Strain Report - Rat Genome Database

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Pathways

Strain: LEW/NCrl

Symbol: LEW/NCrl
Strain: LEW
Substrain: NCrl
RGD ID: 61104
Citation ID: RRID:RGD_61104
Ontology ID: RS:0000520
Also Known As: LEW/NCrlBR
Type: inbred
Available Source: Charles River Laboratories USA
Origination: Charles River Laboratories USA
Description: Substrain of LEW obtained from Charles River, which was developed from Dr Margaret Lewis from Wistar stock in early 1950s. This came to Charles River from Tulane in 1970 at F34.
Coat Color: Albino
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
weight loss  (IAGP)

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. Deng AY, etal., J Clin Invest 1994 Jun;93(6):2701-9
2. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
3. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
4. PhysGen Strains PhysGen strains
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. Roman RJ, etal., Am J Physiol Renal Physiol. 2006 Jan 5;.

Region

Strain QTL Data
Symbol Name Trait
Bp30 Blood pressure QTL 30 arterial blood pressure trait   (VT:2000000)    
Bp38 Blood pressure QTL 38 arterial blood pressure trait   (VT:2000000)    
Bp7 Blood pressure QTL 7 arterial blood pressure trait   (VT:2000000)    
Bp8 Blood pressure QTL 8 arterial blood pressure trait   (VT:2000000)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 LEW/NCrl (ICL) View Damaging Variants
Rnor_5.0 LEW/NCrl (KNAW) View Damaging Variants
Rnor_6.0 LEW/NCrlBR (RGD) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease The blood pressure of females is 112 mmHg and of males is 104 mmHg. 629526
strain_other The average weight of females is 213g and of males 300g. 629526