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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:o-toluidine
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Accession:CHEBI:66892 term browser browse the term
Definition:An aminotoluene in which the amino substituent is ortho to the methyl group.
Synonyms:exact_synonym: 2-methylaniline
 related_synonym: 1-Amino-2-methylbenzene;   1-Methyl-2-aminobenzene;   2-Aminotoluene;   2-Methylbenzamine;   2-Methylbenzenamine;   2-Toluidine;   Formula=C7H9N;   InChI=1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3;   InChIKey=RNVCVTLRINQCPJ-UHFFFAOYSA-N;   SMILES=Cc1ccccc1N;   o-Aminotoluene;   o-Methylaniline;   o-Methylbenzenamine;   o-Tolylamine
 xref: CAS:95-53-4;   HMDB:HMDB0041965;   KEGG:C14403
 xref_mesh: MESH:C023622
 xref: PMID:21117897;   PMID:21320752;   PMID:21701861;   PMID:22004833;   PMID:22574454;   PMID:22708702;   PMID:22799188;   Reaxys:741981


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o-toluidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression ISO 2-toluidine results in increased expression of CYP2C29 mRNA CTD PMID:36870411 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO 2-toluidine results in increased expression of CYP3A4 mRNA; 2-toluidine results in increased expression of CYP3A4 protein CTD PMID:36870411 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-toluidine results in increased expression of H2AX protein CTD PMID:35279910 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine CTD PMID:20199096 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        aetiopathogenetic role 19166
          carcinogenic agent 18496
            o-toluidine 4
              5-nitro-o-toluidine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        aromatic amine 15400
                                          anilines 14398
                                            substituted aniline 14039
                                              aminotoluene 598
                                                o-toluidine 4
                                                  5-nitro-o-toluidine 0
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