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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:S-nitroso-L-cysteine
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Accession:CHEBI:138935 term browser browse the term
Definition:An L-cysteine derivative in which the sulfur atom carries a nitroso substituent. A cell-permeable low-molecular-weight nitrosothiol and nitric oxide donor.
Synonyms:related_synonym: CysNO;   Formula=C3H6N2O3S;   InChI=1S/C3H6N2O3S/c4-2(3(6)7)1-9-5-8/h2H,1,4H2,(H,6,7)/t2-/m0/s1;   InChIKey=XOWVFANEOZMPKG-REOHCLBHSA-N;   L-CysSNO;   NO-L-cysteine;   NO-cysteine;   Nitrosocysteine;   S-Nitrosocysteine;   SMILES=C([C@@H](N)CSN=O)(=O)O
 alt_id: CHEBI:45691
 xref: CAS:51209-75-7
 xref_mesh: MESH:C021315
 xref: PDBeChem:SNC;   PMID:22304688;   PMID:26444682;   PMID:26686469;   PMID:27064847;   PMID:27126574;   PMID:28081246;   PMID:28381519;   PMID:28440386;   PMID:28600633;   PMID:28764371;   Reaxys:3538115


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S-nitroso-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions ISO S-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein] CTD PMID:17482545 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 increases nitrosation ISO S-nitrosocysteine results in increased nitrosation of GRK2 protein CTD PMID:17482545 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP [S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] CTD PMID:16386761 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein]; S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:24451382 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      application 19653
        pharmaceutical 19494
          drug 19494
            hematologic agent 4955
              S-nitroso-L-cysteine 6
                S-nitroso-L-cysteine residue 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    main group molecular entity 19782
                      s-block molecular entity 19620
                        hydrogen molecular entity 19607
                          hydrides 19113
                            inorganic hydride 18117
                              pnictogen hydride 18106
                                nitrogen hydride 18013
                                  azane 17821
                                    ammonia 17820
                                      organic amino compound 17820
                                        amino acid 15946
                                          alpha-amino acid 13860
                                            L-alpha-amino acid 12849
                                              serine family amino acid 5538
                                                L-cysteine 3404
                                                  L-cysteine derivative 3396
                                                    S-nitroso-L-cysteine 6
                                                      S-nitroso-L-cysteine residue 0
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