood, plasma RGD PMID:28298473 RGD:401827171 NCBI chrNW_004955408:2,622,162...2,629,088
Ensembl chrNW_004955408:2,622,741...2,629,032 		JBrowse link
G Gpx4 glutathione peroxidase 4 ISO mRNA, protein:increased expression:blood, plasma RGD PMID:28298473 RGD:401827171 NCBI chrNW_004955495:6,767,969...6,772,256
Ensembl chrNW_004955495:6,767,975...6,772,178 		JBrowse link
G Gsn gelsolin ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955419:6,682,202...6,733,361
Ensembl chrNW_004955419:6,682,058...6,733,361 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955412:23,863,513...23,867,984
Ensembl chrNW_004955412:23,862,590...23,867,984 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419 		JBrowse link
G Il6 interleukin 6 treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (human)		 CTD
RGD		 PMID:23305094 PMID:32178736 RGD:155230830 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Itgb3 integrin subunit beta 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15840736 NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746 		JBrowse link
G Ldhb lactate dehydrogenase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955413:17,264,337...17,283,530
Ensembl chrNW_004955413:17,261,118...17,283,593 		JBrowse link
G LOC102029877 tubulin alpha-1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955500:8,083,239...8,092,137 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase susceptibility ISO DNA:SNP,haplotype: :p.S326C (rs1052133) (human) RGD PMID:23368530 RGD:401827273 NCBI chrNW_004955561:1,277,362...1,282,949
Ensembl chrNW_004955561:1,277,365...1,282,793 		JBrowse link
G Pappa pappalysin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11586954 NCBI chrNW_004955419:11,415,666...11,645,994
Ensembl chrNW_004955419:11,420,638...11,646,145 		JBrowse link
G Pdia3 protein disulfide isomerase family A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955416:10,197,957...10,221,104
Ensembl chrNW_004955416:10,198,099...10,220,792 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:increased expression:coronary artery, intima (human) RGD PMID:22336504 RGD:6767292 NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 exacerbates ISO protein:increased expression:monocyte (human) RGD PMID:32857129 RGD:401900689 NCBI chrNW_004955465:1,395,418...1,915,820
Ensembl chrNW_004955465:1,395,088...1,913,847 		JBrowse link
G Pla2g7 phospholipase A2 group VII disease_progression ISO RGD PMID:22024276 RGD:6482773 NCBI chrNW_004955437:11,534,251...11,577,942
Ensembl chrNW_004955437:11,534,173...11,555,996 		JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26241956 NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339 		JBrowse link
G Psmb1 proteasome 20S subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955411:3,285,610...3,304,210
Ensembl chrNW_004955411:3,286,835...3,304,931 		JBrowse link
G Rab7b RAB7B, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955406:41,615,302...41,638,157
Ensembl chrNW_004955406:41,615,302...41,638,151 		JBrowse link
G Rbp4 retinol binding protein 4 onset
severity		 ISO protein:increased expression:blood serum (human)
protein:increased expression:blood plasma (human)		 RGD PMID:25437889 PMID:32449048 RGD:329845573 RGD:329845576 NCBI chrNW_004955507:112,342...120,050
Ensembl chrNW_004955507:108,669...120,584 		JBrowse link
G S100b S100 calcium binding protein B ISO protein:increased expression:serum RGD PMID:21663912 RGD:5508825 NCBI chrNW_004955407:42,972,584...42,980,510
Ensembl chrNW_004955407:42,972,584...42,980,510 		JBrowse link
G Serpinc1 serpin family C member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:7923645 NCBI chrNW_004955406:14,024,183...14,036,206
Ensembl chrNW_004955406:14,024,313...14,035,948 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
G Tlr4 toll like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tnf tumor necrosis factor treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (human) 		CTD
RGD		 PMID:20981132 PMID:32178736 RGD:155230830 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Tnni3 troponin I3, cardiac type ISO CTD Direct Evidence: marker/mechanism CTD PMID:15966572 NCBI chrNW_004955567:1,037,325...1,042,102
Ensembl chrNW_004955567:1,037,462...1,042,039 		JBrowse link
G Tnnt2 troponin T2, cardiac type ISO CTD Direct Evidence: marker/mechanism CTD PMID:15966572 NCBI chrNW_004955406:37,491,462...37,507,360
Ensembl chrNW_004955406:37,487,154...37,507,639 		JBrowse link
G Tpm4 tropomyosin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955524:1,419,061...1,432,114
Ensembl chrNW_004955524:1,415,848...1,432,139 		JBrowse link
G Tubb1 tubulin beta 1 class VI ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955445:569,504...576,129
Ensembl chrNW_004955445:569,504...576,345 		JBrowse link
G Vcl vinculin ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955437:17,812,998...17,920,253
Ensembl chrNW_004955437:17,813,007...17,920,253 		JBrowse link
G Vim vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:21751358 NCBI chrNW_004955429:10,708,852...10,716,743
Ensembl chrNW_004955429:10,707,719...10,717,554 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14195
    syndrome 9376
      Acute Coronary Syndrome 50
Path 2
Term Annotations click to browse term
  disease 14195
    disease of anatomical entity 13850
      cardiovascular system disease 4080
        vascular disease 2857
          ischemia 1283
            Myocardial Ischemia 794
              Acute Coronary Syndrome 50
paths to the root