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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diethyl sulfate
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Accession:CHEBI:34699 term browser browse the term
Definition:The diethyl ester of sulfuric acid.
Synonyms:related_synonym: DES;   Diaethylsulfat;   Et2SO4;   Formula=C4H10O4S;   InChI=1S/C4H10O4S/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3;   InChIKey=DENRZWYUOJLTMF-UHFFFAOYSA-N;   SMILES=CCOS(=O)(=O)OCC;   diethyl sulphate;   diethyl tetraoxosulfate;   diethylsulfate;   ethyl sulfate;   sulfuric acid diethyl ester;   sulphuric acid diethyl ester
 xref: CAS:64-67-5;   CBA:310330;   CBA:374048;   CBA:593867;   Chemspider:5931;   HMDB:HMDB0251240;   KEGG:C14706
 xref_mesh: MESH:C011612
 xref: PMID:15323041;   PMID:17619463;   PMID:20566339;   PMID:21089860;   PMID:21852824;   PMID:23830811;   PMID:24681631;   PMID:24686557;   PMID:25484124;   PMID:26591512;   PMID:2797029;   PMID:2927429;   PMID:29397772;   PMID:29615826;   PMID:30417660;   PMID:3312952;   Wikipedia:Diethyl_sulfate


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diethyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO diethyl sulfate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO diethyl sulfate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO diethyl sulfate results in increased expression of BAX protein CTD PMID:23830811 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO diethyl sulfate results in decreased expression of BCL2 protein CTD PMID:23830811 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression		 ISO diethyl sulfate results in increased cleavage of CASP3 protein
diethyl sulfate results in increased expression of CASP3 protein modified form		 CTD PMID:23830811 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO diethyl sulfate affects the expression of CCNA2 protein CTD PMID:23887207 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO diethyl sulfate affects the expression of CCNB1 protein CTD PMID:23887207 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects phosphorylation ISO diethyl sulfate affects the phosphorylation of CDK2 protein CTD PMID:23887207 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 affects expression ISO diethyl sulfate affects the expression of CDK4 protein CTD PMID:23887207 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression
increases expression		 ISO diethyl sulfate results in decreased expression of CHEK1 protein modified form
diethyl sulfate results in increased expression of CHEK1 protein modified form		 CTD PMID:23830811 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression
increases expression		 ISO diethyl sulfate results in decreased expression of CHEK2 protein modified form
diethyl sulfate results in increased expression of CHEK2 protein modified form		 CTD PMID:23830811 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO diethyl sulfate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO diethyl sulfate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO diethyl sulfate results in increased expression of GCLC mRNA CTD PMID:20491607 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO diethyl sulfate results in increased expression of HMOX1 mRNA CTD PMID:20491607 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO diethyl sulfate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; diethyl sulfate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO diethyl sulfate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression		 ISO diethyl sulfate results in decreased expression of TP53 protein
diethyl sulfate results in increased expression of TP53 protein		 CTD PMID:23830811 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      biological role 19808
        aetiopathogenetic role 19188
          carcinogenic agent 18519
            diethyl sulfate 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      chalcogen 19538
                        oxygen atom 19513
                          oxygen molecular entity 19513
                            hydroxides 19325
                              oxoacid 18760
                                chalcogen oxoacid 13770
                                  sulfur oxoacid 13557
                                    sulfuric acid 8240
                                      sulfuric acid derivative 8240
                                        sulfates 8235
                                          organic sulfate 2274
                                            alkyl sulfate 23
                                              diethyl sulfate 18
paths to the root