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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quinoxalin-2-ol
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Accession:CHEBI:38890 term browser browse the term
Definition:A hydroxyquinoxaline that consists of quinoxaline having a single hydroxy substituent located at position 2.
Synonyms:related_synonym: 2-Hydroxyquinoxaline;   2-quinoxinol;   Formula=C8H6N2O;   InChI=1S/C8H6N2O/c11-8-5-9-6-3-1-2-4-7(6)10-8/h1-5H,(H,10,11);   InChIKey=FFRYUAVNPBUEIC-UHFFFAOYSA-N;   Quinoxalin-2-one;   SMILES=Oc1cnc2ccccc2n1
 xref: Beilstein:606883;   CAS:1196-57-2;   PMID:15606981;   PMID:16406213;   PMID:17295279;   PMID:17701694;   Reaxys:606883


show annotations for term's descendants           Sort by:
quinalphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions		 EXP
ISO		 quinalphos results in decreased activity of ACHE protein
Arsenic promotes the reaction [quinalphos results in decreased activity of ACHE protein]; quinalphos promotes the reaction [Arsenic results in decreased activity of ACHE protein]
quinalphos metabolite results in decreased activity of ACHE protein; quinalphos results in decreased activity of ACHE protein		 CTD PMID:32270456 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO quinalphos binds to and results in increased activity of AHR protein CTD PMID:18835618 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alb albumin multiple interactions EXP [Arsenic co-treated with quinalphos] results in decreased expression of ALB protein CTD PMID:32270456 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [quinalphos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions		 ISO quinalphos results in decreased activity of BCHE protein
pralidoxime inhibits the reaction [quinalphos results in decreased activity of BCHE protein]		 CTD PMID:24052565 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO
EXP		 Plant Extracts inhibits the reaction [quinalphos results in decreased activity of CAT protein]
[Arsenic co-treated with quinalphos] results in decreased activity of CAT protein		 CTD PMID:24581381 PMID:32270456 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO quinalphos results in increased expression of CYP19A1 mRNA CTD PMID:34014595 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression
multiple interactions		 ISO quinalphos results in decreased expression of CYP26B1 mRNA
Plant Extracts inhibits the reaction [quinalphos results in decreased expression of CYP26B1 mRNA]		 CTD PMID:24581381 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO quinalphos results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO quinalphos results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions
affects activity		 EXP [Monocrotophos co-treated with quinalphos] affects the activity of G6PD protein
quinalphos affects the activity of G6PD protein		 CTD PMID:24248738 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
affects activity
decreases activity		 EXP [Arsenic co-treated with quinalphos] results in decreased activity of GSR protein; [Monocrotophos co-treated with quinalphos] affects the activity of GSR protein
quinalphos affects the activity of GSR protein
quinalphos results in decreased activity of GSR protein		 CTD PMID:24248738 PMID:32270456 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 multiple interactions
decreases expression		 ISO Plant Extracts inhibits the reaction [quinalphos results in decreased expression of HSD3B3 mRNA] CTD PMID:24581381 NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO quinalphos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression		 ISO Plant Extracts inhibits the reaction [quinalphos results in decreased expression of STAR mRNA]; Plant Extracts inhibits the reaction [quinalphos results in decreased expression of STAR protein]
quinalphos results in decreased expression of STAR mRNA; quinalphos results in decreased expression of STAR protein		 CTD PMID:24581381 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO quinalphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            quinoxalin-2-ol 16
              quinalphos 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterobicyclic compound 17216
                                      mancude organic heterobicyclic parent 8316
                                        naphthyridine 2290
                                          quinoxaline 398
                                            quinoxaline derivative 398
                                              hydroxyquinoxaline 16
                                                quinoxalin-2-ol 16
                                                  quinalphos 16
paths to the root