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Strain Registration

General

Strain: FHH/EurMcwi
Symbol:	FHH/EurMcwi
Strain:	FHH
Substrain:	EurMcwi
RGD ID:	629509
Citation ID:	RRID:RRRC_00293
Ontology ID:	RS:0000342
Variant(s):	rs106411696; rs105487995; rgdv393055223; rs105373896; rs105278863
Also Known As:	MDC-03-07
Type:	inbred
Available Source:	Rat Resource and Research Center, RGD HRDP, contact HRDP
Origination:	PhysGen
Description:	An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University.
Coat Color:	Fawn hood
Last Known Status:	Live Animals; Cryorecovery
Portal(s):	HRDP portal

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (IAGP)

glomerulosclerosis (IAGP)

proteinuria (IAGP,IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal actin cytoskeleton morphology (IMP)

abnormal blood vessel physiology (IAGP)

abnormal glomerular filtration barrier function (IAGP)

abnormal renal glomerulus morphology (IMP)

abnormal renal plasma flow rate (IAGP)

decreased physiological sensitivity to xenobiotic (IAGP)

decreased tubuloglomerular feedback response (IMP)

decreased vascular permeability (IMP)

increased mean systemic arterial blood pressure (IAGP)

increased urine protein level (IAGP)

renal cast (IMP)

renal fibrosis (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

blood urea nitrogen level

plasma anion gap

heart wet weight

heart left ventricle wet weight

heart right ventricle wet weight

heart weight to body weight ratio

body length, nose to tail

body length, nose to rump

left kidney wet weight

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation

arterial blood flow rate

tidal volume

timed urine volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

both kidneys wet weight to body weight ratio

serum triglyceride level

serum total cholesterol level

total white blood cell count

serum total bilirubin level

blood pH

partial pressure of blood oxygen

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

liver weight to body weight ratio

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

water drink intake rate

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine potassium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

renal blood flow rate

ratio of change in renal blood flow to change in renal perfusion pressure

urine albumin excretion rate to body weight ratio

creatinine clearance to total kidney weight ratio

serum globulin level

References

References - curated

#	Reference Title	Reference Citation
1.	A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease.	Fan F, etal., J Am Soc Nephrol. 2020 Apr;31(4):687-700. doi: 10.1681/ASN.2019080784. Epub 2020 Feb 6.
2.	Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats.	Lopez B, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22.
3.	Initial characterization of a rat model of diabetic nephropathy.	Nobrega MA, etal., Diabetes 2004 Mar;53(3):735-42.
4.	Role of genetic modifiers in an orthologous rat model of ARPKD.	O'Meara CC, etal., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5.
5.	PhysGen Strains	PhysGen strains
6.	RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat.	Rangel-Filho A, etal., J Am Soc Nephrol 2005 Apr;16(4):852-6. Epub 2005 Mar 9.
7.	Rab38 modulates proteinuria in model of hypertension-associated renal disease.	Rangel-Filho A, etal., J Am Soc Nephrol. 2013 Feb;24(2):283-92. doi: 10.1681/ASN.2012090927. Epub 2013 Jan 4.
8.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
9.	SNP and haplotype mapping for genetic analysis in the rat.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
10.	Impaired autoregulation of renal blood flow in the fawn-hooded rat.	Van Dokkum RP, etal., Am J Physiol 1999 Jan;276(1 Pt 2):R189-96
11.	Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat.	van Dokkum RP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R855-63
12.	Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L-NAME-induced hypertension in rats.	van Dokkum RP, etal., Nephrol Dial Transplant 2000 Sep;15(9):1337-43.

Region

Strain QTL Data

Symbol	Name	Trait
Rf55	Renal function QTL 55	renal blood flow trait (VT:2000006)

Strain Samples in RGD with Damaging Variants (Polyphen)


Assembly	Sample
RGSC_v3.4	FHH/EurMcwi (MDC)	View Damaging Variants
RGSC_v3.4	FHH/EurMcwi (MCW)	View Damaging Variants
RGSC_v3.4	FHH/EurMcwi (ICL)	View Damaging Variants
Rnor_5.0	FHH/EurMcwi (MCW)	View Damaging Variants
Rnor_5.0	FHH/EurMcwi (KNAW)	View Damaging Variants
Rnor_6.0	FHH/EurMcwi (MCW)	View Damaging Variants
Rnor_6.0	FHH/EurMcwi (RGD)	View Damaging Variants
Rnor_6.0	FHH/EurMcwi (2019)	View Damaging Variants
mRatBN7.2	FHH/EurMcwi (2019)	View Damaging Variants
mRatBN7.2	FHH/EurMcwi (2019NG)	View Damaging Variants

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
rs106411696	chr1	242400065	242400065	G	A	sequence_variant	RGSC_v3.4
rs105487995	chr1	224399836	224399836	T	G	sequence_variant	RGSC_v3.4
rgdv393055223	chr1	249700115	249700115	G	A	sequence_variant	RGSC_v3.4
rs105373896	chr1	252800388	252800388	G	A	sequence_variant	RGSC_v3.4
rs105278863	chr1	261199574	261199574	C	T	sequence_variant	RGSC_v3.4

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	L-NAME along with unilateral nephrectomy causes increase in blood pressure that is dose dependent. F₁ rats develop severe hypertension, more functional and structural renal damage with increase in systolic blood pressure.	1357424
strain_drgs_chems	L-NAME (N-nitro-L-arginine methyl ester) induces hypertension that can be prevented by lisinopril (LIS) which can prevent the development of functional and structural renal damage.	1357424
strain_life_disease	These carry several genes which make them susceptible to renal damage.	1357424
strain_life_disease	The blood pressure of females is 129 mmHg and of males is 131 mmHg.	629526
strain_other	The average weight of females is 202g and of males 303g.	629526
strain_reproduction	The average litter size is 8.5 pups and the generation time is 41 days.	629526

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-12	FHH/EurMcwi		FHH/EurMcwi		Name updated	68913	APPROVED
2013-08-12	FHH/EurMcwi		FHH/EurMcwi		Name updated	68913	APPROVED

External Database Links

Database	Acc Id	Source(s)
RRRC	RRRC:00293	RGD

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: FHH/EurMcwi

Mammalian Phenotype

Related Phenotype Data for Term "FHH/EurMcwi" (RS:0000342)