Gpx3 (glutathione peroxidase 3) - Rat Genome Database

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Gene: Gpx3 (glutathione peroxidase 3) Chinchilla lanigera
Analyze
Symbol: Gpx3
Name: glutathione peroxidase 3
RGD ID: 8713550
Description: ENCODES a protein that exhibits glutathione peroxidase activity (ortholog); identical protein binding (ortholog); mercury ion binding (ortholog); INVOLVED IN cellular oxidant detoxification (ortholog); hydrogen peroxide catabolic process (ortholog); response to corticosterone (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutathione peroxidase 3 (plasma)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,622,741 - 2,629,032 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,622,162 - 2,629,088 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
acute myocardial infarction  (ISO)
adenocarcinoma  (ISO)
aortic valve disease  (ISO)
atherosclerosis  (ISO)
Barrett's adenocarcinoma  (ISO)
Barrett's esophagus  (ISO)
Binge Drinking  (ISO)
brain ischemia  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (ISO)
Carotid Atherosclerosis  (ISO)
cerebral infarction  (ISO)
cerebral venous thrombosis  (ISO)
cerebrovascular disease  (ISO)
colon cancer  (ISO)
colorectal adenoma  (ISO)
colorectal carcinoma  (ISO)
congenital heart disease  (ISO)
coronary artery disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (ISO)
endometrial adenocarcinoma  (ISO)
endometriosis  (ISO)
esophageal cancer  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis 1  (ISO)
Fanconi syndrome  (ISO)
gallbladder carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
intracranial sinus thrombosis  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
lymphoplasmacytic lymphoma  (ISO)
male infertility  (ISO)
meningioma  (ISO)
Mercury Poisoning  (ISO)
Metabolic Syndrome  (ISO)
mild pre-eclampsia  (ISO)
multiple myeloma  (ISO)
Myocardial Reperfusion Injury  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
nephrotic syndrome  (ISO)
nephrotoxicity  (ISO)
neurodegenerative disease  (ISO)
obesity  (ISO)
Perinatal Asphyxia  (ISO)
polycystic ovary syndrome  (ISO)
Postoperative Atrial Fibrillation  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Primary Graft Dysfunction  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Radiation Injuries  (ISO)
rectum cancer  (ISO)
sciatic neuropathy  (ISO)
severe pre-eclampsia  (ISO)
spermatic cord torsion  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular Calcification  (ISO)
vitamin B12 deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gpx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,622,741 - 2,629,032 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,622,162 - 2,629,088 (-)NCBIChiLan1.0ChiLan1.0
GPX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,020,591 - 151,028,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,020,591 - 151,028,988 (+)EnsemblGRCh38hg38GRCh38
GRCh375150,400,152 - 150,408,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,380,192 - 150,388,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 345150,380,111 - 150,388,741NCBI
Celera5146,481,339 - 146,489,894 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,545,808 - 145,554,363 (+)NCBIHuRef
CHM1_15149,832,791 - 149,841,346 (+)NCBICHM1_1
T2T-CHM13v2.05151,557,070 - 151,565,467 (+)NCBIT2T-CHM13v2.0
Gpx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,793,680 - 54,801,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,793,279 - 54,801,203 (+)EnsemblGRCm39 Ensembl
GRCm381154,902,854 - 54,910,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,902,453 - 54,910,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,716,355 - 54,723,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,746,373 - 54,753,800 (+)NCBIMGSCv36mm8
Celera1159,492,255 - 59,499,807 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Gpx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,529,335 - 39,537,406 (+)NCBIGRCr8
mRatBN7.21039,028,624 - 39,036,695 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,028,570 - 39,037,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,717,089 - 43,725,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,207,165 - 43,215,235 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,710,877 - 38,718,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,247,436 - 40,255,423 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,247,436 - 40,255,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,019,704 - 40,027,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,311,094 - 40,319,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,324,744 - 40,333,004 (+)NCBI
Celera1038,366,821 - 38,374,734 (+)NCBICelera
Cytogenetic Map10q22NCBI
GPX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,252,293 - 146,260,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,391,889 - 144,400,394 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,447,939 - 146,456,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,450,426 - 152,458,994 (+)NCBIpanpan1.1PanPan1.1panPan2
GPX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,200,671 - 58,209,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,200,672 - 58,209,010 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,952,390 - 57,960,731 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,638,793 - 58,647,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,638,795 - 58,647,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,456,392 - 58,464,733 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,555,078 - 58,563,407 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,058,428 - 59,066,768 (-)NCBIUU_Cfam_GSD_1.0
Gpx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,903,260 - 116,911,461 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,906,113 - 3,913,498 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,904,787 - 3,914,223 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,980,475 - 71,989,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,980,467 - 71,989,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21678,282,309 - 78,290,916 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,576,950 - 53,585,321 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603424,129,632 - 24,138,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,957,999 - 40,962,993 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473340,957,895 - 40,963,469 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000018211   ⟹   ENSCLAP00000018033
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554082,622,741 - 2,629,032 (-)Ensembl
RefSeq Acc Id: XM_005376065   ⟹   XP_005376122
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554082,622,162 - 2,629,088 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005376122 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018033
  ENSCLAP00000018033.1
RefSeq Acc Id: XP_005376122   ⟸   XM_005376065
- UniProtKB: A0A8C2VS33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000018033   ⟸   ENSCLAT00000018211


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012373 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018211 ENTREZGENE
  ENSCLAT00000018211.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione_peroxidase UniProtKB/TrEMBL
  GPX_CS UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene Gpx3 ENTREZGENE
PANTHER GLUTATHIONE PEROXIDASE 3 UniProtKB/TrEMBL
  PTHR11592 UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/TrEMBL
PIRSF Glutathion_perox UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_2 UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A8C2VS33 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Gpx3  glutathione peroxidase 3    glutathione peroxidase 3 (plasma)  Symbol and/or name change 5135510 APPROVED