RGD Reference Report - Plasma NAP-2 levels are associated with critical limb ischemia in peripheral arterial disease patients. - Rat Genome Database

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Plasma NAP-2 levels are associated with critical limb ischemia in peripheral arterial disease patients.

Authors: Wang, Xiufang  Li, Juyi  Gan, Liming  Liu, Qun 
Citation: Wang X, etal., Exp Biol Med (Maywood). 2019 Jan;244(1):22-27. doi: 10.1177/1535370218823684. Epub 2019 Jan 12.
RGD ID: 401794451
Pubmed: PMID:30638058   (View Abstract at PubMed)
PMCID: PMC6362532   (View Article at PubMed Central)
DOI: DOI:10.1177/1535370218823684   (Journal Full-text)

Critical limb ischemia (CLI) is a serious arterial obstruction, resulting in serious reduction of blood flow to the extremities. CLI is a symptomatic disorder and is frequently not diagnosed in time. This results in a high mortality and elevated risk of limb amputation. Serum or plasma biomarkers play important roles in disease prevention, diagnosis, and prognosis. Elevated plasma neutrophil-activating peptide-2 (NAP-2) was found independently associated with CLI, but not with T2DM. Plasma NAP-2 levels might be an early CLI diagnostic biomarker and might provide a novel target for CLI treatment.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PPBPHumanlimb ischemia  IEP protein:increased expression:plasmaRGD 
PpbpRatlimb ischemia  ISOPPBP (Homo sapiens)protein:increased expression:plasmaRGD 
PpbpMouselimb ischemia  ISOPPBP (Homo sapiens)protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ppbp  (pro-platelet basic protein)

Genes (Mus musculus)
Ppbp  (pro-platelet basic protein)

Genes (Homo sapiens)
PPBP  (pro-platelet basic protein)


Additional Information