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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:limb ischemia
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Accession:DOID:0050852 term browser browse the term
Definition:An ischemia that is characterized by low blood supply to tissues in the limb due to interruption in the arterial blood supply. (DO)


show annotations for term's descendants           Sort by:
limb ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:11877468 RGD:737810 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 ISO RGD PMID:26315408 RGD:14367880 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G CS citrate synthase ISO RGD PMID:571116 RGD:243049254 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391 		JBrowse link
G CSF2 colony stimulating factor 2 ISO protein:increased expression:plasma: RGD PMID:16648859 RGD:10449511 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CSF3 colony stimulating factor 3 treatment IDA RGD PMID:23294128 PMID:16224058 RGD:10400895, RGD:11039414 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 exacerbates
ameliorates		 ISO
IDA		 RGD PMID:20508179 PMID:35301145 PMID:22252294 RGD:155641249, RGD:155663375, RGD:155663358 NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073 		JBrowse link
G EPO erythropoietin treatment IDA RGD PMID:23294128 RGD:10400895 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G ETV2 ETS variant transcription factor 2 exacerbates
ameliorates		 ISO
IDA		 RGD PMID:26586661 PMID:28466428 PMID:32075417 PMID:28424975 PMID:28424975 RGD:11076207, RGD:192379484, RGD:192186227, RGD:156451664, RGD:156451664 NCBI chr19:35,641,745...35,644,871
Ensembl chr19:35,641,745...35,644,871 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 treatment ISO RGD PMID:25388665 RGD:11568031 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment ISO RGD PMID:26604244 RGD:13514042 NCBI chr11:67,266,473...67,286,556
Ensembl chr11:67,266,473...67,286,556 		JBrowse link
G HGF hepatocyte growth factor treatment IDA RGD PMID:15238569 RGD:8548639 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:skeletal muscle RGD PMID:17522350 RGD:1626332 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:12593860 RGD:1598394 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G ITGAM integrin subunit alpha M IEP protein:increased expression:monocyte (human) RGD PMID:20816321 RGD:329901827 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITGAV integrin subunit alpha V ISO RGD PMID:15750161 RGD:1582449 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901 		JBrowse link
G MIR126 microRNA 126 ameliorates ISO associated with type 1 diabetes mellitus; RGD PMID:29242072 PMID:35151721 RGD:401851035, RGD:401851044 NCBI chr 9:136,670,602...136,670,686
Ensembl chr 9:136,670,602...136,670,686 		JBrowse link
G MIR210 microRNA 210 severity ISO RGD PMID:31878120 RGD:155882482 NCBI chr11:568,089...568,198
Ensembl chr11:568,089...568,198 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO
IMP		 associated with Diabetes Mellitus, Experimental
human gene in rat model		 RGD PMID:19080171 PMID:28979692 PMID:12171788 RGD:7794710, RGD:13450931, RGD:7794776 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22369073 PMID:21940947 RGD:6767285, RGD:6906905 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PPBP pro-platelet basic protein IEP protein:increased expression:plasma RGD PMID:30638058 RGD:401794451 NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190 		JBrowse link
G PTGIS prostaglandin I2 synthase treatment IMP
ISO		 human gene in a mouse model
rat gene in human cells in a mouse model		 RGD PMID:12586736 PMID:19344900 PMID:14568901 RGD:401959585, RGD:401960096, RGD:401960079 NCBI chr20:49,503,874...49,568,137
Ensembl chr20:49,503,874...49,568,137 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 ISO protein:increased expression, increased activity:hindlimb muscle (mouse) RGD PMID:18451337 RGD:401965417 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241 		JBrowse link
G VEGFA vascular endothelial growth factor A treatment ISO RGD PMID:23562340 RGD:7421600 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
limb reperfusion injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPT glutamic--pyruvic transaminase treatment ISO RGD PMID:36495512 RGD:401717522 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 35756
    Pathological Conditions, Signs and Symptoms 21495
      Pathologic Processes 13190
        ischemia 1557
          limb ischemia 24
            limb reperfusion injury 1
Path 2
Term Annotations click to browse term
  disease 35756
    disease of anatomical entity 32495
      cardiovascular system disease 6078
        vascular disease 3863
          ischemia 1557
            limb ischemia 24
              limb reperfusion injury 1
paths to the root