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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
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Accession:CHEBI:94995 term browser browse the term
Definition:A quinuclidine that has formula C9H15NO3.
Synonyms:related_synonym: Formula=C9H15NO3;   InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2;   InChIKey=RFBVBRVVOPAAFS-UHFFFAOYSA-N;   SMILES=C1CN2CCC1C(=O)C2(CO)CO
 xref: LINCS:LSM-6220
 xref_mesh: MESH:C451219


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2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX protein
Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]		 CTD PMID:21109480 PMID:21647879 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA] CTD PMID:21109480 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in decreased expression of BCL2L1 protein CTD PMID:21109480 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:21109480 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A protein
Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]; Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]		 CTD PMID:21109480 PMID:21647879 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of MDM2 CTD PMID:21647879 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one co-treated with Cisplatin] results in increased expression of PMAIP1 mRNA CTD PMID:21109480 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases activity		 ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [TP53 protein mutant form binds to TP73 protein]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [Cisplatin results in increased localization of TP53 protein mutant form]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [TP53 protein results in increased susceptibility to resveratrol]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of and results in increased localization of and results in increased activity of TP53 protein mutant form; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]
2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased activity of TP53 protein; TP53 protein mutant form results in increased activity of 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one		 CTD PMID:15860260 PMID:21109480 PMID:21647879 PMID:23152798 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [TP53 protein mutant form binds to TP73 protein] CTD PMID:21647879 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [Progestins results in increased expression of VEGFA mRNA] CTD PMID:15860260 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      group 19798
        inorganic group 19393
          oxo group 18898
            organic oxo compound 18898
              carbonyl compound 18898
                ketone 17187
                  cyclic ketone 15703
                    2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  organic heteropolycyclic compound 18301
                                    organic heterobicyclic compound 17235
                                      quinuclidines 68
                                        2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one 10
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