Gh1<sup>sdr</sup> (null) - Rat Genome Database

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Gene: Gh1sdr (null) Rattus norvegicus
Symbol: Gh1sdr
RGD ID: 12880380
Description: The G to A substitution at the end of the 3rd intron of the rat Growth hormone gene was identified as the cause of the dwarf phenotype in SDR rats. This spontaneous mutation affected the 3' splice/acceptor site causing 1-bp deletion in mRNA and resulting in pre-mature termination of translation.
ASSOCIATED WITH decreased growth hormone level; decreased prolactin level; ASSOCIATED WITH Dwarfism; isolated growth hormone deficiency
Type: allele  of Gh1  
Also known as: Gh1sdr
Is Marker For: Strains:   SDR/Slc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
1. Nogami H, etal., Endocrinology. 1989 Aug;125(2):964-70.
2. Takeuchi T, etal., Endocrinology. 1990 Jan;126(1):31-8.


Related Rat Strains
The following Strains have been annotated to Gh1sdr



Nucleotide Sequences

Rat Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type
Gh1sdrv-var1 chr10 94486878 94486878 C T point_mutation

Additional Information