Alas1 (5'-aminolevulinate synthase 1) - Rat Genome Database

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Gene: Alas1 (5'-aminolevulinate synthase 1) Rattus norvegicus
Analyze
Symbol: Alas1
Name: 5'-aminolevulinate synthase 1
RGD ID: 68392
Description: Enables 5-aminolevulinate synthase activity. Involved in several processes, including cellular response to insulin stimulus; response to herbicide; and response to nickel cation. Predicted to be located in cytosol; mitochondrial inner membrane; and nucleoplasm. Predicted to be active in mitochondrial matrix. Biomarker of porphyria and pulmonary hypertension. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1); PARTICIPATES IN heme biosynthetic pathway; acute intermittent porphyria pathway; dihydropyrimidine dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 1,2,4-trichlorobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-aminolevulinate synthase 1; 5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALA-S; ALAS; ALAS-H; ALAS-N; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; delta-ALA synthase 1; delta-ALA synthetase; delta-aminolevulinate synthase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,755,238 - 115,768,642 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8115,755,238 - 115,768,642 (-)EnsemblGRCr8
mRatBN7.28106,876,514 - 106,889,917 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,876,514 - 106,889,917 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8112,500,993 - 112,514,445 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,700,156 - 110,713,609 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,542,951 - 108,556,413 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08114,927,704 - 114,941,038 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,927,722 - 114,940,177 (-)Ensemblrn6Rnor6.0
Rnor_5.08114,289,617 - 114,302,413 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera8106,197,419 - 106,210,677 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2,4-trichlorobenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,6-dioxoheptanoic acid  (ISO)
5-aminolevulinic acid  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
Ampullosporin  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP)
brequinar  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorobenzene  (EXP)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
ferric oxide  (EXP)
ferroheme b  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fomesafen  (ISO)
genistein  (EXP)
glafenine  (EXP)
gossypol  (EXP)
griseofulvin  (ISO)
heme b  (ISO)
hemin  (EXP)
hydrazine  (ISO)
hyperforin  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methacrylate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
methyltestosterone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nimesulide  (EXP)
Nonylphenol  (EXP)
okadaic acid  (ISO)
organophosphorus compound  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP)
propiconazole  (ISO)
pyridine  (EXP)
quercetin  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
selenium atom  (ISO)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
2. Free heme pool and activity of key enzyme of heme synthesis in the rat liver under action of agents affecting reduced glutathione level. Barannik TV, etal., Ukr Biokhim Zh. 2005 Sep-Oct;77(5):120-2.
3. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
4. Heme and hemoproteins in streptozotocin-diabetic female rats. Bitar M and Weiner M, Biochem Pharmacol. 1983 Jun 15;32(12):1921-8.
5. Testing the porphyrinogenicity of propofol in a primed rat model. Bohrer H, etal., Br J Anaesth. 1995 Sep;75(3):334-8.
6. Regulation of heme metabolism in rat hepatocytes and hepatocyte cell lines: delta-aminolevulinic acid synthase and heme oxygenase are regulated by different heme-dependent mechanisms. Cable EE, etal., Arch Biochem Biophys. 2000 Dec 15;384(2):280-95.
7. Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis. Fujii H, etal., Crit Care Med. 2003 Mar;31(3):893-902.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Handschin C, etal., Cell. 2005 Aug 26;122(4):505-15.
12. Potential role of lipin-1 in exercise-induced mitochondrial biogenesis. Higashida K, etal., Biochem Biophys Res Commun. 2008 Sep 26;374(3):587-91. Epub 2008 Jul 24.
13. Developmental changes of gene expression in heme metabolic enzymes in rat placenta. Ihara N, etal., FEBS Lett. 1998 Nov 13;439(1-2):163-7.
14. Increased pulmonary heme oxygenase-1 and delta-aminolevulinate synthase expression in monocrotaline-induced pulmonary hypertension. Iwasaki T, etal., Curr Neurovasc Res. 2005 Apr;2(2):133-9.
15. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
16. Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species. Lelli SM, etal., Toxicology. 2005 Dec;216(1):49-58. Epub 2005 Aug 24.
17. Enzymes of heme metabolism in the kidney: regulation by trace metals which do not form heme complexes. Maines MD and Kappas A, J Exp Med. 1977 Nov 1;146(5):1286-93.
18. Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver. Maines MD, etal., Proc Natl Acad Sci U S A. 1976 May;73(5):1499-503.
19. Induction of 5-aminolevulinate synthase by activators of steroid biosynthesis. Martini CN, etal., Life Sci. 2007 Jun 13;81(1):19-25. Epub 2007 May 1.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxygenase-1, biliverdin IXalpha reductase and delta-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor. Niittynen M, etal., Toxicology. 2008 Sep 4;250(2-3):132-42. Epub 2008 Jul 10.
23. Bilirubin is highly effective in preventing in vivo delta-aminolevulinic acid-induced oxidative cell damage. Noriega GO, etal., Biochim Biophys Acta 2003 Jul 14;1638(2):173-8.
24. Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase. Noriega GO, etal., Free Radic Res. 2002 Jun;36(6):633-9.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin. Scassa ME, etal., Exp Cell Res. 2001 Dec 10;271(2):201-13.
31. Gonadotropin regulation of genes differentially expressed in response to PKCzeta inhibitor during ovulation in the rat. Seo YM, etal., Life Sci. 2009 Jul 17;85(3-4):153-60. Epub 2009 May 22.
32. Regulation of 5-aminolevulinate synthase mRNA in different rat tissues. Srivastava G, etal., J Biol Chem 1988 Apr 15;263(11):5202-9.
33. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
34. Structure, turnover, and heme-mediated suppression of the level of mRNA encoding rat liver delta-aminolevulinate synthase. Yamamoto M, etal., J Biol Chem 1988 Nov 5;263(31):15973-9.
35. Haeme-regulated degradation of delta-aminolevulinate synthase 1 in rat liver mitochondria. Yoshino K, etal., J Biochem. 2007 Oct;142(4):453-8. Epub 2007 Aug 30.
36. Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol. Zheng J, etal., FEBS Lett. 2008 Jun 11;582(13):1829-34. Epub 2008 May 8.
Additional References at PubMed
PMID:8093450   PMID:15489334   PMID:18614015   PMID:25416956   PMID:26102301  


Genomics

Comparative Map Data
Alas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,755,238 - 115,768,642 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8115,755,238 - 115,768,642 (-)EnsemblGRCr8
mRatBN7.28106,876,514 - 106,889,917 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,876,514 - 106,889,917 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8112,500,993 - 112,514,445 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,700,156 - 110,713,609 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,542,951 - 108,556,413 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08114,927,704 - 114,941,038 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,927,722 - 114,940,177 (-)Ensemblrn6Rnor6.0
Rnor_5.08114,289,617 - 114,302,413 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera8106,197,419 - 106,210,677 (-)NCBICelera
Cytogenetic Map8q32NCBI
ALAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,198,083 - 52,214,327 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,198,086 - 52,214,585 (+)Ensemblhg38GRCh38
GRCh37352,232,099 - 52,248,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,207,156 - 52,223,383 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34352,207,155 - 52,223,383NCBI
Celera352,211,428 - 52,227,655 (+)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef352,294,291 - 52,310,540 (+)NCBIHuRef
CHM1_1352,184,622 - 52,200,871 (+)NCBICHM1_1
T2T-CHM13v2.0352,230,963 - 52,247,212 (+)NCBIT2T-CHM13v2.0
Alas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,110,654 - 106,125,153 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,110,654 - 106,125,853 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389106,233,455 - 106,247,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,233,455 - 106,248,654 (-)Ensemblmm10GRCm38
MGSCv379106,135,786 - 106,150,285 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369106,092,028 - 106,105,957 (-)NCBIMGSCv36mm8
Celera9105,859,658 - 105,874,969 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.46NCBI
Alas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,810,464 - 3,823,456 (+)Ensembl
ChiLan1.0NW_0049555323,810,469 - 3,823,456 (+)NCBIChiLan1.0ChiLan1.0
ALAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,193,522 - 52,209,739 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,198,293 - 52,214,496 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,140,423 - 52,156,656 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,369,522 - 53,385,368 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,369,522 - 53,385,361 (+)EnsemblpanPan2panpan1.1
ALAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,552,813 - 37,566,417 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,552,814 - 37,566,638 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2037,534,362 - 37,548,005 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02037,903,373 - 37,917,010 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,903,390 - 37,917,219 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,267,049 - 37,280,686 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,675,598 - 37,689,231 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,960,645 - 37,974,293 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Alas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560266,757,839 - 66,771,345 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365293,518,322 - 3,531,845 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365293,518,337 - 3,531,842 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,333,113 - 34,347,589 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11334,333,263 - 34,347,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,658,029 - 37,666,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,558,011 - 13,573,740 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,559,180 - 13,575,869 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041153,328,129 - 153,345,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247305,984,766 - 6,001,667 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247305,984,764 - 5,998,929 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Alas1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1897,540,805 - 97,554,397 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Alas1
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:19
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000075549
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083303   ⟹   ENSRNOP00000070835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8106,876,514 - 106,888,304 (-)Ensembl
Rnor_6.0 Ensembl8114,927,722 - 114,940,163 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086232   ⟹   ENSRNOP00000074873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8115,755,238 - 115,768,642 (-)Ensembl
mRatBN7.2 Ensembl8106,876,514 - 106,889,917 (-)Ensembl
Rnor_6.0 Ensembl8114,927,789 - 114,940,177 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094470   ⟹   ENSRNOP00000084314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8115,756,773 - 115,765,325 (-)Ensembl
mRatBN7.2 Ensembl8106,878,049 - 106,888,304 (-)Ensembl
RefSeq Acc Id: NM_024484   ⟹   NP_077810
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88115,755,238 - 115,768,642 (-)NCBI
mRatBN7.28106,876,514 - 106,889,917 (-)NCBI
Rnor_6.08114,927,704 - 114,941,038 (-)NCBI
Rnor_5.08114,289,617 - 114,302,413 (-)NCBI
Celera8106,197,419 - 106,210,677 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077810 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA13063 (Get FASTA)   NCBI Sequence Viewer  
  AAA40724 (Get FASTA)   NCBI Sequence Viewer  
  AAA40790 (Get FASTA)   NCBI Sequence Viewer  
  AAH61793 (Get FASTA)   NCBI Sequence Viewer  
  ABB72479 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074873
GenBank Protein P13195 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077810   ⟸   NM_024484
- Peptide Label: precursor
- UniProtKB: Q6P782 (UniProtKB/Swiss-Prot),   P13195 (UniProtKB/Swiss-Prot),   A6I2Q2 (UniProtKB/TrEMBL),   A0A0G2K962 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070835   ⟸   ENSRNOT00000083303
Ensembl Acc Id: ENSRNOP00000074873   ⟸   ENSRNOT00000086232
Ensembl Acc Id: ENSRNOP00000084314   ⟸   ENSRNOT00000094470
Protein Domains
5-aminolevulinate synthase presequence   Aminotransferase class I/classII large

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13195-F1-model_v2 AlphaFold P13195 1-642 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68392 AgrOrtholog
BioCyc Gene G2FUF-29248 BioCyc
BioCyc Pathway PWY-5189 [tetrapyrrole biosynthesis II (from glycine)] BioCyc
BioCyc Pathway Image PWY-5189 BioCyc
Ensembl Genes ENSRNOG00000056596 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000086232 ENTREZGENE
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5597891 IMAGE-MGC_LOAD
InterPro 4pyrrol_synth_NH2levulA_synth UniProtKB/Swiss-Prot
  5aminolev_synth_preseq UniProtKB/Swiss-Prot
  Aminotrans_II_pyridoxalP_BS UniProtKB/Swiss-Prot
  Aminotransferase_I/II UniProtKB/Swiss-Prot
  AON_synthase_class-II UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
KEGG Report rno:65155 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72423 IMAGE-MGC_LOAD
NCBI Gene 65155 ENTREZGENE
PANTHER 5-AMINOLEVULINATE SYNTHASE, NONSPECIFIC, MITOCHONDRIAL UniProtKB/Swiss-Prot
  CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE UniProtKB/Swiss-Prot
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot
  Preseq_ALAS UniProtKB/Swiss-Prot
PhenoGen Alas1 PhenoGen
PROSITE AA_TRANSFER_CLASS_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056596 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt A0A0G2K962 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXT7_RAT UniProtKB/TrEMBL
  A6I2Q2 ENTREZGENE, UniProtKB/TrEMBL
  A6I2Q3_RAT UniProtKB/TrEMBL
  A6I2Q4_RAT UniProtKB/TrEMBL
  HEM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2XTB1_RAT UniProtKB/TrEMBL
  Q6P782 ENTREZGENE
UniProt Secondary Q6P782 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-01 Alas1  5'-aminolevulinate synthase 1  Alas1  aminolevulinate, delta-, synthase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Alas1  aminolevulinate, delta-, synthase 1  Alas1  aminolevulinic acid synthase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Alas1  aminolevulinic acid synthase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in all tissues examined 68214
gene_protein 642 amino acids 632013
gene_regulation transcription inhibited by heme 68214
gene_regulation transcription inhibited by heme 632013