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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
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Accession:CHEBI:94355 term browser browse the term
Definition:An imidazopyridine that has formula C14H13N3.
Synonyms:related_synonym: CGS 16949A;   Formula=C14H13N3;   InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2;   InChIKey=CLPFFLWZZBQMAO-UHFFFAOYSA-N;   SMILES=C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N;   fadrozole HCl;   fadrozole hydrochloride;   fadrozole monohydrochloride
 xref: CAS:102676-47-1;   Drug_Central:1126;   LINCS:LSM-5015
 xref_mesh: MESH:D017316


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4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression ISO Fadrozole results in decreased expression of ACE protein CTD PMID:18586661 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression ISO Fadrozole results in increased expression of ACE2 protein CTD PMID:18586661 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Fadrozole results in decreased expression of AGTR1 protein CTD PMID:18586661 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression ISO Fadrozole results in increased expression of AGTR2 protein CTD PMID:18586661 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases activity ISO Fadrozole results in decreased activity of CYP11B2 protein CTD PMID:15743198 PMID:15771425 PMID:15985365 PMID:21341743 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Fadrozole results in decreased activity of CYP17A1 protein CTD PMID:15743198 PMID:15771425 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
increases activity
multiple interactions		 ISO Fadrozole results in decreased activity of CYP19A1 protein
Fadrozole results in increased activity of CYP19A1 protein
Genistein inhibits the reaction [Fadrozole results in increased activity of CYP19A1 protein]		 CTD PMID:15743198 PMID:15771425 PMID:21341743 PMID:21854827 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases metabolic processing
affects metabolic processing		 ISO CYP2A6 protein results in increased metabolism of Fadrozole
CYP2A6 protein affects the metabolism of Fadrozole		 CTD PMID:12464242 PMID:12487152 PMID:15980104 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity ISO Fadrozole results in decreased activity of CYP51A1 protein CTD PMID:16989930 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Fadrozole binds to and results in decreased activity of ESR1 protein CTD PMID:33049310 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Fadrozole binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO [Dexamethasone co-treated with Fadrozole] inhibits the reaction [Testosterone results in increased expression of TFF1 mRNA]; Fadrozole inhibits the reaction [bisphenol A results in increased expression of TFF1 mRNA]; Fadrozole inhibits the reaction [Testosterone results in increased expression of TFF1 mRNA] CTD PMID:15525692 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    chemical entity 22181
      atom 22174
        nonmetal atom 22059
          nitrogen atom 20007
            nitrogen molecular entity 20007
              organonitrogen compound 19814
                organonitrogen heterocyclic compound 19070
                  imidazopyridine 707
                    4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      p-block molecular entity 22108
                        carbon group molecular entity 21909
                          organic molecular entity 21835
                            organic molecule 21652
                              organic cyclic compound 21261
                                organic heterocyclic compound 20329
                                  organic heteropolycyclic compound 19619
                                    organic heterobicyclic compound 18182
                                      imidazopyridine 707
                                        4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile 12
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