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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fenoprofen
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Accession:CHEBI:5004 term browser browse the term
Definition:A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Synonyms:exact_synonym: 2-(3-phenoxyphenyl)propanoic acid
 related_synonym: (+-)-m-phenoxyhydratropic acid;   2-(3-phenoxyphenyl)propionic acid;   2-(m-phenoxyphenyl)propionic acid;   Formula=C15H14O3;   InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17);   InChIKey=RDJGLLICXDHJDY-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1cccc(Oc2ccccc2)c1;   alpha-(m-phenoxyphenyl)propionic acid;   alpha-methyl-3-phenoxybenzeneacetic acid;   fenoprofene;   fenoprofeno;   fenoprofenum
 alt_id: CHEBI:355534
 xref: CAS:31879-05-7;   DrugBank:DB00573;   Drug_Central:1154;   KEGG:C06997;   KEGG:D02350
 xref_mesh: MESH:D005279
 xref: PMID:21328296;   PMID:21342694;   PMID:25554116;   PMID:28166217;   PMID:30168706;   PMID:4616811;   Patent:US3600437;   Reaxys:2118687;   Wikipedia:_Fenoprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:60566


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fenoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases metabolic processing ISO ACSL1 protein results in increased metabolism of Fenoprofen CTD PMID:10725307 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 increases metabolic processing ISO ACSL6 protein results in increased metabolism of Fenoprofen CTD PMID:10725307 NCBI chr11:54,194,580...54,255,582
Ensembl chr11:54,194,624...54,255,582 		JBrowse link
G Alb albumin multiple interactions
affects binding		 ISO Fenoprofen inhibits the reaction [Valproic Acid binds to ALB protein]; Ibuprofen inhibits the reaction [Fenoprofen binds to ALB protein]; Palmitic Acid inhibits the reaction [Fenoprofen binds to ALB protein] CTD PMID:62049 PMID:8946661 PMID:9353694 PMID:9470966 PMID:19596536 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Fenoprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr11:84,711,547...84,719,880
Ensembl chr11:84,711,682...84,719,820 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 affects expression ISO Fenoprofen affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2-Pa histocompatibility 2, P region alpha locus affects expression ISO Fenoprofen affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr17:34,303,587...34,304,826
Ensembl chr17:34,303,575...34,304,797 		JBrowse link
G Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) multiple interactions ISO [Fenoprofen co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) increases expression ISO Fenoprofen results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Fenoprofen binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO Fenoprofen binds to and results in increased activity of PPARG protein CTD PMID:9013583 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgr1 prostaglandin reductase 1 affects activity ISO Fenoprofen affects the activity of PTGR1 protein CTD PMID:25619643 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fenoprofen inhibits the reaction [rolafagrel results in decreased expression of TGFB1 mRNA] CTD PMID:8877289 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Fenoprofen co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of Fenoprofen CTD PMID:15117964 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Fenoprofen CTD PMID:15117964 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 increases glucuronidation
multiple interactions		 ISO UGT2B7 protein alternative form results in increased glucuronidation of Fenoprofen; UGT2B7 protein results in increased glucuronidation of Fenoprofen
Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]		 CTD PMID:8423545 PMID:8517101 PMID:19740398 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    role 22195
      application 21776
        anti-inflammatory agent 17353
          anti-inflammatory drug 15222
            non-steroidal anti-inflammatory drug 14432
              fenoprofen 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            heteroorganic entity 21517
                              organochalcogen compound 21005
                                organooxygen compound 20846
                                  carbon oxoacid 19634
                                    carboxylic acid 19630
                                      monocarboxylic acid 19004
                                        fenoprofen 16
paths to the root