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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:laquinimod
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Accession:CHEBI:134738 term browser browse the term
Synonyms:related_synonym: ABR-215062 sodium;   Formula=C19H17ClN2O3;   InChI=1S/C19H17ClN2O3/c1-3-22(12-8-5-4-6-9-12)19(25)16-17(23)15-13(20)10-7-11-14(15)21(2)18(16)24/h4-11,23H,3H2,1-2H3;   InChIKey=GKWPCEFFIHSJOE-UHFFFAOYSA-N;   SMILES=C1=CC=C(C2=C1N(C(C(=C2O)C(N(C3=CC=CC=C3)CC)=O)=O)C)Cl;   TV-5600;   laquinimod sodium
 xref: CAS:248282-07-7;   Drug_Central:4825
 xref_mesh: MESH:C476223


show annotations for term's descendants           Sort by:
laquinimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
affects binding		 EXP laquinimod analog results in increased activity of AHR protein
laquinimod analog binds to AHR protein		 CTD PMID:28433708 PMID:29908305 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP laquinimod analog results in increased expression of AHRR mRNA CTD PMID:28433708 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP
ISO		 laquinimod analog results in increased expression of CYP1A1 mRNA; laquinimod analog results in increased expression of CYP1A1 protein; laquinimod metabolite results in increased expression of CYP1A1 mRNA; laquinimod metabolite results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [laquinimod analog results in increased expression of CYP1A1 protein]		 CTD PMID:28433708 PMID:29908305 PMID:32668270 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP laquinimod analog results in increased expression of CYP1A2 mRNA CTD PMID:28433708 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions		 EXP
ISO		 laquinimod analog results in increased expression of CYP1B1 mRNA; laquinimod metabolite results in increased expression of CYP1B1 mRNA
Progesterone promotes the reaction [laquinimod metabolite results in increased expression of CYP1B1 mRNA]		 CTD PMID:28433708 PMID:32668270 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing		 ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod] CTD PMID:15764719 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP laquinimod analog results in increased expression of NQO1 mRNA CTD PMID:28433708 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          nitrogen atom 18933
            nitrogen molecular entity 18933
              amide 17756
                aromatic amide 8435
                  laquinimod 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic aromatic compound 19336
                                  aromatic amide 8435
                                    laquinimod 7
paths to the root