Ston1 (stonin 1) - Rat Genome Database

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Pathways
Gene: Ston1 (stonin 1) Rattus norvegicus
Analyze
Symbol: Ston1
Name: stonin 1
RGD ID: 727878
Description: Predicted to enable clathrin adaptor activity. Predicted to be involved in clathrin-dependent endocytosis; regulation of endocytosis; and synaptic vesicle endocytosis. Predicted to act upstream of or within several processes, including cell-substrate junction organization; platelet-derived growth factor receptor signaling pathway; and ruffle assembly. Predicted to be located in cell leading edge; cell projection; and clathrin-coated pit. Predicted to be part of AP-2 adaptor complex. Predicted to be active in synaptic vesicle. Orthologous to several human genes including STON1 (stonin 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Salf; Sblf; stoned B-like factor; stoned B/TFIIA-alpha/beta-like factor; stonin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8611,596,726 - 11,646,098 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl611,572,905 - 11,615,635 (-)EnsemblGRCr8
mRatBN7.265,843,186 - 5,892,557 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,843,185 - 5,892,449 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx66,126,910 - 6,143,871 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.066,436,295 - 6,453,257 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.065,963,459 - 5,980,420 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,332,465 - 12,379,783 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,362,813 - 12,379,783 (+)Ensemblrn6Rnor6.0
Rnor_5.0622,295,409 - 22,342,414 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4612,473,166 - 12,490,453 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera65,617,926 - 5,634,858 (-)NCBICelera
RGSC_v3.1612,482,954 - 12,490,453 (+)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. Martina JA, etal., J Cell Biol 2001 May 28;153(5):1111-20.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11454741   PMID:15632090   PMID:26437238  


Genomics

Comparative Map Data
Ston1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8611,596,726 - 11,646,098 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl611,572,905 - 11,615,635 (-)EnsemblGRCr8
mRatBN7.265,843,186 - 5,892,557 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,843,185 - 5,892,449 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx66,126,910 - 6,143,871 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.066,436,295 - 6,453,257 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.065,963,459 - 5,980,420 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,332,465 - 12,379,783 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,362,813 - 12,379,783 (+)Ensemblrn6Rnor6.0
Rnor_5.0622,295,409 - 22,342,414 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4612,473,166 - 12,490,453 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera65,617,926 - 5,634,858 (-)NCBICelera
RGSC_v3.1612,482,954 - 12,490,453 (+)NCBI
Cytogenetic Map6q12NCBI
STON1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38248,530,154 - 48,598,513 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl248,529,376 - 48,598,922 (+)Ensemblhg38GRCh38
GRCh37248,757,293 - 48,825,652 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36248,661,267 - 48,679,549 (+)NCBIBuild 36Build 36hg18NCBI36
Celera248,647,657 - 48,665,958 (+)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef248,493,878 - 48,559,017 (+)NCBIHuRef
CHM1_1248,687,388 - 48,756,387 (+)NCBICHM1_1
T2T-CHM13v2.0248,536,051 - 48,601,303 (+)NCBIT2T-CHM13v2.0
Ston1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391788,905,043 - 88,955,293 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1788,905,112 - 88,970,014 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381788,597,615 - 88,647,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1788,597,684 - 88,662,586 (+)Ensemblmm10GRCm38
MGSCv371789,025,895 - 89,045,064 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361786,941,942 - 86,952,124 (+)NCBIMGSCv36mm8
Celera1793,037,396 - 93,056,634 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1758.1NCBI
Ston1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544115,112,555 - 15,127,354 (+)Ensembl
ChiLan1.0NW_00495544115,071,765 - 15,126,534 (+)NCBIChiLan1.0ChiLan1.0
STON1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21277,782,281 - 77,847,876 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A77,786,249 - 77,851,686 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A48,656,425 - 48,722,288 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A49,577,511 - 49,642,326 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A49,577,562 - 49,721,845 (+)EnsemblpanPan2panpan1.1
STON1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11050,421,635 - 50,470,302 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1050,436,715 - 50,467,878 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1050,308,598 - 50,320,873 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01051,300,762 - 51,349,431 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1051,300,563 - 51,349,344 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11051,034,108 - 51,046,363 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01051,321,258 - 51,333,576 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01051,509,291 - 51,521,570 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ston1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629232,637,354 - 32,687,611 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,065,711 - 4,116,652 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,068,102 - 4,116,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STON1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl392,092,635 - 92,109,713 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1392,091,763 - 92,145,386 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2397,836,597 - 97,851,449 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ston1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473829,785,501 - 29,803,752 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473829,747,179 - 29,803,676 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ston1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v174,156,514 - 4,240,681 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ston1
410 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:106
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000022370
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 74 59 6 338 174 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022370   ⟹   ENSRNOP00000022370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl611,572,905 - 11,615,635 (-)Ensembl
mRatBN7.2 Ensembl65,843,187 - 5,862,131 (-)Ensembl
Rnor_6.0 Ensembl612,362,813 - 12,379,783 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118638   ⟹   ENSRNOP00000088331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl611,598,700 - 11,615,635 (-)Ensembl
mRatBN7.2 Ensembl65,843,185 - 5,892,449 (-)Ensembl
RefSeq Acc Id: NM_182954   ⟹   NP_891999
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,598,700 - 11,615,635 (-)NCBI
mRatBN7.265,845,160 - 5,862,097 (-)NCBI
Rnor_6.0612,362,813 - 12,379,783 (+)NCBI
Rnor_5.0622,295,409 - 22,342,414 (+)NCBI
RGSC_v3.4612,473,166 - 12,490,453 (+)RGD
Celera65,617,926 - 5,634,858 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239743   ⟹   XP_006239805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,596,726 - 11,646,098 (-)NCBI
mRatBN7.265,843,186 - 5,892,557 (-)NCBI
Rnor_6.0612,332,465 - 12,379,670 (+)NCBI
Rnor_5.0622,295,409 - 22,342,414 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239744   ⟹   XP_006239806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,596,726 - 11,614,085 (-)NCBI
mRatBN7.265,843,186 - 5,859,569 (-)NCBI
Rnor_6.0612,364,476 - 12,379,670 (+)NCBI
Rnor_5.0622,295,409 - 22,342,414 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764481   ⟹   XP_008762703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,596,726 - 11,615,669 (-)NCBI
mRatBN7.265,843,186 - 5,862,131 (-)NCBI
Rnor_6.0612,362,271 - 12,379,670 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112436   ⟹   XP_038968364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,596,726 - 11,615,669 (-)NCBI
mRatBN7.265,843,186 - 5,862,131 (-)NCBI
RefSeq Acc Id: XM_063262036   ⟹   XP_063118106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,596,726 - 11,615,669 (-)NCBI
RefSeq Acc Id: NP_891999   ⟸   NM_182954
- UniProtKB: A6H9B6 (UniProtKB/TrEMBL),   Q7TNJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239805   ⟸   XM_006239743
- Peptide Label: isoform X1
- UniProtKB: A6H9B6 (UniProtKB/TrEMBL),   Q7TNJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239806   ⟸   XM_006239744
- Peptide Label: isoform X1
- UniProtKB: A6H9B6 (UniProtKB/TrEMBL),   Q7TNJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762703   ⟸   XM_008764481
- Peptide Label: isoform X1
- UniProtKB: A6H9B6 (UniProtKB/TrEMBL),   Q7TNJ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022370   ⟸   ENSRNOT00000022370
RefSeq Acc Id: XP_038968364   ⟸   XM_039112436
- Peptide Label: isoform X2
- UniProtKB: F1MAC6 (UniProtKB/TrEMBL),   Q7TNJ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088331   ⟸   ENSRNOT00000118638
RefSeq Acc Id: XP_063118106   ⟸   XM_063262036
- Peptide Label: isoform X1
- UniProtKB: A6H9B6 (UniProtKB/TrEMBL),   Q7TNJ9 (UniProtKB/TrEMBL)
Protein Domains
MHD   SHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAC6-F1-model_v2 AlphaFold F1MAC6 1-731 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694401
Promoter ID:EPDNEW_R4925
Type:initiation region
Name:Ston1_1
Description:stonin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0612,362,829 - 12,362,889EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727878 AgrOrtholog
BioCyc Gene G2FUF-38773 BioCyc
Ensembl Genes ENSRNOG00000016688 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022370.8 UniProtKB/TrEMBL
  ENSRNOT00000118638 ENTREZGENE
  ENSRNOT00000118638.2 UniProtKB/TrEMBL
Gene3D-CATH Mu homology domain, subdomain B UniProtKB/TrEMBL
InterPro Adaptor_comp_med_subunit UniProtKB/TrEMBL
  AP2_Mu_C_sf UniProtKB/TrEMBL
  MHD UniProtKB/TrEMBL
  SHD UniProtKB/TrEMBL
  Stonin UniProtKB/TrEMBL
KEGG Report rno:360202 UniProtKB/TrEMBL
NCBI Gene 360202 ENTREZGENE
PANTHER AP COMPLEX SUBUNIT MU UniProtKB/TrEMBL
Pfam Adap_comp_sub UniProtKB/TrEMBL
PhenoGen Ston1 PhenoGen
PIRSF Stonin UniProtKB/TrEMBL
PROSITE MHD UniProtKB/TrEMBL
  SHD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016688 RatGTEx
Superfamily-SCOP AP50 UniProtKB/TrEMBL
UniProt A0A8I6A974_RAT UniProtKB/TrEMBL
  A6H9B6 ENTREZGENE, UniProtKB/TrEMBL
  F1MAC6 ENTREZGENE, UniProtKB/TrEMBL
  Q7TNJ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-03-08 Ston1  stonin 1  Sblf  stoned B-like factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Sblf  stoned B-like factor      Symbol and Name status set to approved 1299863 APPROVED