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Strain Registration

Strain: BN.GK-(D1Wox18-D1Got254)/Ox

Symbol: BN.GK-(D1Wox18-D1Got254)/Ox
Strain: BN.GK-(D1Wox18-D1Got254)
Substrain: Ox
RGD ID: 1600339
Citation ID: RRID:RGD_1600339
Ontology ID: RS:0001197
Also Known As: BN.GK-Nidd/gk1; BN.GK-(D1Wox18-D1Got254); BN.GK-(D1Wox18-D1Got254)/Ox
Type: congenic
Available Source: Not Available
Origination: The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Description: This congenic strain is derived from GK rats which were from a colony in Paris (CNRS) obtained in 1995. BN rats were initially obtained from Charles River Laboratories, Margate, UK.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81103,780,943 - 267,096,252RGD_MAPPER_PIPELINE
mRatBN7.2194,644,435 - 257,091,168RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01100,133,276 - 278,978,026RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.01101,198,387 - 286,341,689RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4194,626,541 - 264,367,394RGD_MAPPER_PIPELINERGSC_v3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats. Collins SC, etal., Mamm Genome. 2006 Jun;17(6):538-47. Epub 2006 Jun 12.
2. Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Dumas ME, etal., Nat Genet. 2007 Apr 15;.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome. Wallis RH, etal., PLoS ONE. 2008 Aug 13;3(8):e2962.

Region

Position Markers

Flank 1 / 1 (D1Wox18)
Rat AssemblyChrPosition (strand)Source
GRCr81103,780,943 - 103,781,063 (+)Marker Load Pipeline
mRatBN7.2194,644,435 - 94,644,553 (+)MAPPER
Rnor_6.01100,133,276 - 100,133,395NCBI
Rnor_5.01101,198,387 - 101,198,506UniSTS
RGSC_v3.4194,626,541 - 94,626,661RGD
RGSC_v3.4194,626,542 - 94,626,661UniSTS
Celera188,911,307 - 88,911,426UniSTS
RGSC_v3.1194,704,652 - 94,704,772RGD
RH 3.4 Map1906.0UniSTS
RH 3.4 Map1906.0RGD
RH 2.0 Map1581.8RGD
Cytogenetic Map1q22UniSTS

Flank 2 / 1 (D1Got254)
Rat AssemblyChrPosition (strand)Source
GRCr81267,096,070 - 267,096,252 (+)Marker Load Pipeline
mRatBN7.21257,090,986 - 257,091,168 (+)MAPPER
Rnor_6.01278,977,845 - 278,978,026NCBI
Rnor_5.01286,341,508 - 286,341,689UniSTS
RGSC_v3.41264,367,212 - 264,367,394RGD
RGSC_v3.41264,367,213 - 264,367,394UniSTS
Celera1252,775,585 - 252,775,766UniSTS
RGSC_v3.11264,578,258 - 264,578,439RGD
RH 3.4 Map11679.3RGD
RH 3.4 Map11679.3UniSTS
RH 2.0 Map11304.4RGD
Cytogenetic Map1q55UniSTS
Strain QTL Data
Symbol Name Trait
Niddm68 Non-insulin dependent diabetes mellitus QTL 68 blood glucose amount   (VT:0000188)    
Niddm70 Non-insulin dependent diabetes mellitus QTL 70 blood insulin amount   (VT:0001560)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics at 24 weeks all animals exhibited glucose intolerance but only males had enhanced insulin secretion 1598974
strain_other this congenic was used to determine 158 metabotypic QTLs using 1 H NMR 1601533
strain_other Blood pressure is not altered by the GK allele. 2300263