CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: closantel
Accession: CHEBI:77053
browse the term
Definition: A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections.
Synonyms: exact_synonym: rac-N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide
related_synonym: 5'-chloro-alpha(4)-(p-chlorophenyl)-alpha(4)-cyano-3,5-diiodo-2',4'-salicyloxylidide; Flukiver; R 31,520; R 31520; Seponver; closantelum
xref: CAS:57808-65-8; KEGG:D03567
xref_mesh: MESH:C023342
xref: PMID:21247019; PMID:22916226; PMID:23992251; PMID:3330516; PMID:4054009; PMID:7119989; PMID:7571353; PMID:9138034; Patent:BE839481; Patent:US4005218; Reaxys:6249214
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases response to substance multiple interactions
ISO
ABCB1A protein results in decreased susceptibility to closantel closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
CTD
PMID:20513441
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Bcl3
BCL3, transcription coactivator
increases expression
EXP
closantel results in increased expression of BCL3 mRNA
CTD
PMID:22015988
NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
G
Slc25a31
solute carrier family 25 member 31
decreases activity
ISO
closantel results in decreased activity of SLC25A31 protein
CTD
PMID:26746582
NCBI chr 2:123,695,387...123,711,275
Ensembl chr 2:123,695,408...123,710,795
G
Slc25a4
solute carrier family 25 member 4
decreases activity
ISO
closantel results in decreased activity of SLC25A4 protein
CTD
PMID:26746582
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
G
Slc25a5
solute carrier family 25 member 5
decreases activity
ISO
closantel results in decreased activity of SLC25A5 protein
CTD
PMID:26746582
NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967
G
Slc25a6
solute carrier family 25 member 6
decreases activity
ISO
closantel results in decreased activity of SLC25A6 protein
CTD
PMID:26746582
NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199
G
Thra
thyroid hormone receptor alpha
increases activity
EXP
closantel results in increased activity of THRA protein
CTD
PMID:22015988
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Thrb
thyroid hormone receptor beta
increases activity
EXP
closantel results in increased activity of THRB protein
CTD
PMID:22015988
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all