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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzonitrile
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Accession:CHEBI:27991 term browser browse the term
Definition:A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a phenyl group.
Synonyms:related_synonym: C6H5-CN;   Cyanobenzene;   Formula=C7H5N;   InChI=1S/C7H5N/c8-6-7-4-2-1-3-5-7/h1-5H;   InChIKey=JFDZBHWFFUWGJE-UHFFFAOYSA-N;   Phenyl cyanide;   SMILES=N#Cc1ccccc1;   benzenenitrile;   benzoic acid nitrile
 alt_id: CHEBI:22725;   CHEBI:3033
 xref: Beilstein:506893;   CAS:100-47-0;   Gmelin:2653;   KEGG:C09814;   MetaCyc:CPD-15582;   PMID:24129580;   UM-BBD_compID:c0367;   Wikipedia:Benzonitrile


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2,6-dichlorobenzonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 multiple interactions
increases expression		 ISO Dexamethasone inhibits the reaction [dichlobanil results in increased expression of IL6 protein] CTD PMID:23921153 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Por cytochrome p450 oxidoreductase decreases response to substance ISO POR protein results in decreased susceptibility to dichlobanil CTD PMID:20840855 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
cyanophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [cyanophos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
perampanel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of perampanel CTD PMID:35200000 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein] CTD PMID:36669621 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP perampanel inhibits the reaction [Kainic Acid results in increased expression of IL1B protein] CTD PMID:36669621 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP perampanel inhibits the reaction [Kainic Acid results in increased expression of TLR4 protein] CTD PMID:36669621 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        pseudohalo group 4566
          cyano group 4566
            nitrile 4566
              benzonitrile 7
                2,6-dichlorobenzonitrile 2
                2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile 0
                3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 0
                4-[(1S,2R)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile 0
                4-[(1S,2S)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile 0
                4-cyanophenol + 1
                benzonitrile oxide 0
                perampanel + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                carbocyclic compound 18559
                                  benzenoid aromatic compound 17968
                                    benzenes 17830
                                      benzonitrile 7
                                        2,6-dichlorobenzonitrile 2
                                        2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile 0
                                        3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 0
                                        4-[(1S,2R)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile 0
                                        4-[(1S,2S)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile 0
                                        4-cyanophenol + 1
                                        benzonitrile oxide 0
                                        perampanel + 4
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