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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nigericin
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Accession:CHEBI:7569 term browser browse the term
Definition:A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.
Synonyms:exact_synonym: (2R)-2-[(2R,3S,6R)-6-{[(2S,4R,5R,7R,9R,10R)-2-{(2S,2'R,3'S,5R,5'R)-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoic acid
 related_synonym: Azalomycin M;   Formula=C40H68O11;   Helixin C;   InChI=1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34/h21-35,41,44H,11-20H2,1-10H3,(H,42,43)/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+/m0/s1;   InChIKey=DANUORFCFTYTSZ-SJSJOXFOSA-N;   Polyetherin A;   SMILES=[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C(O)=O)C[C@@H]1C[C@@H](OC)[C@@H](C)[C@]2(O1)O[C@@](C)(C[C@H]2C)[C@@]1([H])CC[C@](C)(O1)[C@]1([H])O[C@]([H])(C[C@@H]1C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C
 alt_id: CHEBI:530451
 xref: Beilstein:74670;   CAS:28380-24-7;   KEGG:C11609;   KNApSAcK:C00018750
 xref_mesh: MESH:D009550
 xref: PMID:10341035;   PMID:10516103;   PMID:10996433;   PMID:15595852;   PMID:17618633;   PMID:20678563;   PMID:20709811;   PMID:20951746;   PMID:21257734;   PMID:22327078;   PMID:22493436;   PMID:7592045;   PMID:7638257;   PMID:7829226;   PMID:8010949;   PMID:8076364;   PMID:8717427;   PMID:8895841;   PMID:8913333;   PMID:9018148;   PMID:9178132;   PMID:9770325;   Patent:US3555150;   Reaxys:74670;   VSDB:2572;   Wikipedia:Nigericin



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nigericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 multiple interactions ISO Nigericin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Nigericin inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid] CTD PMID:28798983 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Casp1 caspase 1 multiple interactions
increases cleavage
ISO
EXP
[Nigericin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP1 protein; CASP1 protein affects the reaction [Nigericin results in increased secretion of IL1B protein]
Nigericin inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of CASP1 protein]]
Nigericin results in increased cleavage of CASP1 protein
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of CASP1 protein; [Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of CASP1 protein; Arsenic Trioxide inhibits the reaction [Nigericin results in increased cleavage of CASP1 protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of CASP1 protein]; sodium arsenite inhibits the reaction [Nigericin results in increased cleavage of CASP1 protein]
CTD PMID:18403674 PMID:23430110 PMID:24337744 PMID:36002070 PMID:36577999 More... NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions ISO Nigericin promotes the reaction [[DPP7 protein results in increased cleavage of Dipeptides] which results in increased abundance of 4-nitroaniline] CTD PMID:16725115 NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO
EXP
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of GSDMD protein]
Nigericin inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of GSDMD protein]]
CTD PMID:36002070 PMID:36577999 PMID:36898572 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases cleavage
ISO [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Nigericin] results in increased expression of IL1B protein; [Lipopolysaccharides co-treated with Nigericin] results in increased secretion of IL1B protein; Arsenic Trioxide inhibits the reaction [Nigericin results in increased cleavage of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased secretion of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased secretion of IL1B protein]; Okadaic Acid inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased expression of IL1B protein]; sodium arsenite inhibits the reaction [Nigericin results in increased cleavage of IL1B protein]
Nigericin results in increased secretion of IL1B protein
[Nigericin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1B protein; CASP1 protein affects the reaction [Nigericin results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [Nigericin results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Nigericin results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [Nigericin results in increased secretion of IL1B protein]
CTD PMID:18403674 PMID:19130485 PMID:23430110 PMID:24337744 PMID:29642561 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
NLRP3 protein affects the reaction [Nigericin results in increased secretion of IL1B protein]
Nigericin inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]]
CTD PMID:18403674 PMID:36898572 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nnat neuronatin decreases response to substance EXP NNAT protein results in decreased susceptibility to Nigericin CTD PMID:12101027 NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO
EXP
PYCARD protein affects the reaction [Nigericin results in increased secretion of IL1B protein]
Nigericin inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of PYCARD protein]]
CTD PMID:18403674 PMID:36898572 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Nigericin results in decreased expression of STAR protein CTD PMID:16469751 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Lipopolysaccharides co-treated with Nigericin] results in increased expression of TNF protein CTD PMID:23430110 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          nigericin 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  ether 17284
                                    cyclic ether 11758
                                      polycyclic ether 1422
                                        nigericin 10
paths to the root