CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: prothiofos
Accession: CHEBI:38873
browse the term
Definition: An organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid.
Synonyms: exact_synonym: O-(2,4-dichlorophenyl) O-ethyl S-propyl phosphorodithionate
related_synonym: Dichlorpropaphos; Formula=C11H15Cl2O2PS2; InChI=1S/C11H15Cl2O2PS2/c1-3-7-18-16(17,14-4-2)15-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3; InChIKey=FITIWKDOCAUBQD-UHFFFAOYSA-N; O-(2,4-dichlorophenyl) O-ethyl S-propyl dithiophosphate; Prothiophos; SMILES=CCCSP(=S)(OCC)Oc1ccc(Cl)cc1Cl
xref: Beilstein:1998314; CAS:34643-46-4; KEGG:C18405
xref_mesh: MESH:C032072
xref: PMID:10384797; PMID:11337831; PMID:11347620; PMID:12842175; PMID:17287007; PMID:17592615; PMID:19737786; PMID:20390940; PMID:21744237; PMID:3192132; PPDB:560; Reaxys:1998314
G
Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [prothiophos results in increased activity of AR protein]
CTD
PMID:15064155
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Esr1
estrogen receptor 1
increases activity
ISO
prothiophos results in increased activity of ESR1 protein
CTD
PMID:15064155
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
increases activity
ISO
prothiophos results in increased activity of ESR2 protein
CTD
PMID:15064155
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Hexb
hexosaminidase subunit beta
multiple interactions
EXP
zinc chloride inhibits the reaction [prothiophos results in increased secretion of HEXB protein]
CTD
PMID:15272608
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
prothiophos binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
prothiophos results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Tp53
tumor protein p53
affects activity
ISO
prothiophos metabolite affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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