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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Acta2 mRNA in Mdr2-/- mouse liver and liver myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adora2b |
adenosine A2B receptor |
multiple interactions |
ISO |
5'-S-methyl-5'-thioadenosine enhances the reaction [lipopolysaccharide increases expression of Adora2b mRNA in mouse liver myofibroblasts] |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:31712395 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Ccl2 mRNA in Mdr2-/- mouse liver and myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of cyclin-D1 mRNA in Mdr2-/- mouse liver myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
5'-methylthioadenosine results in decreased expression of COL1A1 mRNA 5'-S-methyl-5'-thioadenosine decreases expression of Col1a1 mRNA in Mdr2-/- mouse liver and liver myofibroblasts |
CTD RGD |
PMID:15983038 PMID:21209952 |
RGD:153297773 |
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
decreases expression |
ISO |
5'-methylthioadenosine results in decreased expression of COL1A2 mRNA |
CTD |
PMID:15983038 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
increases abundance multiple interactions |
ISO |
IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine] |
CTD |
PMID:27469509 |
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NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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G |
Ifng |
interferon gamma |
multiple interactions decreases secretion |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] 5'-methylthioadenosine results in decreased secretion of IFNG protein |
CTD |
PMID:17080400 PMID:31712395 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifnl1 |
interferon, lambda 1 |
multiple interactions |
ISO |
5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA] |
CTD |
PMID:37611859 |
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NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] |
CTD |
PMID:17080400 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
multiple interactions decreases secretion |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] 5'-methylthioadenosine results in decreased secretion of IL2 protein |
CTD |
PMID:17080400 PMID:31712395 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il33 |
interleukin 33 |
multiple interactions |
ISO |
5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] |
CTD |
PMID:37545493 |
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NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA] 5'-S-methyl-5'-thioadenosine decreases expression of Il6 mRNA in Mdr2-/- mouse liver |
CTD RGD |
PMID:17080400 PMID:21209952 |
RGD:153297773 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il7 |
interleukin 7 |
multiple interactions |
ISO |
IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:31712395 |
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NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of JunD protein in Mdr2-/- mouse liver myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Ltb |
lymphotoxin beta |
multiple interactions |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] |
CTD |
PMID:17080400 |
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NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
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G |
Mdm4 |
MDM4 regulator of p53 |
multiple interactions |
ISO |
5'-methylthioadenosine affects the splicing of and affects the expression of MDM4 mRNA alternative form |
CTD |
PMID:31712395 |
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NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Ki-67 protein in Mdr2-/- mouse liver |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp13 |
matrix metallopeptidase 13 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of MMP13 mRNA in Mdr2-/- mouse liver |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
5'-methylthioadenosine results in decreased phosphorylation of MTOR protein |
CTD |
PMID:31712395 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of iNOS mRNA in Mdr2-/- mouse liver |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Rps6 |
ribosomal protein S6 |
decreases phosphorylation |
ISO |
5'-methylthioadenosine results in decreased phosphorylation of RPS6 protein |
CTD |
PMID:31712395 |
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NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Tgfb1 mRNA in Mdr2-/- mouse liver myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfb2 |
transforming growth factor, beta 2 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Tgfb2 mRNA in Mdr2-/- mouse liver and myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tnc |
tenascin C |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of tenascin-C mRNA in Mdr2-/- mouse liver |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
5'-S-methyl-5'-thioadenosine inhibits the reaction [lipopolysaccharide increases expression of Tnf-alpha mRNA and protein in mouse liver myofibroblasts] |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
5'-methylthioadenosine results in increased expression of TP53 protein |
CTD |
PMID:31712395 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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