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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phytosphingosine
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Accession:CHEBI:46961 term browser browse the term
Definition:An amino alcohol that has formula 317.50720.
Synonyms:exact_synonym: (2S,3S,4R)-2-aminooctadecane-1,3,4-triol
 related_synonym: 4-D-Hydroxysphinganine;   4-R-hydroxyoctadecasphinganine;   Formula=C18H39NO3;   InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1;   InChIKey=AERBNCYCJBRYDG-KSZLIROESA-N;   SMILES=CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
 alt_id: CHEBI:26123;   CHEBI:31999
 xref: Beilstein:1725301;   CAS:554-62-1;   KEGG:C12144;   LIPID_MAPS_instance:LMSP01030001
 xref_mesh: MESH:C012491
 cyclic_relationship: is_conjugate_base_of CHEBI:64124


show annotations for term's descendants           Sort by:
phytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization
multiple interactions		 ISO phytosphingosine affects the localization of AIFM1 protein
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein]		 CTD PMID:15486061 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects localization
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]
phytosphingosine affects the localization of BAX protein
phytosphingosine results in increased expression of BAX protein		 CTD PMID:15486061 PMID:17237268 PMID:36334778 PMID:37956922 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO phytosphingosine results in increased expression of BCL2 protein CTD PMID:36334778 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; phytosphingosine results in increased expression of and results in increased cleavage of CASP3 protein; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]
phytosphingosine results in increased expression of CASP3 protein		 CTD PMID:17237268 PMID:36334778 PMID:37956922 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]
phytosphingosine results in increased expression of CASP9 protein		 CTD PMID:17237268 PMID:37956922 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO phytosphingosine results in decreased expression of CCNB1 protein CTD PMID:37956922 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO phytosphingosine results in decreased expression of CDK1 protein CTD PMID:37956922 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO phytosphingosine results in increased expression of CYCS protein CTD PMID:36334778 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein CTD PMID:17237268 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein] CTD PMID:17237268 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein CTD PMID:17237268 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
increases cleavage		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]
phytosphingosine results in increased activity of PARP1 protein
phytosphingosine results in increased cleavage of PARP1 protein		 CTD PMID:15486061 PMID:17237268 PMID:37956922 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pink1 PTEN induced kinase 1 decreases expression ISO phytosphingosine results in decreased expression of PINK1 protein CTD PMID:36334778 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO KRN 7000 results in increased expression of CXCL10 protein CTD PMID:15867097 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Il12b interleukin 12B increases expression ISO KRN 7000 results in increased expression of IL12B protein CTD PMID:15867097 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      application 19658
        NMR chemical shift reference compound 17961
          ammonia 17820
            organic amino compound 17820
              amino alcohol 1072
                phytosphingosine 15
                  1-O-(6-deoxy-6-benzamido-alpha-D-galactopyranosyl)-N-hexacosanoylphytosphingosine 0
                  1-O-\{6-deoxy-6-[N'-(1-naphthyl)ureido]-alpha-D-galactopyranosyl\}-N-hexacosanoylphytosphingosine 0
                  C-glycosylphytoceramide + 0
                  Ins-1-P-Cer(t18:0/2-OH-26:0) + 0
                  N-(2-hydroxyhexacosanoyl)phytosphingosine-1-phospho-(1D-myo-inositol) 0
                  N-acylphytosphingosine + 2
                  N-acylphytosphingosine 1-phosphate + 0
                  N-acylphytosphingosine-1-phosphocholine + 0
                  N-hexadecanoylphytosphingosine-1-phosphocholine 0
                  N-hexadecanoylphytosphingosine-1-phosphoethanolamine 0
                  beta-D-glucosyl-(1<->1')-N-acylphytosphingosine 0
                  inositol phosphomannosylinositol-1-phospho-N-acylphytosphingosine + 0
                  phytosphingosine 1-phosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      carboacyl group 17696
                                        univalent carboacyl group 17696
                                          carbamoyl group 17546
                                            carboxamide 17546
                                              ceramide 127
                                                cerebroside 25
                                                  galactosylceramide 25
                                                    beta-galactosylceramide 15
                                                      N-acyl-beta-D-galactosylphytosphingosine 15
                                                        phytosphingosine 15
                                                          1-O-(6-deoxy-6-benzamido-alpha-D-galactopyranosyl)-N-hexacosanoylphytosphingosine 0
                                                          1-O-\{6-deoxy-6-[N'-(1-naphthyl)ureido]-alpha-D-galactopyranosyl\}-N-hexacosanoylphytosphingosine 0
                                                          C-glycosylphytoceramide + 0
                                                          Ins-1-P-Cer(t18:0/2-OH-26:0) + 0
                                                          N-(2-hydroxyhexacosanoyl)phytosphingosine-1-phospho-(1D-myo-inositol) 0
                                                          N-acylphytosphingosine + 2
                                                          N-acylphytosphingosine 1-phosphate + 0
                                                          N-acylphytosphingosine-1-phosphocholine + 0
                                                          N-hexadecanoylphytosphingosine-1-phosphocholine 0
                                                          N-hexadecanoylphytosphingosine-1-phosphoethanolamine 0
                                                          beta-D-glucosyl-(1<->1')-N-acylphytosphingosine 0
                                                          inositol phosphomannosylinositol-1-phospho-N-acylphytosphingosine + 0
                                                          phytosphingosine 1-phosphate + 0
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