CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: erythrosin B
Accession: CHEBI:61000
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Definition: An organic sodium salt that is the disodium salt of 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-8a,10a-dihydroxanthen-9-yl)benzoic acid.
Synonyms: exact_synonym: disodium 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-8a,10a-dihydro-3H-xanthen-9-yl)benzoate
related_synonym: 1427 Red; 1671 Red; 2',4',5',7'-Tetraiodofluoroescein disodium salt; 2,4,5,7-Tetraiodofluorescein disodium salt; 3',6-Dihydroxy-2',4',5',7'-tetraiodospiro(isobenzofuran-1(3H),9'(9H)xanthen)-one disodium salt; Acid red 51; Aizen Food Red 3; Aizen erythrosine; C.I. 45430; Erythrosin; Erythrosin B sodium salt; Erythrosin BS; Erythrosine; Erythrosine sodium (close form); FD&C Red No. 3; Food Color Red 3; Formula=C20H6I4Na2O5; InChI=1S/C20H8I4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2; InChIKey=IINNWAYUJNWZRM-UHFFFAOYSA-L; SMILES=[Na+].[Na+].[O-]C(=O)c1ccccc1-c1c2cc(I)c([O-])c(I)c2oc2c(I)c(=O)c(I)cc12
xref: CAS:16423-68-0
xref_mesh: MESH:D004923
xref: PMID:15206583; PMID:25308634; Reaxys:3583865
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Abcb1a
ATP binding cassette subfamily B member 1A
decreases activity
ISO
Erythrosine results in decreased activity of ABCB1 protein
CTD
PMID:20041016
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Casp9
caspase 9
multiple interactions
EXP
[Tartrazine co-treated with Erythrosine] affects the expression of CASP9 mRNA
CTD
PMID:32981412
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccnd1
cyclin D1
increases expression
ISO
Erythrosine results in increased expression of CCND1 protein
CTD
PMID:8927716
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdk2
cyclin dependent kinase 2
increases activity
ISO
Erythrosine results in increased activity of CDK2 protein
CTD
PMID:8927716 PMID:9168006
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
EXP
Erythrosine results in decreased activity of CYP19A1 protein
CTD
PMID:18310892
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
Erythrosine results in decreased activity of CYP3A4 protein
CTD
PMID:20041016
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
Erythrosine results in increased expression of FOSL1 protein
CTD
PMID:20025956
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Erythrosine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
EXP
[Tartrazine co-treated with Erythrosine] affects the expression of HAVCR1 mRNA
CTD
PMID:32981412
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Hpgds
hematopoietic prostaglandin D synthase
decreases activity
ISO
Erythrosine results in decreased activity of HPGDS protein
CTD
PMID:25603235
NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
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Iyd
iodotyrosine deiodinase
decreases activity
ISO
Erythrosine results in decreased activity of IYD protein
CTD
PMID:24012475
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Erythrosine results in increased expression of JUN protein
CTD
PMID:20025956
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Orm1
orosomucoid 1
increases expression
ISO
Erythrosine results in increased expression of ORM1 protein
CTD
PMID:20025956
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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Phex
phosphate regulating endopeptidase X-linked
increases expression
ISO
Erythrosine results in increased expression of PHEX protein
CTD
PMID:20025956
NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469
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Tnf
tumor necrosis factor
multiple interactions
EXP
[Tartrazine co-treated with Erythrosine] results in increased expression of TNF mRNA
CTD
PMID:32981412
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
increases activity
ISO
Erythrosine results in increased activity of TP53 protein
CTD
PMID:9168006
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trh
thyrotropin releasing hormone
multiple interactions
EXP
Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein]
CTD
PMID:2160137
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Tshb
thyroid stimulating hormone subunit beta
multiple interactions
EXP
Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein]
CTD
PMID:2160137
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
decreases activity
ISO
Erythrosine results in decreased activity of UGT1A6 protein
CTD
PMID:20041016
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
decreases activity
ISO
Erythrosine results in decreased activity of UGT2B7 protein
CTD
PMID:20041016
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
Erythrosine results in increased expression of VEGFA protein
CTD
PMID:20025956
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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