RGD Reference Report - Jagged2: a serrate-like gene expressed during rat embryogenesis. - Rat Genome Database

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Jagged2: a serrate-like gene expressed during rat embryogenesis.

Authors: Shawber, C  Boulter, J  Lindsell, CE  Weinmaster, G 
Citation: Shawber C, etal., Dev Biol 1996 Nov 25;180(1):370-6.
RGD ID: 69864
Pubmed: PMID:8948600   (View Abstract at PubMed)
DOI: DOI:10.1006/dbio.1996.0310   (Journal Full-text)

DSL (Delta, Serrate, Lag-2) ligands activate Notch signaling and thereby regulate the differentiation of many different cell types during development. We have isolated a novel Serrate-like gene, Jagged2, whose amino acid sequence and expression pattern during rat embryogenesis suggest that it functions as a ligand for Notch. In contrast to previously described DSL ligands for Notch, Jagged2 is not widely expressed in the developing central nervous system. However, Jagged2 and Notch1 are coexpressed in the apical ectodermal ridge (AER), suggesting a role for this ligand-receptor pair in limb development. Furthermore, unlike Jagged1, Jagged2 is coexpressed with Notch in the developing thymus, where it may induce Notch signaling to direct T-cell fate. Our data are consistent with the idea that the diversity of cell types regulated by Notch signaling is a consequence of activation of unique Notch isoforms by different DSL ligands.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Jag2Ratcell fate determination involved_inNAS PMID:8948600UniProt 
Jag2Ratembryonic limb morphogenesis involved_inNAS PMID:8948600UniProt 
Jag2RatNotch signaling pathway involved_inNAS PMID:8948600UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Jag2RatNotch binding enablesNAS PMID:8948600UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Jag2  (jagged canonical Notch ligand 2)

Objects referenced in this article
Gene JAG2 jagged canonical Notch ligand 2 Homo sapiens

Additional Information