CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 1-(3-(trifluoromethyl)phenyl)piperazine
Accession: CHEBI:83536
browse the term
Definition: A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.
Synonyms: related_synonym: 1-(m-trifluoromethylphenyl)piperazine; 3-trifluoromethylphenylpiperazine; Formula=C11H13F3N2; InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2; InChIKey=KKIMDKMETPPURN-UHFFFAOYSA-N; N-(alpha,alpha,alpha-trifluoro-3-tolyl)piperazine; SMILES=C1=C(C(F)(F)F)C=CC=C1N2CCNCC2; TFMPP
xref: CAS:15532-75-9; LINCS:LSM-24939
xref_mesh: MESH:C018406
xref: PMID:23890650; PMID:24547667; PMID:24810679; PMID:24968061; Reaxys:614217; Wikipedia:Trifluoromethylphenylpiperazine
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Acat2
acetyl-CoA acetyltransferase 2
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of ACAT2 mRNA
CTD
PMID:26821219
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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Bhmt
betaine-homocysteine S-methyltransferase
decreases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in decreased expression of BHMT mRNA
CTD
PMID:26821219
NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
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Cyp51
cytochrome P450, family 51
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of CYP51 mRNA
CTD
PMID:26821219
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in decreased expression of CYP8B1 mRNA
CTD
PMID:26821219
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Esr1
estrogen receptor 1
multiple interactions
ISO
1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [Estradiol binds to ESR1 protein]
CTD
PMID:23026265
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Fads1
fatty acid desaturase 1
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of FADS1 mRNA
CTD
PMID:26821219
NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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Fasn
fatty acid synthase
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of FASN mRNA
CTD
PMID:26821219
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fdft1
farnesyl diphosphate farnesyl transferase 1
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDFT1 mRNA
CTD
PMID:26821219
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Fdps
farnesyl diphosphate synthase
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDPS mRNA
CTD
PMID:26821219
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:26344803
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:26344803
NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
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Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:26344803
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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Gpnmb
glycoprotein nmb
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of GPNMB mRNA
CTD
PMID:26821219
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCR mRNA
CTD
PMID:26821219
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCS1 mRNA
CTD
PMID:26821219
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of IDI1 mRNA
CTD
PMID:26821219
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Msmo1
methylsterol monooxygenase 1
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of MSMO1 mRNA
CTD
PMID:26821219
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Pcsk9
proprotein convertase subtilisin/kexin type 9
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of PCSK9 mRNA
CTD
PMID:26821219
NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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Pgr
progesterone receptor
increases expression
ISO
1-(3-trifluoromethylphenyl)piperazine results in increased expression of PGR mRNA
CTD
PMID:23026265
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Rragd
Ras-related GTP binding D
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of RRAGD mRNA
CTD
PMID:26821219
NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
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Sqle
squalene epoxidase
increases expression
EXP
1-(3-trifluoromethylphenyl)piperazine results in increased expression of SQLE mRNA
CTD
PMID:26821219
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Tff1
trefoil factor 1
increases expression
ISO
1-(3-trifluoromethylphenyl)piperazine results in increased expression of TFF1 mRNA
CTD
PMID:23026265
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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