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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfinpyrazone
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Accession:CHEBI:9342 term browser browse the term
Definition:A pyrazolidine that has formula C23H20N2O3S.
Synonyms:exact_synonym: 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione
 related_synonym: 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine;   1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione;   4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione;   Anturane (TN);   Formula=C23H20N2O3S;   InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2;   InChIKey=MBGGBVCUIVRRBF-UHFFFAOYSA-N;   SMILES=O=C1C(CCS(=O)c2ccccc2)C(=O)N(N1c1ccccc1)c1ccccc1;   Sulfoxyphenylpyrazolidine
 xref: Beilstein:713597;   CAS:57-96-5;   DrugBank:DB01138;   Drug_Central:2528;   KEGG:C07317;   KEGG:D00449;   LINCS:LSM-1491
 xref_mesh: MESH:D013442
 xref: Wikipedia:Sulfinpyrazone


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sulfinpyrazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Sulfinpyrazone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Sulfinpyrazone results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions		 ISO
EXP		 Sulfinpyrazone results in decreased activity of ABCC1 protein
[Sulfinpyrazone results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine		 CTD PMID:12893836 PMID:15044619 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO Sulfinpyrazone results in decreased activity of ABCC2 protein CTD PMID:14569069 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Sulfinpyrazone results in increased expression of CYP2B6 protein CTD PMID:14977870 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Sulfinpyrazone results in decreased activity of CYP2C8 protein CTD PMID:12464242
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases activity		 ISO Sulfinpyrazone results in increased expression of CYP3A4 mRNA
Sulfinpyrazone results in increased activity of CYP3A4 protein		 CTD PMID:9512926 PMID:10219967 PMID:12065438 PMID:16837568 PMID:17954527 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO Sulfinpyrazone inhibits the reaction [GSTM1 protein results in decreased susceptibility to Vincristine] CTD PMID:15044619 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Sulfinpyrazone inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide] CTD PMID:15999103 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO Sulfinpyrazone binds to and results in increased activity of NR1I2 protein
Sulfinpyrazone results in increased activity of NR1I2 protein		 CTD PMID:12065438 PMID:14977870 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
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  CHEBI ontology 19844
    role 19820
      application 19663
        pharmaceutical 19504
          drug 19504
            renal agent 422
              uricosuric drug 407
                sulfinpyrazone 10
Path 2
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  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                organic heterocyclic compound 18870
                                  organic heteromonocyclic compound 17796
                                    diazolidine 1018
                                      pyrazolidines 29
                                        sulfinpyrazone 10
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