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Pathways
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Canonical Wnt signaling pathway

The planar cell polarity Wnt signaling pathway

Notch signaling pathway

Wnt signaling pathway plays vital roles in the control of embryonic development, tissues regeneration, cell polarity and proliferation, and cell fate determination.  The canonical, beta-catenin dependent Wnt pathway is the better understood system. Click here to explore this important signaling pathway.To examine the altered canonical Wnt signaling pathway, click here.

 

 

The planar cell polarity Wnt signaling pathway (PCP) belongs to the
non-canonical Wnt signaling and plays major roles in embryonic tissue
patterning, cell polarization and migration and in morphogenesis. While
PCP signaling is less well understood and characterized than the
canonical one, evidence is accumulating regarding the core components
and their roles.  Click here to explore this important signaling
pathway.

 

 

Notch signaling is a highly conserved cell-cell signaling pathway that
plays essential roles in the control of cell fate determination and
differentiation and cell proliferation. The Notch receptors and ligands
are single-transmembrane proteins that connect the cell-receiving and
the cell-sending signal. Click here to explore this important signaling
pathway.

 

 

Hedgehog signaling pathway

Transforming Growth Factor-beta Smad dependent signaling pathway

Hedgehog signaling pathway, first discovered in Drosophila, is a key regulator of mammalian embryogenesis and plays important roles in cell proliferation and differentiation.  Click here to explore this complex signaling pathway.

 Transforming growth factor-beta superfamily mediated pathways are central regulators of embryonic development, proliferation and survival, migration and differentiation, angiogenesis and wound healing.  The superfamily can be divided into two main groups that can be further subdivided.  The transforming growth factor-beta Smad-dependent pathway is among the best characterized ones.  Click here to explore this important signaling pathway. To examine the altered transforming growth factor-beta Smad dependent signaling pathway, click here.

 


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.