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Strain Registration

Strain: SDR/Slc

Symbol: SDR/Slc
Strain: SDR
Substrain: Slc
Full Name: Spontaneous dwarf rat
RGD ID: 1302698
Citation ID: RRID:RRRC_00066
Ontology ID: RS:0000708
Alleles: Gh1sdr
Variant(s): Gh1sdrv-var1
Also Known As: NBRP Rat No: 0151
Type: inbred
Available Source: National BioResource Project for the Rat in Japan, Rat Resource and Research Center
Origination: Japan SLC, Inc
Description: The G to A substitution at the end of the 3rd intron of the rat Growth hormone gene was identified as the cause of the dwarf phenotype. This spontaneous mutation affected the 3' splice/acceptor site. Judging from this point mutation, one would predict an abnormal splicing and a 1-base deletion in the GH mRNA. Strain is from Japan SLC, Inc., Shizuoka, Japan.
Coat Color: Albino
Inbred Generations: F10
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-05-04)
Research Usage Metabolism





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. IGF-I and IGF-binding protein gene expressions in spontaneous dwarf rat. Nogami H, etal., Am J Physiol. 1994 Sep;267(3 Pt 1):E396-401.
2. Studies on prolactin and growth hormone gene expression in the pituitary gland of spontaneous dwarf rats. Nogami H, etal., Endocrinology. 1989 Aug;125(2):964-70.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Molecular mechanism of growth hormone (GH) deficiency in the spontaneous dwarf rat: detection of abnormal splicing of GH messenger ribonucleic acid by the polymerase chain reaction. Takeuchi T, etal., Endocrinology. 1990 Jan;126(1):31-8.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Gh1sdrv-var1 chr10 91228776 91228776 C T point_mutation mRatBN7.2
Gh1sdrv-var1 chr10 94486878 94486878 C T point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem No immunoreactive GH cells were detected by immunocytochemistry in the pituitary gland. 1578505

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-09 SDR/Slc  Spontaneous dwarf rat  SDR/Slc  Spontaneous dwarf rat  Name updated 68913 APPROVED
2012-04-18 SDR/Slc  Spontaneous dwarf rat  SDR/Slc  Spontaneous dwarf rat  Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00066 RGD