Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Mofezolac (TN)
go back to main search page
Accession:CHEBI:31860 term browser browse the term
Synonyms:related_synonym: Formula=C19H17NO5;   InChI=1S/C19H17NO5/c1-23-14-7-3-12(4-8-14)18-16(11-17(21)22)25-20-19(18)13-5-9-15(24-2)10-6-13/h3-10H,11H2,1-2H3,(H,21,22);   InChIKey=DJEIHHYCDCTAAH-UHFFFAOYSA-N;   N-22;   SMILES=COC1=CC=C(C=C1)C2=C(ON=C2C3=CC=C(C=C3)OC)CC(=O)O
 alt_id: CHEBI:94048
 xref: CAS:78967-07-4;   Drug_Central:1829;   KEGG:D01718;   LINCS:LSM-4647
 xref_mesh: MESH:C054999


show annotations for term's descendants           Sort by:
Mofezolac (TN) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col10a1 collagen type X alpha 1 chain multiple interactions ISO [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 protein CTD PMID:27050768 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions ISO [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 protein CTD PMID:27050768 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP mofezolac inhibits the reaction [[PTGS2 protein results in increased chemical synthesis of Prostaglandins] which results in increased expression of FOS mRNA] CTD PMID:9450688 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO mofezolac inhibits the reaction [IL1A protein results in increased abundance of Dinoprostone] CTD PMID:15167967 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mofezolac inhibits the reaction [IL1B protein results in increased expression of IL1B mRNA] CTD PMID:9491209 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression
increases secretion		 ISO mofezolac results in increased expression of IL1RN mRNA
mofezolac results in increased secretion of IL1RN protein		 CTD PMID:9491209 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions
decreases expression
decreases activity		 ISO
EXP		 [mofezolac results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL10A1 protein; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 protein; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 protein
mofezolac results in decreased expression of PTGS1		 CTD PMID:21510291 PMID:27050768 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions		 EXP mofezolac results in decreased activity of PTGS2 protein
mofezolac inhibits the reaction [[PTGS2 protein results in increased chemical synthesis of Prostaglandins] which results in increased expression of FOS mRNA]		 CTD PMID:9450688 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions ISO [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 mRNA; [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of SOX9 protein CTD PMID:27050768 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          oxygen atom 19488
            oxygen molecular entity 19488
              organooxygen compound 19141
                ether 17259
                  aromatic ether 16509
                    methoxybenzenes 2049
                      Mofezolac (TN) 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                carbocyclic compound 18559
                                  benzenoid aromatic compound 17968
                                    benzenes 17830
                                      methoxybenzenes 2049
                                        Mofezolac (TN) 9
paths to the root