Phenominer Database Results (1551 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH/EurMcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 60.78 ml/min 2.92 19.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14564 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 0.0 null 0.02 0.03 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14895 381
FHH/EurMcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.41 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14900 381
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 21.68 mmHg 7.01 17.16 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51814 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 116.75 mmHg 1.54 4.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51820 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 6.46 mmHg 2.32 6.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51863 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 7.1 mmHg 2.79 8.38 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51872 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.27 mg/dl 0.01 0.04 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51901 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -11.7 beats/min 12.08 34.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51700 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -36.4 beats/min 20.58 50.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51714 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 8.33 beats/min 25.63 62.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51728 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 15.53 beats/min 17.94 50.74 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51795 481
FHH/EurMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 8 27.77 mg/d 8.31 23.49 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51434 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 420.76 beats/min 4.93 13.05 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51483 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.28 mg/dl 0.02 0.04 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51539 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -19.53 beats/min 25.96 63.58 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51609 481
FHH/EurMcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 143.63 % 3.58 23.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54086 381
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 2 31.74 mmHg 13.43 18.99 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50846 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 12.14 beats/min 6.37 16.86 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50906 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 7.16 mmHg 5.12 13.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50919 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 122.0 mmHg 3.95 8.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51140 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 14.94 mmHg 4.87 11.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51194 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -18.95 beats/min 21.78 61.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51208 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 431.85 beats/min 7.73 20.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51244 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 32.74 mmHg 4.09 9.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50748 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 25.72 mmHg 4.1 11.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50758 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 0.93 mmHg 2.33 6.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50780 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 43.49 mmHg 2.68 6.55 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50786 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 2 27.32 mmHg 13.75 19.45 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50790 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 142.26 mmHg 3.59 10.14 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50799 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 7.2 ng/ml/h 1.34 2.68 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51013 481
FHH/EurMcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.41 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13645 381
FHH/EurMcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 -0.34 degrees C 0.14 0.49 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14135 381
FHH/EurMcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 156.95 % 10.95 36.31 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14141 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14155 381
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 396.6 beats/min 21.2 29.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50324 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 377.14 beats/min 16.4 43.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50329 481
FHH/EurMcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 %change=VE during7-9 min hypercapnia/control during standard conditions 205.71 % 7.5 49.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14262 381
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 9 11.85 ng/ml/h 0.69 2.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50394 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 8 11.19 beats/min 19.05 53.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50503 481
FHH/EurMcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 11 119.62 mmHg 3.34 11.09 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13505 381
FHH/EurMcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 11 220.3 g 5.4 17.8 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17925 381
FHH/EurMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 381.52 beats/min 4.16 5.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17739 381
FHH/EurMcwi blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17606 381
FHH/EurMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 2 38.05 degrees C 0.55 0.78 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18125 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 119.31 mmHg 7.58 20.05 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19520 381
FHH/EurMcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 -0.26 degrees C 0.28 0.8 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19579 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -41.67 mmHg 7.22 12.51 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18644 381
FHH/EurMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 9.3 mg/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36605 401
FHH/EurMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 13 9.42 mg/dl 0.14 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36782 401
FHH/EurMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 49 9.68 mg/dl 0.06 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36801 401
FHH/EurMcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 28 38.84 cm 0.42 2.22 in vivo ruler method 0 63698 529
FHH/EurMcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 170 42.3 cm 0.15 1.96 in vivo ruler method 0 63709 529
FHH/EurMcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 28 0.53 g 0.01 0.06 digital scale post excision weight measurement 0 63770 529
FHH/EurMcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 260.9 % 17.85 56.44 stop flow air displacement plethysmography 0 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19047 381
FHH/EurMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 49 5.41 g/dl 0.08 0.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37240 401
FHH/EurMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 4.01 x 1000 cells/ul 0.35 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37306 401
FHH/EurMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 13 260.85 U/l 12.99 46.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37473 401
FHH/EurMcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 62.2 mmHg 6.18 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49819 461
FHH/EurMcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 6 1.35 g 0.05 0.12 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49826 461
FHH/EurMcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 6 1.59 g 0.07 0.16 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49827 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 6 35.45 % 9.21 22.56 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49851 461
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 260.21 beats/min 29.81 94.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 50310 461
FHH/EurMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 140.49 beats/min 33.33 88.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19171 381
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.37 IU/g 0.07 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49680 461
FHH/EurMcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70 days-84 days 172 0.21 g 0.0 0.04 digital scale post excision weight measurement 0 63319 529
FHH/EurMcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 18 141.33 mmol/l 0.86 3.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39440 401
FHH/EurMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.86 g/dl 0.06 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39529 401
FHH/EurMcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 51 105.61 U/l 4.06 28.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42833 401
FHH/EurMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 13 0.18 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42669 401
FHH/EurMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 48 17.25 pg 0.05 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40240 401
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.23 mmHg x min x kg x ml-1 0.02 0.06 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 59032 526
FHH/EurMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 48 0.19 x 1000 cells/ul 0.02 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40336 401
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 4 13.32 ml/min/kg 1.08 2.16 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 58997 526
FHH/EurMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 8 1.05 g/kg 0.12 0.34 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 59015 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 19 4.0 mg/kg 1.04 4.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58958 526
FHH/EurMcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 119.75 % 7.07 22.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53551 381
FHH/EurMcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.41 % 9.21 27.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53554 381
FHH/EurMcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 140.04 % 11.02 36.55 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53591 381
FHH/EurMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 13 44.25 % 0.85 3.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41325 401
FHH/EurMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 48 42.71 % 0.44 3.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41344 401
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 54 0.17 mmHg x min x kg x ml-1 0.0 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59610 526
FHH/EurMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 13.75 ml/min/kg 1.22 2.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 59638 526
FHH/EurMcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 349.16 beats/min 39.15 95.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46512 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.34 ml/min/g 1.0 3.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46520 461
FHH/EurMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 112 1.31 E-7mole 0.1 1.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63038 528
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 49 0.27 IU/g 0.02 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47476 461
FHH/EurMcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 6.14 mmHg 0.8 2.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47537 461
FHH/EurMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 80.13 % 5.01 12.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48511 461
FHH/EurMcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 93.29 mmHg 8.38 22.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48728 461
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 6 -7.47 null 0.16 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55711 522
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 27.86 mmHg 0.76 2.28 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16448 381
FHH/EurMcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 25 53.59 fl 0.31 1.55 automated blood cell counting method 0 60779 527
FHH/EurMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 -8.21 null 0.15 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56028 522
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 38.73 % 7.27 24.1 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54975 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 5 -7.39 null 0.08 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56173 522
FHH/EurMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 1.56 g/mg 0.12 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56215 522
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 4 7.96 ml/min/kg 1.01 2.02 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60082 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 3 1.09 null 0.12 0.2 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60090 526
FHH/EurMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 0.09 10E-7mol/l 0.07 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56693 522
FHH/EurMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 0.01 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56699 522
FHH/EurMcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount male 70 days-84 days 158 64.27 U/l 8.37 105.18 standard blood chemistry panel 0 61488 527
FHH/EurMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.63 umol/l 0.15 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56882 522
FHH/EurMcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount female 70 days-84 days 25 7.67 mg/dl 0.21 1.06 standard blood chemistry panel 0 61569 527
FHH/EurMcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 134.35 mmHg 4.77 13.5 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14411 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.42 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14425 381
FHH/EurMcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.36 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15286 381
FHH/EurMcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 0.29 ml 0.01 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15297 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 7.47 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15318 381
FHH/EurMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 13 460.69 beats/min 54.79 197.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15948 381
FHH/EurMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 2 -0.75 degrees C 0.15 0.21 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16002 381
FHH/EurMcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 76.05 ml/min 4.5 14.92 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14639 381
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 21.3 mmHg 5.11 14.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15144 381
FHH/EurMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 474.88 beats/min 17.79 39.79 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15192 381
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -65.74 beats/min 24.24 72.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 52057 481
FHH/EurMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 48 472.36 mg/d 30.23 209.46 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52115 482
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 12.93 ng/ml/h 1.15 2.3 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50571 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -52.77 beats/min 23.98 67.84 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50597 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -1.4 beats/min 7.97 22.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50622 481
FHH/EurMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 48 1.26 mEq/d 0.05 0.38 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52313 482
FHH/EurMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 39 1.44 ml/min 0.09 0.57 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52360 482
FHH/EurMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 15 429.33 beats/min 8.27 32.03 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52487 482
FHH/EurMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 38 2.57 ng/ml/h 0.36 2.21 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52899 482
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.27 ml/min 0.15 0.33 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51943 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 8 -11.05 beats/min 21.23 60.05 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 52048 481
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 -0.02 null 0.02 0.04 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13861 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 106.56 mmHg 3.37 8.25 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17301 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 3 490.57 beats/min 20.05 34.73 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13827 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 37.64 mmHg 1.34 3.79 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 13843 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 1.07 mmHg 8.05 19.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14020 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 9.8 mmHg 5.2 12.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14025 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 514.24 beats/min 11.72 31.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14069 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 3 26.9 mmHg 0.91 1.57 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20999 381
FHH/EurMcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 138.45 % 8.14 31.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53750 381
FHH/EurMcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 49 121.35 % 3.9 27.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53754 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 -5.91 mmHg 0.71 1.42 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20019 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 5 134.67 mmHg 6.99 15.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19705 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 125.15 mmHg 9.63 25.47 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19710 381
FHH/EurMcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 113.88 % 4.92 19.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53882 381
FHH/EurMcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 116.27 % 4.95 19.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53983 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 19.65 mmHg 3.47 9.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20868 381
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 10.89 mmHg 0.64 0.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20725 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 99.22 mmHg 3.82 10.8 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20034 381
FHH/EurMcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 57.94 ml/min 5.35 18.53 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20126 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 115.68 mmHg 3.64 10.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19868 381
FHH/EurMcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 50 390.88 U/l 9.22 65.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36442 401
FHH/EurMcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 39.71 ml/min 1.83 12.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18726 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 3 34.47 mmHg 2.47 4.27 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18996 381
FHH/EurMcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 49 133.43 breaths/min 3.84 26.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18329 381
FHH/EurMcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 18 70.17 mg/dl 2.03 8.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37149 401
FHH/EurMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 7 279.86 U/l 4.19 11.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37059 401
FHH/EurMcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.23 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37066 401
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 5 30.27 mmHg 0.64 1.42 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18166 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 29.33 mmHg 1.22 2.11 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18170 381
FHH/EurMcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.52 ml 0.02 0.06 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18178 381
FHH/EurMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 417.93 beats/min 18.7 49.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18200 381
FHH/EurMcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.02 degrees C 0.1 0.3 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18230 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.44 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20190 381
FHH/EurMcwi absolute change in blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20544 381
FHH/EurMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 49 103.06 U/l 3.29 23.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42459 401
FHH/EurMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.51 x 10E6 cells/ul 0.19 0.53 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 42378 401
FHH/EurMcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 18 16.17 mmol/l 0.75 3.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42114 401
FHH/EurMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 28 189.79 g 2.74 14.52 whole body digital scale 0 63626 529
FHH/EurMcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 16 52.99 % 0.9 3.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39043 401
FHH/EurMcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 47 55.55 % 0.52 3.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39054 401
FHH/EurMcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 18.71 mmol/l 1.6 4.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39090 401
FHH/EurMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 13 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42906 401
FHH/EurMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 49 0.1 mg/dl 0.0 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42925 401
FHH/EurMcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 146.1 % 3.65 23.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54426 381
FHH/EurMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 13 22.62 mmol/l 1.83 6.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43154 401
FHH/EurMcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 46 55.29 % 0.42 2.83 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59320 526
FHH/EurMcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 18 1.76 g/dl 0.04 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40602 401
FHH/EurMcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 50 1.7 g/dl 0.05 0.35 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40613 401
FHH/EurMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 3.44 x 1000 cells/ul 0.52 1.46 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40635 401
FHH/EurMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 5.11 x 1000 cells/ul 0.39 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40641 401
FHH/EurMcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 18 52.56 U/l 3.75 15.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40766 401
FHH/EurMcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 32.13 g/dl 0.1 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40530 401
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 56 3.23 mg/kg 0.36 2.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59206 526
FHH/EurMcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 7.85 mg/dl 0.36 1.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37646 401
FHH/EurMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 61.75 U/l 4.28 12.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37679 401
FHH/EurMcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 16 3.71 x 1000 cells/ul 0.51 2.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40978 401
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 13 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59381 526
FHH/EurMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 15.15 g/dl 0.34 0.95 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41622 401
FHH/EurMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.86 g/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41834 401
FHH/EurMcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 16 3.07 x 1000 cells/ul 0.43 1.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41555 401
FHH/EurMcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 49 4.14 x 1000 cells/ul 0.26 1.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41566 401
FHH/EurMcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 58.81 fl 0.27 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38165 401
FHH/EurMcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 16 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41699 401
FHH/EurMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 13 14.92 mg/dl 0.77 2.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41775 401
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.27 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59795 526
FHH/EurMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 13 0.02 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41427 401
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 -8.35 null 0.09 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55289 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 50 -7.86 null 0.05 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55308 522
FHH/EurMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 -6.76 null 0.06 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55372 522
FHH/EurMcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 158 43.69 % 0.34 4.23 automated blood cell counting method 0 60678 527
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 13.85 mmHg 4.05 5.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16284 381
FHH/EurMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 29.65 ml/min 1.65 5.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16200 381
FHH/EurMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 28.66 ml/min 1.48 9.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16211 381
FHH/EurMcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70 days-84 days 158 5.1 mmol/l 0.12 1.51 flame atomic emission spectrometry 0 61344 527
FHH/EurMcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70 days-84 days 157 5.08 x 1000 cells/ul 0.19 2.33 automated blood cell counting method 0 61416 527
FHH/EurMcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 52 43.96 ml/min/kg 2.44 17.56 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58062 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 51 0.53 null 0.04 0.28 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58176 526
FHH/EurMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 1.34 E-7mole 0.21 0.59 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55908 522
FHH/EurMcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 64 208.3 g 4.2 33.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58380 526
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 3.26 mmHg 3.49 9.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 16781 381
FHH/EurMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 50 1.38 E-7mole 0.11 0.79 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56553 522
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 33.17 % 5.61 13.73 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54981 522
FHH/EurMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 5 1.73 g/mg 0.16 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55013 522
FHH/EurMcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 159 0.12 mg/dl 0.0 0.06 standard blood chemistry panel 0 62174 527
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 0.09 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59911 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.46 mg/kg 0.78 2.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58852 526
FHH/EurMcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 25 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 62245 527
FHH/EurMcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 0.38 ml 0.01 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17434 381
FHH/EurMcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 7 1.54 g 0.06 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45831 461
FHH/EurMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 135.6 mmHg 6.76 21.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45843 461
FHH/EurMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 52.72 mmHg 4.61 20.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47963 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 0.18 IU/g 0.02 0.05 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47995 461
FHH/EurMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 48 101.69 mmHg 2.69 18.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44878 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 60.16 % 12.43 27.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45929 461
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 354.08 beats/min 23.41 74.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47677 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 47.58 % 5.31 16.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46953 461
FHH/EurMcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 47 post-ischemic value/pre-ischemic value x 100% 44.87 % 2.27 15.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47139 461
FHH/EurMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 114.32 mmHg 7.53 18.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45013 461
FHH/EurMcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 184.12 beats/min 23.58 52.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45078 461
FHH/EurMcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 150.73 % 36.24 95.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46036 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 6.32 ml/min/g 0.83 3.62 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46253 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 47 4.84 ml/min/g 0.16 1.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46264 461
FHH/EurMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 48 post-ischemic value/pre-ischemic value x 100% 63.61 % 2.61 18.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46128 461
FHH/EurMcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 43 223.63 beats/min 17.45 114.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45210 461
FHH/EurMcwi renal blood flow rate controlled in situ renal perfusion pressure (140 mmHg) Lopez B, et al., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22. renal blood flow trait male 140 days 12 7.95 ml/min/g 0.5 1.73 ultrasonic flowmeter 0.0 0 69369 1156
FHH/EurMcwi ratio of change in renal blood flow to change in renal perfusion pressure controlled in situ renal perfusion pressure (100-140 mmHg) Lopez B, et al., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22. renal blood flow trait male 140 days 12 0.8 null 0.08 0.28 ultrasonic flowmeter 0.0 0 69370 1156
FHH/EurMcwi blood urea nitrogen level control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. blood urea nitrogen amount male 189 days 7 20.5 mg/dl 3.22 8.52 automated blood analysis 0.0 0 ACE Autoanalyzer Clinical Chemistry System 96905 1738
FHH/EurMcwi serum total cholesterol level control condition Westbrook L, et al., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10. blood cholesterol amount male 168 days 6 102.0 mg/dl 9.7 23.76 serum total cholesterol measurement test 0.0 0 99505 2318
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 43.7 mmHg 3.55 7.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50652 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 138.48 mmHg 2.12 5.2 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50744 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 2.03 mmHg 7.31 14.61 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50811 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 2.05 mmHg 3.85 9.42 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50842 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 387.54 beats/min 13.35 26.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50888 481
FHH/EurMcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 145.47 % 5.44 16.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53845 381
FHH/EurMcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 146.83 % 6.2 19.6 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53864 381
FHH/EurMcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 142.17 % 5.53 18.33 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53867 381
FHH/EurMcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 109.53 % 2.79 19.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53886 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20186 381
FHH/EurMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 414.25 beats/min 11.44 37.95 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20924 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 5 38.51 mmHg 1.98 4.43 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19833 381
FHH/EurMcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 425.52 beats/min 6.37 14.25 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15589 381
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 -0.81 mmHg 2.41 6.83 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51085 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 -6.04 mmHg 3.13 4.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51130 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 -1.0 mmHg 2.75 7.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51135 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -27.08 beats/min 15.11 33.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51217 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 1.74 mEq/d 0.27 0.76 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51265 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 124.78 mmHg 3.22 7.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50949 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 36.57 mmHg 4.18 9.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50960 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 412.44 beats/min 11.88 29.1 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51385 481
FHH/EurMcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.66 degrees C 0.13 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19574 381
FHH/EurMcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypercapnia/control during standard conditions 250.3 % 25.98 73.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 19602 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 7.43 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14421 381
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -33.0 beats/min 25.62 72.46 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50348 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 7.53 mmHg 1.09 2.44 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50365 481
FHH/EurMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 10 37.35 mg/d 5.34 16.9 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51444 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.27 mg/dl 0.01 0.02 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51535 481
FHH/EurMcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.46 ml 0.05 0.18 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14623 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 9.52 mmHg 3.64 6.31 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14645 381
FHH/EurMcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 125.82 mmHg 3.56 10.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14667 381
FHH/EurMcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 384.44 beats/min 16.52 46.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14700 381
FHH/EurMcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 -0.45 degrees C 0.14 0.48 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14131 381
FHH/EurMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 90.37 breaths/min 4.39 13.89 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13656 381
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -41.3 beats/min 29.44 88.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50427 481
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.35 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18629 381
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.37 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14880 381
FHH/EurMcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 7 94.71 mg/dl 5.0 13.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36708 401
FHH/EurMcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 84.71 mg/dl 4.64 12.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36711 401
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 15 165.97 mmHg 7.47 28.91 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52534 482
FHH/EurMcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 11.17 ml/min/g 1.07 2.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46285 461
FHH/EurMcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 10.32 ml/min/g 0.4 1.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46289 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 7.84 ml/min/g 0.48 1.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46300 461
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 246.95 beats/min 8.85 21.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48155 461
FHH/EurMcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 157 202.85 U/l 3.75 47.04 standard blood chemistry panel 0 60442 527
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 20 0.47 IU/g 0.1 0.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47322 461
FHH/EurMcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 5.6 mmHg 0.51 1.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47376 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 58.21 % 7.35 12.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46371 461
FHH/EurMcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 5 1.94 g 0.15 0.34 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45384 461
FHH/EurMcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 40.86 mmHg 5.98 15.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45686 461
FHH/EurMcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 44 38.03 mmHg 2.76 18.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45332 461
FHH/EurMcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 40.6 mmHg 11.99 26.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45246 461
FHH/EurMcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 12.01 ml/min/g 0.67 2.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46704 461
FHH/EurMcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 158.4 mmHg 7.97 17.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45813 461
FHH/EurMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 874.58 s 108.64 325.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45875 461
FHH/EurMcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 55 160.0 g 4.7 35.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47846 461
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 328.76 beats/min 31.67 89.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47682 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 114.1 % 8.77 26.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44970 461
FHH/EurMcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.49 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16526 381
FHH/EurMcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 25 0.87 x 1000 cells/ul 0.13 0.64 automated blood cell counting method 0 60871 527
FHH/EurMcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 6.47 x 1000 cells/ul 0.82 2.17 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41486 401
FHH/EurMcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 56.0 % 0.88 2.34 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38355 401
FHH/EurMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.8 pg 0.09 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38385 401
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 7.04 IU/g 0.43 1.06 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49816 461
FHH/EurMcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 42.43 mmHg 3.78 10.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49797 461
FHH/EurMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 112 -7.0 null 0.03 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62861 528
FHH/EurMcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 60 140.1 g 5.5 42.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49551 461
FHH/EurMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 1.38 E-7mole 0.77 2.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54595 522
FHH/EurMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54688 522
FHH/EurMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 49 104.61 mmol/l 0.31 2.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40048 401
FHH/EurMcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 48 53.6 fl 0.14 0.95 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38689 401
FHH/EurMcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.19 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40384 401
FHH/EurMcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.48 x 1000 cells/ul 0.13 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40387 401
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 8 0.49 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58886 526
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 26.56 % 4.92 14.77 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54849 522
FHH/EurMcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 50 235.28 beats/min 4.68 33.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47644 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 66.8 % 5.74 15.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48504 461
FHH/EurMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 69.64 % 15.46 37.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48510 461
FHH/EurMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 49 3.79 g/dl 0.04 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40449 401
FHH/EurMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -7.15 null 0.15 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55020 522
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 37 19.01 IU/g 1.11 6.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48887 461
FHH/EurMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 55.8 % 7.41 16.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57296 522
FHH/EurMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 13 0.31 x 1000 cells/ul 0.03 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38919 401
FHH/EurMcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 7 5.27 g/dl 0.16 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42191 401
FHH/EurMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 47.23 % 0.99 2.62 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40685 401
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 11.82 ml/min/kg 0.95 2.68 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57568 526
FHH/EurMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 7 23.86 mmol/l 1.72 4.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42516 401
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 8 0.27 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 57725 526
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 53 20.85 ml/min/kg 1.06 7.71 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57863 526
FHH/EurMcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.04 degrees C 0.08 0.25 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 16328 381
FHH/EurMcwi both kidneys wet weight to body weight ratio control condition Westbrook L, et al., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10. kidney mass male 56 days 6 9.2 g/kg 0.27 0.66 post excision weight measurement 0.0 0 99457 2318
FHH/EurMcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 235.44 % 16.66 52.67 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14381 381
FHH/EurMcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 228.21 % 20.39 67.63 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14385 381
FHH/EurMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 86.5 breaths/min 3.07 9.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14441 381
FHH/EurMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 96.33 breaths/min 6.62 18.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14446 381
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 7 1.45 ml/min 0.13 0.33 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51798 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 8 1.77 ml/min 0.16 0.45 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51803 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 121.77 mmHg 0.93 2.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51829 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 4.01 ng/ml/h 1.09 2.43 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51843 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 9.85 beats/min 13.56 38.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51857 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51905 481
FHH/EurMcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 154.03 % 6.61 19.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53529 381
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -3.72 beats/min 14.86 33.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51703 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 7.64 beats/min 18.08 36.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50976 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 4.37 mmHg 1.82 5.15 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50995 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 0.45 mmHg 3.08 9.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51109 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 432.28 beats/min 13.8 41.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51122 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 32.17 mmHg 4.7 13.29 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51493 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 7.05 mmHg 1.68 4.12 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51496 481
FHH/EurMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 7 17.36 mg/d 2.63 6.96 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51554 481
FHH/EurMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 8 59.56 mg/d 16.55 46.8 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51558 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -18.2 beats/min 46.2 65.34 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50681 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 2 50.5 beats/min 43.3 61.24 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51308 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.25 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51309 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -27.23 beats/min 16.32 39.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51359 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 389.31 beats/min 12.58 28.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50877 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 2.88 mmHg 1.84 5.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50926 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -28.4 beats/min 24.13 59.1 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51406 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -10.16 beats/min 11.77 26.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51153 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -18.33 beats/min 13.72 33.61 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51164 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51173 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 12.46 mmHg 3.39 7.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51183 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 410.27 beats/min 18.86 46.2 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50446 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -24.77 beats/min 14.96 44.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50512 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.23 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51654 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 30.91 mmHg 4.23 11.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51665 481
FHH/EurMcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 36.75 degrees C 0.33 1.09 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13612 381
FHH/EurMcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 42 37.07 degrees C 0.1 0.66 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13623 381
FHH/EurMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 8 36.89 degrees C 0.22 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 17573 381
FHH/EurMcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 49 231.0 g 4.6 32.1 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17881 381
FHH/EurMcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 12 322.5 g 10.4 35.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17929 381
FHH/EurMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 11 37.7 degrees C 0.16 0.53 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17947 381
FHH/EurMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.49 degrees C 0.14 0.47 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17951 381
FHH/EurMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 37.46 degrees C 0.22 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17628 381
FHH/EurMcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.52 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17677 381
FHH/EurMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 419.87 beats/min 10.64 30.08 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17726 381
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.32 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18035 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20140 381
FHH/EurMcwi heart rate air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 420.82 beats/min 18.01 59.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17506 381
FHH/EurMcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 %change=VE during7-9 min hypercapnia/control during standard conditions 126.78 % 5.2 36.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18607 381
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.4 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18634 381
FHH/EurMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 11 37.53 degrees C 0.14 0.47 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19181 381
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 14 6.49 % 2.33 8.7 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49749 461
FHH/EurMcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 54.4 mmHg 9.24 20.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49821 461
FHH/EurMcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 48 978.1 s 33.1 229.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49361 461
FHH/EurMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 48 4.23 x 1000 cells/ul 0.16 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39927 401
FHH/EurMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 13 20.38 mmol/l 1.6 5.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43013 401
FHH/EurMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 166.0 mg/dl 8.39 23.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 40667 401
FHH/EurMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 102.5 mmol/l 0.38 1.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 40519 401
FHH/EurMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 102.29 mmol/l 0.42 1.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 40525 401
FHH/EurMcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 18 21.5 mg/dl 0.78 3.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40880 401
FHH/EurMcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 7 58.96 fl 0.34 0.91 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38168 401
FHH/EurMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 7.39 mg/dl 0.41 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38226 401
FHH/EurMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 13 85.38 mg/dl 1.6 5.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38456 401
FHH/EurMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 15.06 g/dl 0.34 0.9 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41628 401
FHH/EurMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 6 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62774 528
FHH/EurMcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 14 44.37 % 0.8 2.99 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57510 526
FHH/EurMcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 1096.9 s 77.69 205.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48927 461
FHH/EurMcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 79.21 ml/min 6.44 18.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 16238 381
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 14.99 mmHg 1.74 2.46 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16256 381
FHH/EurMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 99.8 % 0.2 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55376 522
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 10.38 ml/min/kg 0.62 2.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57650 526
FHH/EurMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 49 36.79 degrees C 0.11 0.78 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16876 381
FHH/EurMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 49 1.08 g/mg 0.06 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55821 522
FHH/EurMcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount male 70 days-84 days 159 5.56 g/dl 0.02 0.28 standard blood chemistry panel 0 61272 527
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 5 6.9 mmHg 3.81 8.53 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 16776 381
FHH/EurMcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait female 70 days-84 days 25 21.48 mmol/l 0.87 4.33 standard blood chemistry panel 0 61107 527
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.44 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15322 381
FHH/EurMcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 405.28 beats/min 8.17 23.12 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 15337 381
FHH/EurMcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 354.94 beats/min 7.82 20.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 15342 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 -0.03 null 0.02 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15349 381
FHH/EurMcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 144.25 breaths/min 8.62 27.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15372 381
FHH/EurMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 31.2 ml/min 2.63 8.72 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15172 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 -5.18 mmHg 8.26 18.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15186 381
FHH/EurMcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 318.89 beats/min 20.99 36.36 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15593 381
FHH/EurMcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 -0.34 degrees C 0.18 0.59 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15639 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 107.63 mmHg 5.23 12.82 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 15977 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 7.45 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14597 381
FHH/EurMcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.4 ml 0.02 0.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14619 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 3 121.93 mmHg 6.18 10.71 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14657 381
FHH/EurMcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 113.88 mmHg 7.4 22.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14662 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 108.53 mmHg 2.14 6.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15030 381
FHH/EurMcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 42 0.12 degrees C 0.06 0.39 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15733 381
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 18.64 mmHg 7.01 9.91 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15762 381
FHH/EurMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 438.2 beats/min 10.21 28.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15930 381
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 48 181.54 mmHg 2.9 20.07 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52552 482
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 48 183.29 mg/d 13.89 96.23 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52407 482
FHH/EurMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 48 431.04 beats/min 4.26 29.51 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52505 482
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 -1.7 mmHg 1.59 4.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50608 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 -3.9 mmHg 1.51 3.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50626 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 14 6.0 ng/ml/h 0.7 2.62 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52881 482
FHH/EurMcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 0.3 ml 0.01 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13987 381
FHH/EurMcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 152.9 % 17.25 51.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14037 381
FHH/EurMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 7.48 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17314 381
FHH/EurMcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 160.68 breaths/min 13.49 42.67 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13777 381
FHH/EurMcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 143.72 breaths/min 5.09 16.89 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13781 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 528.08 beats/min 5.36 15.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13784 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 440.03 beats/min 10.25 14.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13796 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 1 113.81 mmHg vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13901 381
FHH/EurMcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 244.4 % 13.57 40.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14087 381
FHH/EurMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 1 116.81 beats/min vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14102 381
FHH/EurMcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 5 124.62 mmHg 3.01 6.73 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14121 381
FHH/EurMcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 142.46 breaths/min 6.09 21.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17164 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 16 29.09 mmHg 0.6 2.4 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17261 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.43 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19728 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 3 -4.92 mmHg 2.72 4.71 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20015 381
FHH/EurMcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 57.86 ml/min 2.51 7.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20700 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20856 381
FHH/EurMcwi absolute change in blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18789 381
FHH/EurMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 31.89 g/dl 0.1 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 36315 401
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19018 381
FHH/EurMcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 18 5.37 g/dl 0.08 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37014 401
FHH/EurMcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 50 5.36 g/dl 0.07 0.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37025 401
FHH/EurMcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 7 11.71 mmol/l 1.11 2.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37046 401
FHH/EurMcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 18.9 pg 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37072 401
FHH/EurMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 13 5.65 g/dl 0.11 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37221 401
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 23.18 mmHg 0.81 2.29 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18821 381
FHH/EurMcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 114.91 breaths/min 5.08 19.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18318 381
FHH/EurMcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 37.21 ml/min 1.74 12.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20272 381
FHH/EurMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 45.77 ml/min 3.02 9.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18183 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 106.35 mmHg 1.98 3.95 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18245 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 -42.13 mmHg 3.04 9.6 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19466 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 124.63 mmHg 2.02 5.71 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19515 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 5 27.59 mmHg 1.91 4.27 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20416 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 570.99 beats/min 9.14 20.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20527 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 -0.02 null 0.01 0.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20566 381
FHH/EurMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 23.5 mg/dl 1.31 3.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42326 401
FHH/EurMcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 222.57 mg/dl 15.07 39.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39321 401
FHH/EurMcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 18.3 pg 0.11 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42597 401
FHH/EurMcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 51 142.63 mmol/l 0.47 3.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39451 401
FHH/EurMcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 17.99 g/dl 0.28 0.75 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39474 401
FHH/EurMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.99 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39523 401
FHH/EurMcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 118.99 % 5.87 18.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54551 381
FHH/EurMcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 141.48 % 6.82 21.56 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54573 381
FHH/EurMcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 111.46 % 4.4 14.59 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53575 381
FHH/EurMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 49 4.87 mmol/l 0.14 0.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43369 401
FHH/EurMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 13 0.14 x 1000 cells/ul 0.02 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40317 401
FHH/EurMcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.4 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Dyets 40381 401
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 23.71 ml/min/kg 1.63 3.65 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 58991 526
FHH/EurMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 8 0.81 g/kg 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 59021 526
FHH/EurMcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 112.07 % 7.16 22.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53732 381
FHH/EurMcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 4.95 x 1000 cells/ul 0.57 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41145 401
FHH/EurMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 15 1.19 g/kg 0.09 0.33 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59477 526
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59599 526
FHH/EurMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 35.02 ml/min/kg 3.19 8.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 59632 526
FHH/EurMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 13 1.85 g/dl 0.07 0.25 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41050 401
FHH/EurMcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 42.99 % 2.18 5.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47517 461
FHH/EurMcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 5 53.8 mmHg 9.11 20.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47566 461
FHH/EurMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 48 7.97 x 10E6 cells/ul 0.09 0.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42011 401
FHH/EurMcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 5 1151.06 s 61.18 136.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45389 461
FHH/EurMcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 39 post-ischemic value/pre-ischemic value x 100% 33.93 % 2.79 17.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48589 461
FHH/EurMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 50.75 mmHg 1.93 5.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48719 461
FHH/EurMcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 320.02 beats/min 37.3 91.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46516 461
FHH/EurMcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 7 36.43 degrees C 0.1 0.28 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 16333 381
FHH/EurMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 6 0.5 degrees C 0.3 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 16380 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 30.04 mmHg 0.46 1.3 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16453 381
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.37 null 0.11 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55705 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 54 -7.85 null 0.09 0.65 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56138 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 5 -7.56 null 0.12 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56176 522
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 11 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58541 526
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)