miRNAs (microRNAs) have emerged as important regulators of gene expression primarily acting as translational repressors. In addition, aberrant expression of miRNAs themselves has been associated with cancer; deletion, down- or up-regulation of particular miRNAs genes appears to link to distinct types of cancer [see PMID 20422339]. Tens of aberrantly expressed genes have been associated with prostate cancer but due to a number of factors, results are sometimes controversial. However, for several of these genes there appears to be consensus in the literature. Several differentially-expressed genes in human prostate tumors are listed with links to their entries in RGD and miRBase. For more information, check PMID 19779034 and references therein. [Some equivalent rat and mouse miRNAs can also be found at RGD and miRBase].

Downregulated
MIR15A – RGD, miRBase
MIR16-1 – RGD, miRBase
MIR101-1 – RGD, miRBase
MIR101-2 – RGD, miRBase
MIR449A – RGD, miRBase
MIR146A – RGD, miRBase
MIR205 – RGD, miRBase

Upregulated
MIR221 – RGD, miRBase
MIR222 – RGD, miRBase
MIR21 – RGD, miRBase