Rbp4 (retinol binding protein 4) - Rat Genome Database

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Gene: Rbp4 (retinol binding protein 4) Chinchilla lanigera
Analyze
Symbol: Rbp4
Name: retinol binding protein 4
RGD ID: 8939243
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); retinol binding (ortholog); INVOLVED IN cardiac muscle tissue development (ortholog); detection of light stimulus involved in visual perception (ortholog); embryonic organ morphogenesis (ortholog); PARTICIPATES IN retinoic acid metabolic pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute pyelonephritis (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinol binding protein 4, plasma; retinol-binding protein 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955507108,669 - 120,584 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955507112,342 - 120,050 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute pyelonephritis  (ISO)
Alcoholic Liver Diseases  (ISO)
Animal Mammary Neoplasms  (ISO)
Anophthalmia  (ISO)
anterior segment dysgenesis  (ISO)
aortic disease  (ISO)
Arteriovenous Fistula  (ISO)
atherosclerosis  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Carotid Atherosclerosis  (ISO)
cerebral infarction  (ISO)
chronic kidney disease  (ISO)
coloboma  (ISO)
colon adenoma  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Dyslipidemias  (ISO)
essential hypertension  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Eye Abnormalities  (ISO)
familial hypercholesterolemia  (ISO)
familial temporal lobe epilepsy 1  (ISO)
gallbladder cancer  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
Insulin Resistance  (ISO)
Jaundice  (ISO)
keratomalacia  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Metabolic Syndrome  (ISO)
microphthalmia  (ISO)
Microphthalmia/Coloboma 10  (ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
obesity  (ISO)
Pediatric Obesity  (ISO)
polycystic ovary syndrome  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prehypertension  (ISO)
proliferative diabetic retinopathy  (ISO)
psoriasis  (ISO)
Retinal Dystrophy, Iris Coloboma, and Comedogenic Acne Syndrome  (ISO)
severe pre-eclampsia  (ISO)
Spontaneous Abortions  (ISO)
Stable Angina  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
type 2 diabetes mellitus  (ISO)
Vision Disorders  (ISO)
Vitamin A Deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rbp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955507108,669 - 120,584 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955507112,342 - 120,050 (-)NCBIChiLan1.0ChiLan1.0
RBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381093,591,694 - 93,601,744 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1093,591,687 - 93,601,744 (-)EnsemblGRCh38hg38GRCh38
GRCh371095,351,451 - 95,361,501 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361095,341,583 - 95,350,983 (-)NCBINCBI36Build 36hg18NCBI36
Build 341095,341,583 - 95,350,983NCBI
Celera1089,092,718 - 89,102,118 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,979,353 - 88,988,753 (-)NCBIHuRef
CHM1_11095,634,147 - 95,643,547 (-)NCBICHM1_1
T2T-CHM13v2.01094,471,646 - 94,481,695 (-)NCBIT2T-CHM13v2.0
Rbp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,105,068 - 38,113,769 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,105,077 - 38,113,729 (-)EnsemblGRCm39 Ensembl
GRCm381938,116,620 - 38,125,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,116,629 - 38,125,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv371938,191,110 - 38,199,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361938,181,773 - 38,190,392 (-)NCBIMGSCv36mm8
Celera1938,908,311 - 38,919,212 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.75NCBI
Rbp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81245,306,349 - 245,313,551 (-)NCBIGRCr8
mRatBN7.21235,893,917 - 235,901,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,893,917 - 235,901,399 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,315,318 - 244,322,517 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01251,211,097 - 251,218,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,049,331 - 244,056,533 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,806,476 - 256,813,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,806,472 - 256,813,711 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01264,286,998 - 264,294,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,443,795 - 242,450,997 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,637,193 - 242,644,147 (-)NCBI
Celera1232,987,269 - 232,994,470 (-)NCBICelera
RH 3.4 Map11581.5RGD
Cytogenetic Map1q53NCBI
RBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28105,629,725 - 105,639,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110105,635,040 - 105,644,675 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01090,337,879 - 90,347,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11093,848,166 - 93,857,679 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1093,848,166 - 93,857,887 (-)Ensemblpanpan1.1panPan2
RBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,822,936 - 7,830,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,822,944 - 7,830,750 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,999,367 - 8,007,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0288,083,216 - 8,090,965 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl288,083,226 - 8,090,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,802,939 - 7,810,708 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,832,158 - 7,839,906 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0288,002,083 - 8,009,832 (-)NCBIUU_Cfam_GSD_1.0
Rbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721339,768,612 - 39,777,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366011,402,691 - 1,410,208 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366011,401,215 - 1,410,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14105,037,464 - 105,044,765 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114105,037,360 - 105,044,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214114,769,053 - 114,775,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1986,831,042 - 86,840,668 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl986,830,957 - 86,840,250 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604847,606,135 - 47,615,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247374,791,628 - 4,800,989 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247374,795,054 - 4,800,830 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000005297   ⟹   ENSCLAP00000005201
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955507108,669 - 120,584 (-)Ensembl
RefSeq Acc Id: XM_013506237   ⟹   XP_013361691
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955507112,342 - 120,050 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013361691 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000005201
  ENSCLAP00000005201.1
Reference Protein Sequences
RefSeq Acc Id: XP_013361691   ⟸   XM_013506237
- UniProtKB: A0A8C2UV09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000005201   ⟸   ENSCLAT00000005297
Protein Domains
Lipocalin/cytosolic fatty-acid binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003692 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005297 ENTREZGENE
  ENSCLAT00000005297.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin_ApoD UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/TrEMBL
  Retinol-bd/Purpurin UniProtKB/TrEMBL
NCBI Gene Rbp4 ENTREZGENE
PANTHER PTHR11873 UniProtKB/TrEMBL
  RETINOL-BINDING PROTEIN 4 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PIRSF Lipocalin_ApoD UniProtKB/TrEMBL
  RBP_purpurin UniProtKB/TrEMBL
PRINTS LIPOCALIN UniProtKB/TrEMBL
  RETINOLBNDNG UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/TrEMBL
UniProt A0A8C2UV09 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Rbp4  retinol binding protein 4    retinol binding protein 4, plasma  Symbol and/or name change 5135510 APPROVED