*New MOET v.2 formula
Further, p-value is calculated as:
X = a random variable n = size of the input gene list N = total number of genes in the reference population k = number of genes annotated to a ontology term in the input list M = number of genes annotated to the ontology term in the reference population. The reference population for the Hypergeometric test in MOET includes all the genes in the selected species annotated for that term.
*Additional feature in MOET v.2
a = annotated input gene count = k c = annotated ref gene count – a = M – k b = input gene count – a = n – k d = ref gene count – annotated ref gene count – b = N – M – n + k
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.