The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S,3R)-5-methyl-3-{[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-2-[(thiophen-2-ylsulfanyl)methyl]hexanoic acid with the amino group of hydroxylamine. It a broad-spectrum matrix metalloprotease inhibitor.
batimastat results in decreased secretion of AREG protein batimastat inhibits the reaction [pervanadate results in increased cleavage of AREG protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of AREG protein]
batimastat results in decreased activity of MAPK1 protein batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein]
batimastat results in decreased activity of MAPK3 protein batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]
batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; batimastat inhibits the reaction [TAC1 protein results in increased secretion of TGFA protein]
batimastat inhibits the reaction [TAC1 protein results in increased secretion of TGFA protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TGFA protein] batimastat results in decreased secretion of TGFA protein
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