RGD Reference Report - Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome. - Rat Genome Database

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Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome.

Authors: Zhou, Yanyuan  Lan, Huan  Dong, Zhewen  Li, Wanying  Qian, Bo  Zeng, Zhen  He, Wen  Song, Jia-Le 
Citation: Zhou Y, etal., Oxid Med Cell Longev. 2022 May 26;2022:5558599. doi: 10.1155/2022/5558599. eCollection 2022.
RGD ID: 401827905
Pubmed: PMID:35663203   (View Abstract at PubMed)
PMCID: PMC9162838   (View Article at PubMed Central)
DOI: DOI:10.1155/2022/5558599   (Journal Full-text)

Polycystic ovary syndrome (PCOS) is a common endocrine-related cause of infertility in women and has an unknown etiology. Studies have shown that rhamnocitrin (Rha) exhibits positive effects on the reproductive system. This study investigated Rha's antifibrotic effects on PCOS rats and revealed its underlying mechanisms. Female SD rats were randomized into 4 groups (n = 8, each); the control group received tea oil by intraperitoneal injection and 1% w/v CMC by oral gavage; the PCOS group received letrozole (1 mg/kg); the PCOS+Rha group received letrozole and Rha (5 mg/kg); the PCOS+Met group received letrozole and Met (265 mg/kg) for 21 days. At the study end, Rha treatment restored letrozole-induced alterations in the relative ovarian weights, body weight, and relative weights of uterine and visceral adipose tissues. Histological observation showed that Rha ameliorates ovarian structure and fibrosis in PCOS. Administration of Rha reduced letrozole-induced metabolic dysfunction by ameliorating the levels of TC, TG, and HDL-C in the PCOS rats. Rha treatment also modulated the serum levels of sex hormones, which decreased T, E2, and LH and increased FSH in PCOS rats. In addition, Rha treatment modulated insulin resistance and increased gene expression of antioxidant enzymes (Cat, Sod2, Gpx3, Mgst1, Prdx3, Gsta4, Gsr, and Sod1) in the ovaries of the PCOS rats. Finally, Rha treatment appeared to increase the activity of PPAR-γ and inhibit the TGF-β1/Smad pathway in the ovaries of the PCOS rats. Our findings suggest that Rha significantly ameliorated metabolic disturbances and ovarian fibrosis in the PCOS rats. Rha perhaps is an effective compound for preventing ovarian fibrosis in the future.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GPX3Humanpolycystic ovary syndrome treatmentISOGpx3 (Rattus norvegicus) RGD 
Gpx3Ratpolycystic ovary syndrome treatmentIEP  RGD 
Gpx3Mousepolycystic ovary syndrome treatmentISOGpx3 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gpx3  (glutathione peroxidase 3)

Genes (Mus musculus)
Gpx3  (glutathione peroxidase 3)

Genes (Homo sapiens)
GPX3  (glutathione peroxidase 3)


Additional Information