The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA] 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA; 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased phosphorylation of MAPK8 protein 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of and affects the stability of NFKBIA protein]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]
CES1 protein affects the hydrolysis of Oseltamivir 7,8-dihydromethysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; [CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate; [hirsutine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [mitragynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [paynantheine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [Plant Extracts results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [speciogynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; desmethoxyyangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; dihydrokavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; kavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; methysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; yangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]
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