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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-closantel
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Accession:CHEBI:77057 term browser browse the term
Definition:An N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide that has S configuration.
Synonyms:exact_synonym: N-{5-chloro-4-[(S)-(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide
 related_synonym: Formula=C22H14Cl2I2N2O2;   InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)/t17-/m0/s1;   InChIKey=JMPFSEBWVLAJKM-KRWDZBQOSA-N;   SMILES=Cc1cc([C@@H](C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O


show annotations for term's descendants           Sort by:
closantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions		 ISO ABCB1A protein results in decreased susceptibility to closantel
closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]		 CTD PMID:20513441 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP closantel results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Slc25a31 solute carrier family 25 member 31 decreases activity ISO closantel results in decreased activity of SLC25A31 protein CTD PMID:26746582 NCBI chr 2:123,695,387...123,711,275
Ensembl chr 2:123,695,408...123,710,795 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases activity ISO closantel results in decreased activity of SLC25A4 protein CTD PMID:26746582 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases activity ISO closantel results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
G Slc25a6 solute carrier family 25 member 6 decreases activity ISO closantel results in decreased activity of SLC25A6 protein CTD PMID:26746582 NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199 		JBrowse link
G Thra thyroid hormone receptor alpha increases activity EXP closantel results in increased activity of THRA protein CTD PMID:22015988 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta increases activity EXP closantel results in increased activity of THRB protein CTD PMID:22015988 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        pseudohalo group 4566
          cyano group 4566
            nitrile 4566
              N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide 8
                (S)-closantel 8
                  closantel 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide 8
                                                  (S)-closantel 8
                                                    closantel 8
paths to the root